ChemicalBook > CAS DataBase List > Pipequaline

Pipequaline

Product Name: Pipequaline
CAS No.: 77472-98-1
Chemical Name: Pipequaline
Synonyms: PK-8165;45319RP;RP-45319;Pipequaline;CAS_77472-98-1;pipequaline PK-8165;PK-8165; PK8165; PK 8165;pipequaline HCI(PK-8165);pipequaline.HCl(for free base);2-phenyl-4-(2-piperidin-4-ylethyl)quinoline
CBNumber: CB21179512
Molecular Formula: C22H24N2
Formula Weight: 316.44
MOL File: 77472-98-1.mol

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Pipequaline Property

Boiling point:: 489.2±30.0 °C(Predicted)
Density: 1.078±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 10 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml
form: A crystalline solid
pka: 10.60±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23888
Product name: Pipequaline
Purity: ≥98%
Packaging: 10mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 23888
Product name: Pipequaline
Purity: ≥98%
Packaging: 50mg
Price: $356
Updated: 2024/03/01

Cayman Chemical

Product number: 23888
Product name: Pipequaline
Purity: ≥98%
Packaging: 100mg
Price: $593
Updated: 2024/03/01

AK Scientific

Product number: 4345CA
Product name: Pipequaline
Packaging: 100mg
Price: $758
Updated: 2021/12/16

ChemScene

Product number: CS-6386
Product name: Pipequaline
Purity: 99.77%
Packaging: 50mg
Price: $280
Updated: 2021/12/16

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Pipequaline Chemical Properties,Usage,Production

Description

Pipequaline is a partial agonist of central benzodiazepine receptors (K_i = 78 nM in a radioligand binding assay). In mice, pipequaline enhances the effects of diazepam , further reducing foot shock-induced fighting behavior and the number of maximal electroshock-induced seizures and potentiating the muscle relaxant and hypnotic effects. Pipequaline also increases drinking in the Vogel punished drinking task indicating anxiolytic-like activity that can be reversed by the benzodiazepine receptor antagonist flumazenil .

Uses

Pipequaline (PK 8165) is a partial benzodiazepine receptor agonist with anxiolytic activity[1][2].

in vivo

Intravenously administered pipequaline exerts a partial suppression of activations by kainate, glutamate and acetylcholine. Microiontophoretic applications of pipequaline reduces the neuronal activation by kainate^[2]. Pipequaline produces dose-related decreases in motor activity. Pipequaline produces significant dose-related decreases in the number of head-dips made^[3].

References

[1] Bradwejn J, et al. Effects of PK 8165, a partial benzodiazepine receptor agonist, on cholecystokinin-inducedactivation of hippocampal pyramidal neurons: a microiontophoretic study in the rat. Eur J Pharmacol. 1985 Jun 19;112(3):415-8. DOI:10.1016/0014-2999(85)90790-3
[2] Debonnel G, et al. Pipequaline acts as a partial agonist of benzodiazepine receptors: an electrophysiological study in the hippocampus of the rat. Neuropharmacology. 1987 Sep;26(9):1337-42. DOI:10.1016/0028-3908(87)90096-7

Pipequaline Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Pipequaline manufacturers

Career Henan Chemical Co

Product: Pipequaline 77472-98-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 100kg
Release date: 2019-12-25

77472-98-1, PipequalineRelated Search:

Prazosin Pipequaline Quinoline, 6-methoxy-2-phenyl-4-(2-(4-piperidinyl)ethyl)-, monohydroch loride 1-(6-Methyl-2-phenyl-4-quinolinyl)-2-(4-piperidinyl)ethanone Piperacillin sodium salt Perhexiline

Pipequaline

PK-8165; PK8165; PK 8165

2-phenyl-4-(2-piperidin-4-ylethyl)quinoline

CAS_77472-98-1

2-Phenyl-4-[2-(4-piperidinyl)ethyl]quinoline

45319RP

PK-8165

RP-45319

pipequaline PK-8165

pipequaline.HCl(for free base)

pipequaline HCI(PK-8165)

Quinoline, 2-phenyl-4-[2-(4-piperidinyl)ethyl]-

77472-98-1