(Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid

Product Name: (Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid
CAS No.: 80544-17-8
Chemical Name: (Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid
Synonyms: NICA;MICAAcid;Cefixime Impurity 9;Mannitol Impurity 65;Cefixime Impurity 39;Cefixime side chain acid;Cefoxime side chain acid;(Z)-(2-Aminothiazol-4-yl)-;Cefacoxime side chain acid;Cefixime side chain acid( TBKWCLS)
CBNumber: CB2110046
Molecular Formula: C8H9N3O5S
Formula Weight: 259.24
MOL File: 80544-17-8.mol

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(Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid Property

Melting point:: >160°C (dec.)
Boiling point:: 481.1±51.0 °C(Predicted)
Density: 1?+-.0.1 g/cm3(Predicted)
storage temp.: Refrigerator, under inert atmosphere
solubility: DMSO (Slightly), Methanol (Slightly, Heated)
pka: 2.40±0.10(Predicted)
form: Solid
color: White to Off-White
InChI: InChI=1S/C8H9N3O5S/c1-15-5(12)2-16-11-6(7(13)14)4-3-17-8(9)10-4/h3H,2H2,1H3,(H2,9,10)(H,13,14)/b11-6-
InChIKey: AGFYEFQBXHONNW-WDZFZDKYSA-N
SMILES: C(O)(=O)/C(/C1=CSC(N)=N1)=N\OCC(OC)=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A633340
Product name: (Z)-2-(2-Aminothiazol-4-yl)-2-((2-methoxy-2-oxoethoxy)imino)aceticAcid
Packaging: 5g
Price: $75
Updated: 2021/12/16

Oakwood

Product number: 036575
Product name: (Z)-(2-Aminothiazol-4-yl)methoxycarbonylmethoxyiminoaceticacid
Purity: 99%
Packaging: 1g
Price: $12
Updated: 2021/12/16

Oakwood

Product number: 036575
Product name: (Z)-(2-Aminothiazol-4-yl)methoxycarbonylmethoxyiminoaceticacid
Purity: 99%
Packaging: 5g
Price: $25
Updated: 2021/12/16

Oakwood

Product number: 036575
Product name: (Z)-(2-Aminothiazol-4-yl)methoxycarbonylmethoxyiminoaceticacid
Purity: 99%
Packaging: 25g
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: J11545
Product name: CefiximeImpurity1
Packaging: 100mg
Price: $98
Updated: 2021/12/16

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(Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid Chemical Properties,Usage,Production

Uses

(Z)-2-(2-amino-4-thiazolyl)-2-methoxycarbonylmethoxyiminoacetic acid (cefixime side chain acid) is an important side chain for the synthesis of the third and fourth generation cephalosporins It is of great economic and practical value to strengthen its research and development.

Uses

(Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid can be used as an intermediate in organic synthesis.

Preparation

The synthesis of cefixime side chain acid takes tert-butyl acetoacetate as raw material, through the steps of oximation, etherification, chlorination, cyclization and hydrolysis, to synthesize (Z)-2-(2-amino Thiazol-4-yl)-2-methoxycarbonylmethoxyiminoacetic acid.

(Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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(Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid Suppliers

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View Lastest Price from (Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: (Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid 80544-17-8
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%+
Supply Ability: 300 MT
Release date: 2020-05-23

Career Henan Chemical Co

Product: (Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid 80544-17-8
Price: US $7.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-21

80544-17-8, (Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acidRelated Search:

Ethyl 2-(Chlorosulfonyl)acetate Glycine Ethyl acetate Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) (Z)-2-(TERT-METHOXYCARBONYLMETHOXYIMINO)-2-(2-AMINOTHIAZOL-4-YL)ACETIC ACID Chloroacetic acid Acetic anhydride Cefixime 4-THIAZOLEACETIC ACID, 2-AMINO-ALPHA-[[2-(1,1-DIMETHYLETHOXY)-2-OXOETHOXY]IMINO]-, ANHYDRIDE WITH DIETHYL HYDROGEN PHOSPHATE, (Z)- (Z)-2-(2-Aminothiazol-4-yl)-2-(tert-butoxycarbonylmethoxyimino)acetic acid Diethyl thiophosphoryl-(Z)-2-(2-aminothiazol-4-yl)-2-(tert-butoxycarbonyl)isopropoxyiminoacetate (Z)-2-(tert-Butoxycarbonylprop-2-oxyimino)-2-(2-tritylaminothiazol-4-yl)acetic acid Ethyl 2-(2-aminothiazole-4-yl)-2-(1-tert-butoxycarbonyl-1-methylethoxyimino)acetate 4-THIAZOLEACETIC ACID, 2-AMINO-ALPHA-[[2-(1,1-DIMETHYLETHOXY)-1,1-DIMETHYL-2-OXOETHOXY]IMINO]-, ANHYDRIDE WITH DIETHYL HYDROGEN PHOSPHATE, (Z)- POLY(METHYL METHACRYLATE) ISOTACTIC 4-THIAZOLEACETIC ACID, 2-AMINO-ALPHA-[[2-(1,1-DIMETHYLETHOXY)-2-OXOETHOXY]IMINO]-, ANHYDRIDE WITH O,O-DIETHYL HYDROGEN PHOSPHOROTHIOATE (Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid (Z)-(METHOXYCARBONYLMETHOXYIMINO)-2-(2-AMINOTHIAZOL-4-YL)ACETIC ACID

NICA

(Z)-2-Amino-ALPHA-[(2-methoxy-2-oxoethoxy)-imino]-4-thiazoleacetic acid

MICAAcid

(Z)-2-(2-AMINOTHIAZOL-4-YL)-2-METHOXYCARBONYLMETHOXYIMINOACETIC ACID

(Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid

(Z)-2-(2-METHOXY-2-OXOETHOXYIMINO)-2-(2-METHYLTHIAZOL-4-YL)ACETIC ACID

(Z)-(2-Aminothiazol-4-yl)-

(Z)-2-(2-AMinothiazol-4-yl)-2-((2-Methoxy-2-oxoethoxy)iMino)acetic acid

Cefixime side chain acid

Cefixime Impurity 9

(2-AMINOTHIAZOL-4-YL)-METHOXYCARBONYLMETHOXYIMINOACETIC ACID

(2Z)-2-(2-amino-4-thiazolyl)-2-(2-methoxy-2-oxoethoxy)iminoacetic acid

(Z)-2-(t-MethoxycarbonylMethoxyimino)-2-(2-Aminothiazol-4-yl)Acetic Acid

4-Thiazoleacetic acid, 2-amino-α-[(2-methoxy-2-oxoethoxy)imino]-, (αZ)-

(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(2-methoxy-2-oxoethoxy)iminoacetic acid

(Z)-2-(tert-Methoxycarbonyl Methoxyimino)-2-(2-Aminothiazol-...

Cefoxime side chain acid

Cefacoxime side chain acid

Cefixime side chain acid( TBKWCLS)

Mannitol Impurity 65

Cefixime Impurity 39

(Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic

(Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid - [M92223]

80544-17-8