1H-Pyrrolo[2,3-b]pyridine-2-carboxaldehyde (9CI)
Application- Product Name
- 1H-Pyrrolo[2,3-b]pyridine-2-carboxaldehyde (9CI)
- CAS No.
- 394223-03-1
- Chemical Name
- 1H-Pyrrolo[2,3-b]pyridine-2-carboxaldehyde (9CI)
- Synonyms
- 7-Azaindole-2-carbaldehyde;3-b]pyridine-2-carbaldehyde;7-azaindole-2-carboxaldehyde;7-Azazindole-2-carboxyaldehyde;1H-Pyrrolo[2,3-b]pyridin-2-carbaldehyd;1H-Pyrrolo[2,3-b]pyridine-2-carboxaldehyde;1H-Pyrrolo[2,3-b]pyridine-2-carboxaldehyde (9CI)
- CBNumber
- CB21089884
- Molecular Formula
- C8H6N2O
- Formula Weight
- 146.15
- MOL File
- 394223-03-1.mol
1H-Pyrrolo[2,3-b]pyridine-2-carboxaldehyde (9CI) Property
- Density
- 1.368±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 11.93±0.40(Predicted)
- Appearance
- White to yellow Solid
- InChI
- InChI=1S/C8H6N2O/c11-5-7-4-6-2-1-3-9-8(6)10-7/h1-5H,(H,9,10)
- InChIKey
- ATTNRYFIYJHUOG-UHFFFAOYSA-N
- SMILES
- C12NC(C=O)=CC1=CC=CN=2
- CAS DataBase Reference
- 394223-03-1
Safety
- HS Code
- 2933998090
N-Bromosuccinimide Price
- Product number
- B530398
- Product name
- 1H-pyrrolo[2,3-b]pyridine-2-carbaldehyde
- Packaging
- 50mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- P13109
- Product name
- 7-Azaindole-2-carboxyaldehyde
- Purity
- 95%
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- Y8980
- Product name
- 1H-Pyrrolo[2,3-b]pyridine-2-carbaldehyde
- Packaging
- 250mg
- Price
- $131
- Updated
- 2021/12/16
- Product number
- OR929606
- Product name
- 1H-Pyrrolo[2,3-b]pyridine-2-carbaldehyde
- Purity
- 95%
- Packaging
- 250mg
- Price
- $205
- Updated
- 2021/12/16
- Product number
- 4H56-1-829
- Product name
- 1H-Pyrrolo[2,3-b]pyridine-2-carbaldehyde
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $290
- Updated
- 2021/12/16
1H-Pyrrolo[2,3-b]pyridine-2-carboxaldehyde (9CI) Chemical Properties,Usage,Production
Application
1H-pyrrolo[2,3-B]pyridine-2-carboxaldehyde is an important organic synthesis intermediate. Its aldehyde unit at position 2 exhibits high chemical reactivity and can be used for the structural modification and synthesis of various organic functional molecules. It has broad application potential in drug synthesis, biomedical research, and organic chemistry research.
Synthesis
221675-35-0
394223-03-1
Step c: Synthesis of 1H-pyrrolo[2,3-b]pyridine-2-carboxaldehyde [0452] A solution of ethyl 1H-pyrrolo[2,3-b]pyridine-2-carboxylate (190 mg, 1.0 mmol) in THF (5.0 mL) was slowly added dropwise at -20 °C to a suspension of LiAlH4 (42 mg, 1.1 mmol) in THF (10.0 mL) in a suspension of LiAlH4 (42 mg, 1.1 mmol). The reaction mixture was stirred continuously at -20 °C for 2 hours. Upon completion of the reaction, the reaction was quenched with saturated NH4Cl solution (10.0 mL). The reaction mixture was filtered and the filter cake was washed with ethyl acetate. The combined filtrates were sequentially washed with brine, dried over anhydrous Na2SO4 and then concentrated to afford 120 mg of 1H-pyrrolo[2,3-b]pyridine-2-carbaldehyde in 67% yield. The resulting product was used directly in the next reaction without further purification.
References
[1] Patent: WO2012/178015, 2012, A2. Location in patent: Page/Page column 113
1H-Pyrrolo[2,3-b]pyridine-2-carboxaldehyde (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1H-Pyrrolo[2,3-b]pyridine-2-carboxaldehyde (9CI) manufacturers
- Product
- 1H-Pyrrolo[2,3-b]pyridine-2-carboxaldehyde (9CI) 394223-03-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-12-18