1,4-DICHLOROPYRIDO[4,3-D]PYRIDAZINE

Uses

Product Name: 1,4-DICHLOROPYRIDO[4,3-D]PYRIDAZINE
CAS No.: 14490-19-8
Chemical Name: 1,4-DICHLOROPYRIDO[4,3-D]PYRIDAZINE
Synonyms: 3-d]pyridazine;4-dichloropyrido[4;1,4-dichloropyrido[3,4-d]pyridazine;1,4-DICHLOROPYRIDO[4,3-D]PYRIDAZINE;Pyrido[3,4-d]pyridazine, 1,4-dichloro-;1,4-DICHLOROPYRIDO[4,3-D]PYRIDAZINE 14490-19-8;1,4-DICHLOROPYRIDO[4,3-D]PYRIDAZINE ISO 9001：2015 REACH
CBNumber: CB21215838
Molecular Formula: C7H3Cl2N3
Formula Weight: 200.02
MOL File: 14490-19-8.mol

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1,4-DICHLOROPYRIDO[4,3-D]PYRIDAZINE Property

Melting point:: 159 °C
Boiling point:: 440.8±40.0 °C(Predicted)
Density: 1.573±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
pka: 1.19±0.30(Predicted)
color: Pale yellow
InChI: InChI=1S/C7H3Cl2N3/c8-6-4-1-2-10-3-5(4)7(9)12-11-6/h1-3H
InChIKey: LMVNXZZDBBSCSG-UHFFFAOYSA-N
SMILES: C1(Cl)=NN=C(Cl)C2=CC=NC=C12

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D438398
Product name: 1,4-Dichloropyrido[4,3-d]pyridazine
Packaging: 500mg
Price: $330
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD140879
Product name: 1,4-Dichloropyrido[4,3-d]pyridazine
Packaging: 1g
Price: $350
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD140879
Product name: 1,4-Dichloropyrido[4,3-d]pyridazine
Packaging: 2g
Price: $595
Updated: 2021/12/16

AK Scientific

Product number: W3159
Product name: 1,4-Dichloropyrido[4,3-d]pyridazine
Packaging: 5g
Price: $651
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0356685
Product name: 1,4-DICHLOROPYRIDO[4,3-D]PYRIDAZINE
Purity: 95.00%
Packaging: 5MG
Price: $499.57
Updated: 2021/12/16

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1,4-DICHLOROPYRIDO[4,3-D]PYRIDAZINE Chemical Properties,Usage,Production

Uses

1,4-Dichloropyrido[4,3-d]pyridazine is a useful research chemical.

Synthesis

31384-08-4

14490-19-8

General procedure for the synthesis of 1,4-dichloropyrido[4,3-D]pyridazine from 1,4-dihydroxypyrido[4,3-D]pyridazine: pyrido[3,4-d]pyridazine-1,4-diol (1.83 g, 11.2 mmol) and phosphorus trichloride (8.4 mL, 89.7 mmol) were added to a round bottomed flask. N,N-diisopropylethylamine (DIPEA, 2.0 mL, 11.2 mmol) was slowly added to the reaction system. The resulting suspension was heated and refluxed at 100 °C for 1 h. The reaction solution was gradually transformed into a brown solution. Upon completion of the reaction, the excess phosphorus trichloride was removed by rotary evaporator. The residue was dissolved in dichloromethane (DCM) and added slowly and dropwise to a mixed system of ice-water mixture and saturated aqueous sodium bicarbonate (NaHCO3). The saturated NaHCO3 solution was continued to be added dropwise until the aqueous phase was neutral. The organic and aqueous phases were separated and the aqueous phase was further extracted with dichloromethane (500 mL). The organic phases were combined, dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to afford the target product 1,4-dichloropyrido[3,4-d]pyridazine (1.74 g, 8.7 mmol, 78% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 9.78 (d, J = 0.9 Hz, 1H), 9.27 (d, J = 5.7 Hz, 1H), 8.09 (dd, J = 5.7 Hz, 0.9 Hz, 1H). Mass spectrometry analysis (Method 2): retention time (RT) 1.16 min, electrospray positive ionization mode (ES+) m/z 209.0 [M + H]+.

References

[1] Patent: WO2015/1348, 2015, A1. Location in patent: Paragraph 00183
[2] Patent: WO2014/191737, 2014, A1. Location in patent: Paragraph 00234
[3] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 15, p. 4607 - 4610
[4] Patent: WO2009/35568, 2009, A1. Location in patent: Page/Page column 41
[5] Patent: WO2009/35568, 2009, A1. Location in patent: Page/Page column 40-41

1,4-DICHLOROPYRIDO[4,3-D]PYRIDAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1,4-DICHLOROPYRIDO[4,3-D]PYRIDAZINE Suppliers

China 80 China Hong Kong 1 Germany 2 India 1 United Kingdom 1 United States 11 Global 96

QINGDAO CARELONGPHARMATECH CO.,LTD

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Capot Chemical Co., Ltd

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Shanghai Hanhong Scientific Co.,Ltd.

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Country: China
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Jinan Trio PharmaTech Co., Ltd.

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Shanghai T&W Pharmaceutical Co., Ltd.

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Shanghai potentpharm CO.,Ltd

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View Lastest Price from 1,4-DICHLOROPYRIDO[4,3-D]PYRIDAZINE manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 1,4-DICHLOROPYRIDO[4,3-D]PYRIDAZINE 14490-19-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-01

Dideu Industries Group Limited

Product: 1,4-DICHLOROPYRIDO[4,3-D]PYRIDAZINE 14490-19-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-11-02

Career Henan Chemical Co

Product: 1,4-DICHLOROPYRIDO[4,3-D]PYRIDAZINE 14490-19-8
Price: US $5.00/KG
Min. Order: 5KG
Purity: 99%
Supply Ability: 1ton
Release date: 2019-08-02

14490-19-8, 1,4-DICHLOROPYRIDO[4,3-D]PYRIDAZINERelated Search:

1,4-DICHLOROPYRIDO[4,3-D]PYRIDAZINE PYRIDO[3,4-D]PYRIDAZINE 1-CHLOROPYRIDO[3,4-D]PYRIDAZINE 4-CHLOROPYRIDO[3,4-D]PYRIDAZINE

1,4-DICHLOROPYRIDO[4,3-D]PYRIDAZINE

3-d]pyridazine

4-dichloropyrido[4

1,4-dichloropyrido[3,4-d]pyridazine

Pyrido[3,4-d]pyridazine, 1,4-dichloro-

1,4-DICHLOROPYRIDO[4,3-D]PYRIDAZINE 14490-19-8

1,4-DICHLOROPYRIDO[4,3-D]PYRIDAZINE ISO 9001：2015 REACH

14490-19-8

C11H15BrClNO

CHIRAL CHEMICALS