Oosponol
- Product Name
- Oosponol
- CAS No.
- 146-04-3
- Chemical Name
- Oosponol
- Synonyms
- Lenzitin;Oosponol;Brn 1287762;4-Glycolyl-8-hydroxyisocoumarin;Isocoumarin, 4-glycolyl-8-hydroxy-;4-(1-Oxo-2-hydroxyethyl)-8-hydroxyisocoumarin;8-Hydroxy-4-(hydroxyacetyl)-1H-2-benzopyran-1-one
- CBNumber
- CB21179385
- Formula Weight
- 0
- MOL File
- 146-04-3.mol
Oosponol Property
- LogP
- 0.789 (est)
Safety
- Toxicity
- LD50 oral in rat: 250mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- MTB0002157
- Product name
- OOSPONOL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.71
- Updated
- 2021/12/16
Oosponol Chemical Properties,Usage,Production
Uses
Oosponol is a dopamine beta-hydroxylase inhibitor exhibiting hypotensive effects.Oospongol has strong antifungal activity against many antagonistic fungi[1][2].
in vivo
Oosponol (6.25 mg/kg, 3.1 mg/kg, ip, Once) can lower blood pressure in spontaneously hypertensive rats model[1].
| Animal Model: | Spontaneously hypertensive rats[1] |
| Dosage: | 6.25 mg/kg, 3.1 mg/kg |
| Administration: | Intraperitoneal injection, once. |
| Result: | The intraperitoneal injection of 6.25 mg/kg lowered the pressure from 186 mm to 138~112 mm, the intraperitoneal injection of 3.1 mg/kg lowered the pressure from 185 mm to 164~131 mm[1]. |
| Animal Model: | Spontaneously hypertensive rats[1] |
| Dosage: | 6.25 mg/kg, 3.1 mg/kg |
| Administration: | Intraperitoneal injection, once. |
| Result: | The intraperitoneal injection of 6.25 mg/kg lowered the pressure from 186 mm to 138~112 mm, the intraperitoneal injection of 3.1 mg/kg lowered the pressure from 185 mm to 164~131 mm. |
References
[1] Umezawa H, et al.. Dopamine -hydroxylase inhibitor produced by Gloeophyllum striatum and its identity with oosponol. J Antibiot (Tokyo). 1972 Apr;25(4):239-42. DOI:10.7164/antibiotics.25.239
[2] Sonnenbichler J,et al. Influence of the Gloeophyllum metabolite oosponol and some synthetic analogues on protein and RNA synthesis in target cells. Eur J Biochem. 1997 May 15;246(1):45-9. DOI:10.1111/j.1432-1033.1997.t01-2-00045.x
Oosponol Preparation Products And Raw materials
Raw materials
Preparation Products
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