2-Bromo-5-fluoropyrimidine
- Product Name
- 2-Bromo-5-fluoropyrimidine
- CAS No.
- 947533-45-1
- Chemical Name
- 2-Bromo-5-fluoropyrimidine
- Synonyms
- 2-Bromo-5-fluoropyrimidine;2-Bromo-5-fluoro-1,3-diazine;PyriMidine, 2-broMo-5-fluoro-;2-Bromo-5-fluoropyrimidine ISO 9001：2015 REACH
- CBNumber
- CB21113143
- Molecular Formula
- C4H2BrFN2
- Formula Weight
- 176.97
- MOL File
- 947533-45-1.mol
2-Bromo-5-fluoropyrimidine Property
- Boiling point:
- 255.0±32.0 °C(Predicted)
- Density
- 1.838±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- crystals
- pka
- -2.67±0.22(Predicted)
- color
- Light brown/brown
- InChI
- InChI=1S/C4H2BrFN2/c5-4-7-1-3(6)2-8-4/h1-2H
- InChIKey
- ANSMRNCOBLTNBO-UHFFFAOYSA-N
- SMILES
- C1(Br)=NC=C(F)C=N1
- CAS DataBase Reference
- 947533-45-1
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B693403
- Product name
- 2-Bromo-5-fluoropyrimidine
- Packaging
- 1g
- Price
- $275
- Updated
- 2021/12/16
- Product number
- CAPOB11618
- Product name
- 2-Bromo-5-fluoropyrimidine
- Purity
- 95%
- Packaging
- 5g
- Price
- $300
- Updated
- 2021/12/16
- Product number
- B11618
- Product name
- 2-Bromo-5-fluoropyrimidine
- Purity
- 95%
- Packaging
- 5g
- Price
- $300
- Updated
- 2021/12/16
- Product number
- FB57428
- Product name
- 2-Bromo-5-fluoropyrimidine
- Packaging
- 2g
- Price
- $390
- Updated
- 2021/12/16
- Product number
- J55162
- Product name
- 2-Bromo-5-fluoropyrimidine
- Packaging
- 10g
- Price
- $420
- Updated
- 2021/12/16
2-Bromo-5-fluoropyrimidine Chemical Properties,Usage,Production
Synthesis
62802-42-0
947533-45-1
Step A: 2-chloro-5-fluoropyrimidine (2 mL, 22.18 mmol) was dissolved in propionitrile (20 mL) and bromotrimethylsilane (6 mL) was added. The reaction mixture was transferred to a sealed vial and heated at 150 °C for 1 hour. Upon completion of the reaction, the mixture was allowed to cool to room temperature and subsequently concentrated under reduced pressure. The concentrated residue was partitioned between ethyl acetate (EtOAc) and saturated aqueous sodium bicarbonate (NaHCO3). The organic phase was separated, dried over anhydrous sodium sulfate and concentrated again under reduced pressure. The resulting residue was dissolved in hexane and cooled overnight at -30 °C to precipitate a solid. The solid was collected by filtration to afford the target product 2-bromo-5-fluoropyrimidine (2.03 g, 51% yield). The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3): δ 8.49 (s, 2H).
References
[1] Patent: US2012/53174, 2012, A1. Location in patent: Page/Page column 44
2-Bromo-5-fluoropyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Bromo-5-fluoropyrimidine manufacturers
- Product
- 2-Bromo-5-fluoropyrimidine 947533-45-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-01
- Product
- 2-Bromo-5-fluoropyrimidine 947533-45-1
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- 100kg
- Release date
- 2018-12-24