ChemicalBook > CAS DataBase List > CERIVASTATIN SODIUM

CERIVASTATIN SODIUM

Product Name: CERIVASTATIN SODIUM
CAS No.: 145599-86-6
Chemical Name: CERIVASTATIN SODIUM
Synonyms: BAYCOL;LIPOBAY;RIVASTATIN;Cerivastatin;CERIVASTATIN NA;CERIVASTATIN, SODIUM SALT;Cerivastatin See C277000;CERIVASTATIN SODIUM USP/EP/BP;7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-dipropan-2-yl-pyrid in-3-yl]-3,5-dihydroxy-hept-6-enoate;6-[2-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-di(propan-2-yl)-3-pyridinyl]ethenyl]-4-hydroxy-2-oxanone
CBNumber: CB2115263
Molecular Formula: C26H34FNO5
Formula Weight: 459.55
MOL File: 145599-86-6.mol

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CERIVASTATIN SODIUM Property

Melting point:: >176oC (dec.)
Boiling point:: 646.3±55.0 °C(Predicted)
Density: 1.181±0.06 g/cm3(Predicted)
storage temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility: Ethanol (Slightly), Methanol (Slightly), Water (Slightly)
form: Solid
pka: pKa 4.38 (H2O t=25 I=0.025) (Uncertain);5.29(H2O t=25 I=0.025) (Uncertain)
color: White to Off-White
Stability:: Hygroscopic
CAS DataBase Reference: 145599-86-6(CAS DataBase Reference)
EPA Substance Registry System: 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1- methylethyl)-3-pyridinyl]-3,5-dihydroxy-, (3R,5S,6E)- (145599-86-6)

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Safety

Hazardous Substances Data: 145599-86-6(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: C2830
Product name: Cerivastatin, Sodium Salt
Packaging: 5mg
Price: $396
Updated: 2021/12/16

AHH

Product number: MT-49111
Product name: Cerivastatin
Purity: 98%
Packaging: 0.1g
Price: $410
Updated: 2021/12/16

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CERIVASTATIN SODIUM Chemical Properties,Usage,Production

Uses

assimilate cholesterol

Definition

ChEBI: (3R,5S)-3,5-dihydroxyhept-6-enoic acid in which the (7E)-hydrogen is substituted by a 4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)pyridin-3-yl group. Formerly used (as its sodium salt) to lower cho esterol and prevent cardiovascular disease, it was withdrawn from the market worldwide in 2001 following reports of a severe form of muscle toxicity.

brand name

Baycol (Bayer);Cholstat.

in vivo

Cerivastatin is well absorbed, reaching maximal plasma levels in 1-3 hours following oral dosing. In the circulation, Cerivastatin is highly bound to plasma proteins (99.5%), with an elimination half-life of 2-4 hours. Cerivastatin is metabolized predominantly in the liver to three polar metabolites. Two of these metabolites are active, but to a lesser extent compared to parent drug, and the third metabolite is inactive. Plasma concentrations of all metabolites are substantially lower than those of the parent drug. Elimination of metabolites is via the urine (20-25%) and feces (66-73%), while essentially no parent compound is excreted^[2].

CERIVASTATIN SODIUM Preparation Products And Raw materials

Raw materials

Preparation Products

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145599-86-6, CERIVASTATIN SODIUMRelated Search:

Pitavastatin Azathioprine Rofecoxib Cisapride Nifedipine Oxygen 3-HEPTENOIC ACID Sodium Fluorine Cerivastatin sodium 3-METHYL-5-VINYLPYRIDINE CERIVASTATIN SODIUM

RIVASTATIN

sodium 7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-dipropan-2-yl-pyrid in-3-yl]-3,5-dihydroxy-hept-6-enoate

LIPOBAY

BAYCOL

CERIVASTATIN NA

CERIVASTATIN, SODIUM SALT

7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-dipropan-2-yl-pyrid in-3-yl]-3,5-dihydroxy-hept-6-enoate

(3R,5S,6E)-7-[4-(p-Fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)-3-pyridyl]-3,5-dihydroxy-6-heptenoic acid

6-Heptenoic acid, 7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-, (3R,5S,6E)-

6-Heptenoic acid, 7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-, [S-[R*,S*-(E)]]-

(3R,5S,6E)-7-[4-(4-Fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)-3-pyridyl]-3,5-dihydroxy-6-heptenoic acid

Cerivastatin

6-[2-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-di(propan-2-yl)-3-pyridinyl]ethenyl]-4-hydroxy-2-oxanone

CERIVASTATIN SODIUM USP/EP/BP

Cerivastatin See C277000

145599-86-6

C26H34FNO5

Active Pharmaceutical Ingredients