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Chlorthalidone Impurity G

Product Name
Chlorthalidone Impurity G
CAS No.
16289-13-7
Chemical Name
Chlorthalidone Impurity G
Synonyms
Chloro Chlorthalidone;Chlortalidone Impurity G;Chlorthalidone Impurity G;Chlorthalidone EP Impurity G;Chlortalidone EP Impurity G;Chlortalidone (Chlorthalidone) EP Impurity G;3-(3,4-Dichlorophenyl)-3-hydroxy-phthalimidin;(3-(3,4-Dichlorophenyl)-3-hydroxy-phthalimidine);3-(3,4-Dichlorophenyl)-3-hydroxyisoindolin-1-one;3-(3,4-dichlorophenyl)-3-hydroxy-2H-isoindol-1-one
CBNumber
CB21176203
Molecular Formula
C14H9Cl2NO2
Formula Weight
294.13
MOL File
16289-13-7.mol
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Chlorthalidone Impurity G Property

Melting point:
197-2010C
storage temp. 
-20°C Freezer
solubility 
Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
White
CAS DataBase Reference
16289-13-7
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22574
Product name
Chlorthalidone Impurity G
Purity
≥98%
Packaging
1mg
Price
$97
Updated
2024/03/01
Cayman Chemical
Product number
22574
Product name
Chlorthalidone Impurity G
Purity
≥98%
Packaging
500μg
Price
$51
Updated
2023/01/06
Cayman Chemical
Product number
22574
Product name
Chlorthalidone Impurity G
Purity
≥98%
Packaging
5mg
Price
$146
Updated
2024/03/01
TRC
Product number
C427520
Product name
ChloroChlorthalidone
Packaging
10mg
Price
$180
Updated
2021/12/16
Biosynth Carbosynth
Product number
IC20415
Product name
Chlorthalidone impurity G
Packaging
2mg
Price
$200
Updated
2021/12/16
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Chlorthalidone Impurity G Chemical Properties,Usage,Production

Description

Chlorthalidone impurity G is a potential impurity found in commercial preparations of chlorthalidone that has moderate antihypertensive effects. Chlorthalidone is a thiazide-like diuretic that inhibits the Na+/Cl- cotransporter in the distal convoluted tubule of the kidney, which prevents reabsorption of sodium and chloride leading to a reduction in plasma volume and cardiac output. It also inhibits carbonic anhydrase (CA), including the isoforms CAVB, VII, IX, XII, and XIII (Kis = 2.8-23 nM) and, to a lesser extent, CAI, CAII, IV, VA, and VI (Kis = 138-1,347 nM), which may mediate its sustained vasodilatory activity. Dietary administration of chlorthalidone (8 mg per animal per day) reduces arterial hypertension and prevents or reduces ventricular hypertrophy in DOCA-salt hypertensive rats. Formulations containing chlorthalidone have been used alone or in combination with other antihypertensive agents to lower arterial blood pressure and as adjuvants to address edema caused by cardiac or renal disorders.

Chemical Properties

White Solid

Uses

Chlorthalidone impurity. Antihypertensive agent.

Chlorthalidone Impurity G Preparation Products And Raw materials

Raw materials

Preparation Products

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Chlorthalidone Impurity G Suppliers

Canada 1 China 27 India 11 United Kingdom 1 United States 5 Global 45
J & K SCIENTIFIC LTD.
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