3-(METHYLSULFONYL)BENZENESULFONYLCHLORIDE
- Product Name
- 3-(METHYLSULFONYL)BENZENESULFONYLCHLORIDE
- CAS No.
- 5335-40-0
- Chemical Name
- 3-(METHYLSULFONYL)BENZENESULFONYLCHLORIDE
- Synonyms
- 3-mesylbenzenesulfonyl chloride;3-Methanesulfonylbenzenesulfonyl chloride;3-(Chlorosulphonyl)phenyl methyl sulphone;Benzenesulfonyl chloride, 3-(methylsulfonyl)-;3-(Methylsulfonyl)benzene-1-sulfonyl chloride
- CBNumber
- CB21096497
- Molecular Formula
- C7H7ClO4S2
- Formula Weight
- 254.71
- MOL File
- 5335-40-0.mol
3-(METHYLSULFONYL)BENZENESULFONYLCHLORIDE Property
- Melting point:
- 93～96℃
- Boiling point:
- 449.7±37.0 °C(Predicted)
- Density
- 1.517±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- crystalline solid
- color
- White to off white
- CAS DataBase Reference
- 5335-40-0
Safety
- RIDADR
- UN3261
- HazardClass
- 8
- HS Code
- 2904990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H290May be corrosive to metals
H301Toxic if swalloed
H314Causes severe skin burns and eye damage
H330Fatal if inhaled
- Precautionary statements
-
P234Keep only in original container.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P284Wear respiratory protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P363Wash contaminated clothing before reuse.
P390Absorb spillage to prevent material damage.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P406Store in corrosive resistant/… container with a resistant inner liner.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M339215
- Product name
- 3-(Methylsulfonyl)benzenesulfonylChloride
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- M339215
- Product name
- 3-(Methylsulfonyl)benzenesulfonylChloride
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- M339215
- Product name
- 3-(Methylsulfonyl)benzenesulfonylChloride
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- OR7993
- Product name
- 3-(Methylsulphonyl)benzenesulphonylchloride
- Purity
- 95%
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
- Product number
- 6663-5-X9
- Product name
- 3-(Methylsulfonyl)benzenesulfonyl chloride
- Packaging
- 1g
- Price
- $21
- Updated
- 2021/12/16
3-(METHYLSULFONYL)BENZENESULFONYLCHLORIDE Chemical Properties,Usage,Production
Synthesis
3112-85-4
5335-40-0
The general procedure for the synthesis of 3-methylsulfonylbenzenesulfonyl chloride from phenylmethylsulfone was as follows: the intermediate 3-methylsulfonylbenzene-1-sulfonyl chloride was synthesized with reference to the method reported by Park et al. in J. Med. Chem. 2007, 51(21):6902-6915. The operation was as follows: methylsulfonylbenzene (110 g, 0.7 mol) was mixed with chlorosulfonic acid (450 mL, 6.7 mol), and the reaction was heated at 90 °C for 18 hours. Upon completion of the reaction, the reaction mixture was cooled to about 21 °C and subsequently slowly poured onto crushed ice. The resulting slurry was extracted twice with EtOAc (2 L each). The organic phases were combined, washed with brine (50 mL) and subsequently dried over sodium sulfate, filtered and concentrated under reduced pressure to give the intermediate sulfonyl chloride (125 g, 75% yield) as an off-white solid. The product was characterized by 1H NMR (400 MHz, CDCl3) with the following chemical shifts: δ 8.61 (1H, t, J = 1.7 Hz), 8.35-8.31 (2H, m), 7.90 (1H, t, J = 7.9 Hz), 3.15 (3H, s).
References
[1] Patent: US2014/206769, 2014, A1. Location in patent: Paragraph 0146
[2] Patent: EP3348548, 2018, A1. Location in patent: Paragraph 0103
3-(METHYLSULFONYL)BENZENESULFONYLCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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