3b,5-Dihydroxy-6b,7b:15b,16b-dimethylene-5b-androstan-17-one
- Product Name
- 3b,5-Dihydroxy-6b,7b:15b,16b-dimethylene-5b-androstan-17-one
- CAS No.
- 82543-16-6
- Chemical Name
- 3b,5-Dihydroxy-6b,7b:15b,16b-dimethylene-5b-androstan-17-one
- Synonyms
- D8/Q5;3β,5-dihydroxy-6β,7β;3b,5-Dihydroxy-6b,7b;3β,5-dihydroxy-6β,7β;3β,5β-Dihydroxy-6β,7β;Drospirenone Impurity 5;Drospirenone Impurity N2;Drospirosterone impurity 15;Drospirenone intermediate Q5;3beta,5beta-dihydroxy-6beta,7beta
- CBNumber
- CB21176016
- Molecular Formula
- C21H30O3
- Formula Weight
- 330.46
- MOL File
- 82543-16-6.mol
3b,5-Dihydroxy-6b,7b:15b,16b-dimethylene-5b-androstan-17-one Property
- Melting point:
- 205-207°C
- Boiling point:
- 478.3±45.0 °C(Predicted)
- Density
- 1.286±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 14.59±0.70(Predicted)
- color
- White to Off-White
- InChIKey
- GWUFXQIQXPASJU-VJWUOOCFSA-N
- SMILES
- C1C[C@]2(C)[C@@]3([H])CC[C@@]4(C)[C@@]([H])([C@@H]5C[C@@H]5C4=O)[C@]3([H])[C@H]3C[C@H]3[C@]2(O)C[C@H]1O
N-Bromosuccinimide Price
- Product number
- J51802
- Product name
- 3beta,5-Dihydroxy-6beta,7beta;15beta,16beta-dimethylene-5beta-androstan-17-one
- Packaging
- 1g
- Price
- $58
- Updated
- 2021/12/16
- Product number
- FD22369
- Product name
- 6b,7b,15b,16b-Dimethylene-3b,5b-dihydroxyandrostan-17-one
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FD22369
- Product name
- 6b,7b,15b,16b-Dimethylene-3b,5b-dihydroxyandrostan-17-one
- Packaging
- 2g
- Price
- $95
- Updated
- 2021/12/16
- Product number
- FD22369
- Product name
- 6b,7b,15b,16b-Dimethylene-3b,5b-dihydroxyandrostan-17-one
- Packaging
- 5G
- Price
- $145
- Updated
- 2021/12/16
- Product number
- FD22369
- Product name
- 6b,7b,15b,16b-Dimethylene-3b,5b-dihydroxyandrostan-17-one
- Packaging
- 10g
- Price
- $226
- Updated
- 2021/12/16
3b,5-Dihydroxy-6b,7b:15b,16b-dimethylene-5b-androstan-17-one Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
Intermediate of Drospirenone.
Synthesis
82543-15-5
74-95-3
82543-16-6
Zinc powder (135.00 g, 2.065 mol) and copper (I) bromide (5.00 g, 0.035 mol) were suspended in 1,2-dimethoxyethane (1820 mL) under nitrogen protection. The mixture was heated to 75 °C and stirred for 20 min. Next, acetic acid (4.5 mL, 0.078 mol) and isopropanol (9.5 mL, 0.124 mol) were added to the system and stirred at 72 °C. A solution of dibromomethane (334 g, 1.921 mol) in 1,2-dimethoxyethane (114 mL) was added slowly dropwise, with the rate of acceleration of the drop being controlled to maintain the reaction temperature at about 75 °C. The reaction mixture was stirred for 1 hour until TLC analysis showed complete conversion of the feedstock. After addition of ethyl acetate (2500 mL), the system was cooled to 0-5 °C. A 5% aqueous acetic acid solution (2500mL) was added slowly and stirring was continued for 30 minutes. The solid was collected by filtration and the liquid phase was separated. The aqueous layer was extracted twice each with ethyl acetate (1250 mL, 500 mL) and the combined organic phases were washed twice with distilled water (2 x 2500 mL) and separated. The organic solvent was removed under reduced pressure at 45 °C and the residue was dissolved in diisopropyl ether (560 mL), stirred, filtered and washed twice with diisopropyl ether. The resulting (2S,4aR,4bS,6aS,7aS,8aS,8bS,8cR,8dR,9aR,9bR)-2.9b-dihydroxy-4a,6a-dimethyloctadecyl-7H-cyclopropa[4,5]cyclo-penta[1,2-a]cyclopropa[l]phenanthracenecarbenecarbenone 7-ketone was dried in vacuo at 45 °C to give the product 74.50 g (0.225 mol, 71% yield). The product was structurally confirmed by 1H-NMR and 13C-NMR, and HPLC-MS (ESI) analysis showed [M + Na]+ = 353 and [2M + Na]+ = 683.
References
[1] Patent: EP2019114, 2009, A1. Location in patent: Page/Page column 11
[2] Patent: US2005/192450, 2005, A1. Location in patent: Page/Page column 6-7
[3] Patent: EP1571153, 2005, A2. Location in patent: Page/Page column 4; 9; 14
3b,5-Dihydroxy-6b,7b:15b,16b-dimethylene-5b-androstan-17-one Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3b,5-Dihydroxy-6b,7b:15b,16b-dimethylene-5b-androstan-17-one manufacturers
- Product
- Q5 82543-16-6
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- ≥97.0%
- Supply Ability
- 10kg/month
- Release date
- 2021-06-21
- Product
- Drospirenone Impurity 15 82543-16-6
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 95
- Supply Ability
- 1000000
- Release date
- 2025-02-14
- Product
- 15β,16β-dimethylene-5β-androst-17-one 82543-16-6
- Price
- US $40.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10 tons
- Release date
- 2023-09-19