ChemicalBook > CAS DataBase List > 3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE

3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE

Product Name
3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE
CAS No.
218137-86-1
Chemical Name
3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE
Synonyms
C75;C75（218137-86-1）;C75, 10 mM in DMSO;FAS inhibitor C75 (C-75;C75 >=98% (HPLC), powder;3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE;TRANS-4-CARBOXY-5-OCTYL-3-METHYLENEBUTYROLACTONE;3-Furancarboxylic acid, tetrahydro-4-methylene-2-octyl-5-oxo-;C75(4-Methylene-2-octyl-5-oxo-tetrahydro-furan-3-carboxylicacid);TRANS-TETRAHYDRO-3-METHYLENE-2-OXO-5-N-OCTYL-4-FURANCARBOXYLIC ACID
CBNumber
CB2114165
Molecular Formula
C14H22O4
Formula Weight
254.32
MOL File
218137-86-1.mol
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3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE Property

Boiling point:
432.1±45.0 °C(Predicted)
Density 
1.08±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 18 mg/mL
form 
solid
pka
3.08±0.40(Predicted)
color 
off-white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C5490
Product name
C75
Purity
≥98% (HPLC), powder
Packaging
5mg
Price
$354.35
Updated
2025/07/31
Sigma-Aldrich
Product number
C5490
Product name
C75
Purity
≥98% (HPLC), powder
Packaging
25mg
Price
$1430
Updated
2025/07/31
Tocris
Product number
2489
Product name
C75
Purity
≥99%(HPLC)
Packaging
10
Price
$227
Updated
2021/12/16
Usbiological
Product number
254848
Product name
C 75
Packaging
10mg
Price
$480
Updated
2021/12/16
ChemScene
Product number
CS-3562
Product name
C75
Purity
99.91%
Packaging
5mg
Price
$120
Updated
2021/12/16
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3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE Chemical Properties,Usage,Production

Uses

C75 has been used:

  • as a fatty acid synthase (FASN) inhibitor to test its ability in the direct inhibition of FASN to attenuate mammosphere formation as compared to metformin
  • as a pharmacological inhibitor to inhibit fatty acid synthesis in glioma stem cells (GSCs)
  • as FAS inhibitor in the pre-treatment of Chang cells to inhibit lipogenesis and reverse the senescence induced by hydrogen peroxide

Definition

ChEBI: 4-methylene-2-octyl-5-oxo-3-oxolanecarboxylic acid is a gamma-lactone.

Biochem/physiol Actions

C75 helps to increase the cancer‐killing capability of ionizing radiation.

in vivo

C75 blocks fasting-induced c-Fos expression in the arcuate nucleus (Arc), lateral hypothalamic area (LHA), and paraventricular nucleus (PVN) 10–24 h after i.p. injection. Intraperitoneal administration of C75 at 30 mg/kg body weight inhibits food intake of mice by ≥95% within 2 h after i.p. injection[3]. C75-treated DIO mice has a 50% greater weight loss, and a 32.9% increased production of energy because of fatty acid oxidation. C75 treatment of rodent adipocytes and hepatocytes and human breast cancer cells increases fatty acid oxidation and ATP levels by increasing CPT-1 activity, even in the presence of elevated concentrations of malonyl-CoA[4].

3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE Suppliers

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218137-86-1, 3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONERelated Search:

BUTTPARK 27\04-75 BUTTPARK 4\01-75 BUTTPARK 30\09-75 BUTTPARK 23\07-75 BUTTPARK 32\01-75 BUTTPARK 35\03-75 BUTTPARK 31\08-75 BUTTPARK 43\57-75 BUTTPARK 33\08-75 BUTTPARK 18\01-75 BUTTPARK 153\33-75 BUTTPARK 34\07-75 BUTTPARK 37\11-75 BUTTPARK 29\09-75 16:0 PC D75 BUTTPARK 16\04-75 BUTTPARK 26\07-75 BUTTPARK 152\40-75

  • 3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE
  • C75
  • C75(4-Methylene-2-octyl-5-oxo-tetrahydro-furan-3-carboxylicacid)
  • TRANS-4-CARBOXY-5-OCTYL-3-METHYLENEBUTYROLACTONE
  • TRANS-TETRAHYDRO-3-METHYLENE-2-OXO-5-N-OCTYL-4-FURANCARBOXYLIC ACID
  • FAS inhibitor C75 (C-75
  • 3-Furancarboxylic acid, tetrahydro-4-methylene-2-octyl-5-oxo-
  • C75 >=98% (HPLC), powder
  • C75, 10 mM in DMSO
  • C75（218137-86-1）
  • 218137-86-1
  • Fatty acid synthase
  • Enzyme Inhibitors by Enzyme
  • Enzymes, Inhibitors, and Substrates
  • D to K
  • Enzyme Inhibitors
  • Biochemicals and Reagents
  • BioChemical