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Oosponol

Product Name
Oosponol
CAS No.
146-04-3
Chemical Name
Oosponol
Synonyms
Lenzitin;Oosponol;Brn 1287762;4-Glycolyl-8-hydroxyisocoumarin;Isocoumarin, 4-glycolyl-8-hydroxy-;4-(1-Oxo-2-hydroxyethyl)-8-hydroxyisocoumarin;8-Hydroxy-4-(hydroxyacetyl)-1H-2-benzopyran-1-one
CBNumber
CB21179385
Formula Weight
0
MOL File
146-04-3.mol
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Oosponol Property

LogP
0.789 (est)
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Safety

Toxicity
LD50 oral in rat: 250mg/kg
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
MTB0002157
Product name
OOSPONOL
Purity
95.00%
Packaging
5MG
Price
$502.71
Updated
2021/12/16
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Oosponol Chemical Properties,Usage,Production

Uses

Oosponol is a dopamine beta-hydroxylase inhibitor exhibiting hypotensive effects.Oospongol has strong antifungal activity against many antagonistic fungi[1][2].

in vivo

Oosponol (6.25 mg/kg, 3.1 mg/kg, ip, Once) can lower blood pressure in spontaneously hypertensive rats model[1].

Animal Model:Spontaneously hypertensive rats[1]
Dosage:6.25 mg/kg, 3.1 mg/kg
Administration:Intraperitoneal injection, once.
Result:The intraperitoneal injection of 6.25 mg/kg lowered the pressure from 186 mm to 138~112 mm, the intraperitoneal injection of 3.1 mg/kg lowered the pressure from 185 mm to 164~131 mm[1].
Animal Model:Spontaneously hypertensive rats[1]
Dosage:6.25 mg/kg, 3.1 mg/kg
Administration:Intraperitoneal injection, once.
Result:The intraperitoneal injection of 6.25 mg/kg lowered the pressure from 186 mm to 138~112 mm, the intraperitoneal injection of 3.1 mg/kg lowered the pressure from 185 mm to 164~131 mm.

References

[1] Umezawa H, et al.. Dopamine -hydroxylase inhibitor produced by Gloeophyllum striatum and its identity with oosponol. J Antibiot (Tokyo). 1972 Apr;25(4):239-42. DOI:10.7164/antibiotics.25.239
[2] Sonnenbichler J,et al. Influence of the Gloeophyllum metabolite oosponol and some synthetic analogues on protein and RNA synthesis in target cells. Eur J Biochem. 1997 May 15;246(1):45-9. DOI:10.1111/j.1432-1033.1997.t01-2-00045.x

Oosponol Preparation Products And Raw materials

Raw materials

Preparation Products

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Oosponol Suppliers

China 8 South Korea 1 United States 3 Global 12
Shanghai Haozhixiang Biotechnology Co., Ltd
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526763801 13301653310
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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BOC Sciences
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Zhejiang Huida Biotech Co., LTD
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Zhejiang Huida Biotech Co., LTD
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0571-0571-89903882 15990081639
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sunshixuan@huidabiotech.com
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TargetMol Chemicals Inc.
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4008200310
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Chengdu DeSiTe Biological Technology Co., Ltd
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TargetMol Chemicals Inc.
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146-04-3, OosponolRelated Search:

Oosponol METHYL 5-ACETYLSALICYLATE 1H-2-Benzopyran-1-one 5-ACETYLSALICYLIC ACID Methyl 5-formyl-2-hydroxybenzoate

  • Oosponol
  • 4-(1-Oxo-2-hydroxyethyl)-8-hydroxyisocoumarin
  • 4-Glycolyl-8-hydroxyisocoumarin
  • 8-Hydroxy-4-(hydroxyacetyl)-1H-2-benzopyran-1-one
  • Lenzitin
  • Brn 1287762
  • Isocoumarin, 4-glycolyl-8-hydroxy-
  • 146-04-3