8-bromo-5-fluoroquinoline

Uses

Product Name: 8-bromo-5-fluoroquinoline
CAS No.: 917251-99-1
Chemical Name: 8-bromo-5-fluoroquinoline
Synonyms: 8-bromo-5-fluoroquinoline;Quinoline, 8-bromo-5-fluoro-
CBNumber: CB21180471
Molecular Formula: C9H5BrFN
Formula Weight: 226.05
MOL File: 917251-99-1.mol

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8-bromo-5-fluoroquinoline Property

Boiling point:: 294.2±20.0 °C(Predicted)
Density: 1.647±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 1.35±0.29(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2933491090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

TRC

Product number: B693428
Product name: 8-Bromo-5-fluoroquinoline
Packaging: 250mg
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: PC200497
Product name: 8-Bromo-5-fluoroquinoline
Packaging: 1g
Price: $146
Updated: 2021/12/16

Matrix Scientific

Product number: 115197
Product name: 8-Bromo-5-fluoroquinoline
Purity: >97%
Packaging: 500mg
Price: $203
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-B-0N
Product name: 8-Bromo-5-fluoroquinoline
Packaging: 1g
Price: $234
Updated: 2021/12/16

Matrix Scientific

Product number: 115197
Product name: 8-Bromo-5-fluoroquinoline
Purity: >97%
Packaging: 1g
Price: $278
Updated: 2021/12/16

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8-bromo-5-fluoroquinoline Chemical Properties,Usage,Production

Uses

8-Bromo-5-fluoroquinoline is used as a novel binder in the synthesis of 5HT1A, and also acts as a receptor antagonist and agonist. This drug has excellent efficacy for central nervous system disorders, such as cognitive impairment, anxiety disorders, depression, and sexual dysfunction.

Synthesis

1003-99-2

56-81-5

917251-99-1

2-Bromo-5-fluoroaniline (100 g, 1.0 eq.), 4-nitrophenol (40 g, 0.54 eq.) and glycerol (97 g, 2.0 eq.) were slowly added to pre-mixed sulfuric acid (267 mL) and water (114 mL) at 140-150 °C and the reaction lasted for 1.5 h. The reaction was carried out by HPLC. At the beginning of the reaction, the relative area percentage of 4-nitrophenol was shown to be 37.8% by HPLC analysis. The content of 4-nitrophenol decreased to 4.7% after the addition of 50% of the feedstock and further decreased to 5.0% after the addition of all the feedstock. Upon completion of the reaction, 8-bromo-5-fluoroquinoline was obtained after post-treatment in 87.5% yield with 0.29% total impurities. In addition, reducing the amount of 4-nitrophenol to 0.46 equivalents (34 g) was also successful in synthesizing the target intermediate in acceptable yield.

References

[1] Patent: US2007/27160, 2007, A1. Location in patent: Page/Page column 66
[2] Patent: US2007/299083, 2007, A1. Location in patent: Page/Page column 9
[3] Patent: WO2007/146072, 2007, A2. Location in patent: Page/Page column 73-74
[4] Patent: WO2008/67390, 2008, A2. Location in patent: Page/Page column 101-102
[5] Patent: US2007/27160, 2007, A1. Location in patent: Page/Page column 63-65

8-bromo-5-fluoroquinoline Preparation Products And Raw materials

Raw materials

Preparation Products

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8-bromo-5-fluoroquinoline Suppliers

China 77 Germany 2 India 1 United Kingdom 1 United States 5 Global 86

Energy Chemical

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View Lastest Price from 8-bromo-5-fluoroquinoline manufacturers

Career Henan Chemical Co

Product: 8-bromo-5-fluoroquinoline 917251-99-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98-100%
Supply Ability: 1000kg
Release date: 2018-08-20

917251-99-1, 8-bromo-5-fluoroquinolineRelated Search:

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8-bromo-5-fluoroquinoline

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917251-99-1