Deracoxib

Product Name: Deracoxib
CAS No.: 169590-41-4
Chemical Name: Deracoxib
Synonyms: DeraM;Sc 46;Deramaxx;Sc 59046;Deracoxib;Deracoxib-d3;Unii-vx29jb5xwv;Deracoxib [usan];Deracoxib (SC 046;Deracoxib, 10 mM in DMSO
CBNumber: CB21178454
Molecular Formula: C17H14F3N3O3S
Formula Weight: 397.37
MOL File: 169590-41-4.mol

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Deracoxib Property

Melting point:: 159-161°
Boiling point:: 575.5±60.0 °C(Predicted)
Density: 1.48
storage temp.: 2-8°C
solubility: Acetonitrile (Slightly), DMSO (Slightly)
pka: 9.69±0.10(Predicted)
form: Solid
color: Light Brown

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2014
Product name: Deracoxib
Purity: ≥98% (HPLC)
Packaging: 50MG
Price: $105
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2014
Product name: Deracoxib
Purity: ≥98% (HPLC)
Packaging: 100MG
Price: $158
Updated: 2024/03/01

Cayman Chemical

Product number: 27371
Product name: Deracoxib
Packaging: 100mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 27371
Product name: Deracoxib
Packaging: 25mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 27371
Product name: Deracoxib
Packaging: 50mg
Price: $68
Updated: 2024/03/01

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Deracoxib Chemical Properties,Usage,Production

Uses

Deracoxib is a non-steroidal anti-inflammatory drug (NSAID) of the coxib class. Deracoxin is a selective cyclooxygenase-2 (COX-2) inhibitor used in the treatment of osteoarthritis in dogs. At low doses, adminsitartion of Deracoxin showed no factors associated with gastrointestinal tract perforation.

Definition

ChEBI: A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3, and 5 by 4-sulfamoylphenyl, difluoromethyl and 3-fluoro-4-methoxyphenyl groups, respectively. A selective cyclooxygenase 2 inhibitor, it is us d in veterinary medicine for the control of pain and inflammation associated with osteoarthritis in dogs.

Biological Activity

Deracoxib is an orally active cyclooxygenase-2 (COX-2) inhibitor with >48-fold selectivity over COX-1 (IC50 of 203-189 nM against COX-2-dependent PGE2 production vs. IC50 of 9.85-9.96 μM against COX-1-dependent TxB2 production in dog whole blood). Deracoxib is also reported to exhibit inhibitory activity against phosphodiesterase (Ki = 3.6 μM against human PDE4D3) as well as positive modulatory effiacy toward 2-APB-stimulated transient receptor potential vanilloid 3 channel (TRPV3) activity.

Veterinary Drugs and Treatments

Deracoxib is indicated for the treatment of post-operative pain (higher dose, 7 day maximum), and for the treatment of pain and inflammation associated with osteoarthritis (lower dose, ongoing dosing) in dogs.
Like piroxicam, deracoxib is of interest in adjunctive treatment of transitional cell carcinoma of the bladder; investigations into this use are ongoing.

Deracoxib Preparation Products And Raw materials

Raw materials

Preparation Products

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Deracoxib Suppliers

Canada 1 China 124 India 8 United Kingdom 1 United States 13 Global 147

MedChemexpress LLC

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Alfa Chemistry

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BOC Sciences

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Musechem

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TargetMol Chemicals Inc.

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InvivoChem

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Alchem Pharmtech,Inc.

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Aladdin Scientific

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ApexBio Technology

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Cayman Chemical Company

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MedChemExpress

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Matrix Scientific

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LKT Laboratories, Inc.

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View Lastest Price from Deracoxib manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Deracoxib 169590-41-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

169590-41-4, DeracoxibRelated Search:

Etoricoxib Valdecoxib 4-(3,5-DIMETHYL-PYRAZOL-1-YL)-BENZENESULFONAMIDE Deracoxib

Benzenesulfonamide, 4-3-(difluoromethyl)-5-(3-fluoro-4-methoxyphenyl)-1H-pyrazol-1-yl-

4-(3-(Difluoromethyl)-5-(3-fluoro-4-methoxyphenyl)-1H-pyrazol-1-yl)benzenesulfonamide

Deracoxib [usan]

Deramaxx

Sc 46

Sc 59046

Unii-vx29jb5xwv

4-[5-(3-Fluoro-4-Methoxyphenyl)-3-(difluoroMethyl)-1H-pyrazol-1-yl]benzenesulfonaMide

DeraM

Deracoxib-d3

Deracoxib

4-[3-(difluoromethyl)-5-(3-fluoro-4-methoxyphenyl)pyrazol-1-yl]benzenesulfonamide

Deracoxib (SC 046

Deracoxib, 10 mM in DMSO

169590-41-4