(UNDECYLTHIO)-ACETIC ACID
- Product Name
- (UNDECYLTHIO)-ACETIC ACID
- CAS No.
- 116296-31-2
- Chemical Name
- (UNDECYLTHIO)-ACETIC ACID
- Synonyms
- 3-TDA;3-THIATETRADECANOIC ACID;(UNDECYLTHIO)-ACETIC ACID;CZSSKBQAJULWPY-UHFFFAOYSA-N;Acetic acid, 2-(undecylthio)-
- CBNumber
- CB2114822
- Molecular Formula
- C13H26O2S
- Formula Weight
- 246.41
- MOL File
- 116296-31-2.mol
(UNDECYLTHIO)-ACETIC ACID Property
- Melting point:
- 61-62 °C
- Boiling point:
- 359.0±25.0 °C(Predicted)
- Density
- 0.978±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
- form
- crystalline solid
- pka
- 3.85±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 90500
- Product name
- 3-Thiatetradecanoic Acid
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $48
- Updated
- 2024/03/01
- Product number
- 90500
- Product name
- 3-Thiatetradecanoic Acid
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $210
- Updated
- 2024/03/01
- Product number
- 90500
- Product name
- 3-Thiatetradecanoic Acid
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $371
- Updated
- 2024/03/01
- Product number
- C5280
- Product name
- 3-ThiatetradecanoicAcid
- Packaging
- 10mg
- Price
- $422
- Updated
- 2021/12/16
- Product number
- C5280
- Product name
- 3-ThiatetradecanoicAcid
- Packaging
- 5mg
- Price
- $237
- Updated
- 2021/12/16
(UNDECYLTHIO)-ACETIC ACID Chemical Properties,Usage,Production
Biological Activity
3-thiatetradecanoic acid is an activator of ppar.the peroxisome proliferator-activated receptors (ppars) are transcription factors involved in fatty acid metabolism and energy homeostasis. the ppars also play crucial roles in the control of cellular growth and differentiation.
in vitro
in bt4cn cells, 3-thiatetradecanoic acid could activate all ppar subtypes dose-dependently. in cell culture experiments, the pparγ-selective ligand brl49653 moderately inhibited growth of bt4cn cells, while administration of 3-thiatetradecanoic acid led to a marked growth inhibition. moreover, the administration of the pparγ-selective antagonist gw9662 abolished brl49653-induced growth inhibition, but only marginally reduced the effect of 3-thiatetradecanoic acid [1].
in vivo
administration of 3-thiatetradecanoic acid increased mitochondrial and peroxisomal beta-oxidative capacity and carnitine palmitoyltransferase activity, but reduced free fatty acid and triacylglycerol levels in plasma compared to palmitic acid-treated rats and controls. 3-thiatetradecanoic acid administration was able to affect the fatty acid composition in plasma and liver by increasing the amount of monoenes [2].
References
1. berge k, tronstad kj, flindt en, rasmussen th, madsen l, kristiansen k, berge rk. tetradecylthioacetic acid inhibits growth of rat glioma cells ex vivo and in vivo via ppar-dependent and ppar-independent pathways. carcinogenesis. 2001 nov;22(11):1747-55.2. asiedu, d.k.,froyland, l.,vaagenes, h., et al. long-term effect of tetradecylthioacetic acid: a study on plasma lipid profile and fatty acid composition and oxidation in different rat organs. biochimica et biophysica acta 1300, 86-96 (1996).3. pettersen rj, salem m, skorve j, ulvik rj, berge rk, nordrehaug je. pharmacology and safety of tetradecylthioacetic acid (tta): phase-1 study. j cardiovasc pharmacol. 2008 apr;51(4):410-7.
(UNDECYLTHIO)-ACETIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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