ChemicalBook > CAS DataBase List > ETHYL IMIDAZO[2,1-B][1,3]THIAZOLE-6-CARBOXYLATE

ETHYL IMIDAZO[2,1-B][1,3]THIAZOLE-6-CARBOXYLATE

Product Name
ETHYL IMIDAZO[2,1-B][1,3]THIAZOLE-6-CARBOXYLATE
CAS No.
64951-04-8
Chemical Name
ETHYL IMIDAZO[2,1-B][1,3]THIAZOLE-6-CARBOXYLATE
Synonyms
SKL392;ETHYL IMIDAZO[1,2-A]THIAZOLE-6-CARBOXYLATE;Ethyl imidazo[2,1-b]thiazole-6-carboxylate;6-(Ethoxycarbonyl)imidazo[2,1-b][1,3]thiazole;ETHYL IMIDAZO[2,1-B][1,3]THIAZOLE-6-CARBOXYLATE;Ethylimidazo[2,1-b][1,3]thiazole-6-carboxylate97%;Ethyl imidazo[2,1-b][1,3]thiazole-6-carboxylate 97%;IMIDAZO[2,1-B]THIAZOLE-6-CARBOXYLIC ACID ETHYL ESTER
CBNumber
CB2120201
Molecular Formula
C8H8N2O2S
Formula Weight
196.23
MOL File
64951-04-8.mol
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ETHYL IMIDAZO[2,1-B][1,3]THIAZOLE-6-CARBOXYLATE Property

Melting point:
87 °C
CAS DataBase Reference
64951-04-8
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Safety

Hazard Note 
Harmful
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
E940308
Product name
EthylImidazo[2,1-B]thiazole-6-carboxylate
Packaging
10mg
Price
$45
Updated
2021/12/16
TRC
Product number
E940308
Product name
EthylImidazo[2,1-B]thiazole-6-carboxylate
Packaging
50mg
Price
$60
Updated
2021/12/16
SynQuest Laboratories
Product number
8H70-1-U1
Product name
Ethyl imidazo[2,1-b][1,3]thiazole-6-carboxylate
Purity
97%
Packaging
1g
Price
$144
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
COR0004062
Product name
ETHYL IMIDAZO[2,1-B][1,3]THIAZOLE-6-CARBOXYLATE
Purity
95.00%
Packaging
1G
Price
$197.25
Updated
2021/12/16
Matrix Scientific
Product number
071819
Product name
Ethyl imidazo[2,1-b]thiazole-6-carboxylate
Purity
95+%
Packaging
1g
Price
$231
Updated
2021/12/16
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ETHYL IMIDAZO[2,1-B][1,3]THIAZOLE-6-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

96-50-4

70-23-5

64951-04-8

General procedure for the synthesis of ethylimidazo[2,1-b]thiazole-6-carboxylic acid from 2-aminothiazole (0.500 g, 5 mmol) and ethyl 3-bromopyruvate (90%, 1.625 g, 7.5 mmol): firstly, 2-amino thiazole was dissolved in tetrahydrofuran, followed by the addition of ethyl 3-bromopyruvate dropwise. The reaction mixture was stirred at room temperature for 8 hours before the precipitate was collected by filtration. The resulting filter cake was dissolved in hot ethanol and refluxed at 80°C for 8 hours. After completion of the reaction, the mixture was cooled and the solvent was removed by distillation. The residual solid was washed with cold water and filtered. After drying under vacuum, the intermediate (0.375 g) was obtained, which was dissolved in tetrahydrofuran. The yield of this step was 38.27%.

References

[1] Journal of Medicinal Chemistry, 2003, vol. 46, # 18, p. 3914 - 3929
[2] Journal of Medicinal Chemistry, 2015, vol. 58, # 6, p. 2764 - 2778
[3] Patent: CN105985356, 2016, A. Location in patent: Paragraph 0117; 0118
[4] Farmaco, Edizione Scientifica, 1977, vol. 32, # 10, p. 735 - 746
[5] Patent: US2010/249071, 2010, A1. Location in patent: Page/Page column 45

ETHYL IMIDAZO[2,1-B][1,3]THIAZOLE-6-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL IMIDAZO[2,1-B][1,3]THIAZOLE-6-CARBOXYLATE Suppliers

Belgium 1 China 34 Germany 1 India 1 United Kingdom 2 United States 12 Global 51
J & K SCIENTIFIC LTD.
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Pure Chemistry Scientific Inc.
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001-857-928-2050 or 1-888-588-9418
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sales@chemreagents.com
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Thermo Fisher Scientific
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800-810-5118
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+86-10-84193589
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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
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025-66113011 17798518460
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(1)02557626880
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Shanghai Witofly Chemical Co.,Ltd
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ShangHai Yuchuan Pharmaceutical Technology Co., Ltd.
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Shanghai Boyners Pharm-Tech Co., Ltd.
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Yancheng Schiemann Biological Technology Co.,Ltd
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64951-04-8, ETHYL IMIDAZO[2,1-B][1,3]THIAZOLE-6-CARBOXYLATERelated Search:

IMIDAZO[2,1-B]THIAZOLE-6-CARBALDEHYDE 4-ETHOXYCARBONYLIMIDAZOLE-2-THIOL (2-MERCAPTO-1-METHYL-1H-IMIDAZOL-5-YL)METHANOL ETHYL IMIDAZO[2,1-B][1,3]THIAZOLE-6-CARBOXYLATE 3-METHYLIMIDAZO[2,1-B]THIAZOLE-6-CARBOXYLIC ACID ETHYL ESTER IMIDAZO[2,1-B]THIAZOL-6-YLMETHANOL Imidazo[2,1-b][1,3]thiazole-6-carboxylic acid

  • Ethyl imidazo[2,1-b][1,3]thiazole-6-carboxylate 97%
  • Ethyl imidazo[2,1-b]thiazole-6-carboxylate
  • IMIDAZO[2,1-B]THIAZOLE-6-CARBOXYLIC ACID ETHYL ESTER
  • ETHYL IMIDAZO[1,2-A]THIAZOLE-6-CARBOXYLATE
  • ETHYL IMIDAZO[2,1-B][1,3]THIAZOLE-6-CARBOXYLATE
  • 6-(Ethoxycarbonyl)imidazo[2,1-b][1,3]thiazole
  • Ethylimidazo[2,1-b][1,3]thiazole-6-carboxylate97%
  • SKL392
  • 64951-04-8