3-Methoxypyridine-5-boronic acid pinacol ester
- Product Name
- 3-Methoxypyridine-5-boronic acid pinacol ester
- CAS No.
- 445264-60-8
- Chemical Name
- 3-Methoxypyridine-5-boronic acid pinacol ester
- Synonyms
- 5-methoxypyridine-3-boryl ester;5-methoxy-3-pyridine borate acid;pyridineboronic acid pinacol ester;3-Methoxy-5-(pinacolboranato)pyridine;Methoxypyridine-3-boronic acid,pinacolester;5-Methoxy-3-pyridylboronic Acid Pinacol Ester;3-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER;(3-Methoxypyridin-5-yl)boronic acid pinacol est;(5-Methoxypyridin-3-yl)boronic acid pinacol ester;(3-Methoxypyridin-5-yl)boronic acid pinacol ester
- CBNumber
- CB21229288
- Molecular Formula
- C12H18BNO3
- Formula Weight
- 235.09
- MOL File
- 445264-60-8.mol
3-Methoxypyridine-5-boronic acid pinacol ester Property
- Melting point:
- 100-108℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder to crystal
- color
- White to Almost white
- InChIKey
- HENXUFOAGXNWKH-UHFFFAOYSA-N
Safety
- WGK Germany
- 3
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 676624
- Product name
- 5-Methoxy-3-pyridineboronic acid pinacol ester
- Purity
- 97%
- Packaging
- 1g
- Price
- $79.6
- Updated
- 2023/01/07
- Product number
- 676624
- Product name
- 5-Methoxy-3-pyridineboronic acid pinacol ester
- Purity
- 97%
- Packaging
- 5g
- Price
- $352
- Updated
- 2023/01/07
- Product number
- M2994
- Product name
- 3-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $186
- Updated
- 2025/07/31
- Product number
- BOR0001297
- Product name
- 3-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $247.8
- Updated
- 2021/12/16
- Product number
- 007384
- Product name
- 3-Methoxy-5-pyridineboronic acidpinacol ester
- Purity
- 98%
- Packaging
- 5g
- Price
- $258
- Updated
- 2021/12/16
3-Methoxypyridine-5-boronic acid pinacol ester Chemical Properties,Usage,Production
Uses
5-Methoxy-3-pyridineboronic acid pinacol ester can be used:
- To synthesize anthracene based bis-pyridine ligand (L), which is employed in the preparation of fluorescent M2L4 type capsules (M= Pt, Zn, Pd, Cu, Ni, Co, and Mn).
- As a starting material in the synthesis of pyridylmethyl?pyridine derivatives as potent 11β-hydroxylase (CPY11B1) inhibitors.
Uses
3-Methoxypyridine-5-boronic acid pinacol ester is for use in Suzuki-Miyaura aryl-aryl cross-coupling.
Synthesis
50720-12-2
73183-34-3
445264-60-8
The reaction was carried out in anhydrous toluene (25 mL) with 3-bromo-5-methoxypyridine (2 g, 10.63 mmol), bis(pinacolato)diboron (4.05 g, 15.98 mmol) and potassium acetate (4.78 g, 42.55 mmol). The reaction system was first degassed with nitrogen. Under nitrogen protection, Pd(dppf)Cl2-DCM (0.87 g, 0.10 mmol) was added to the reaction system and the reaction mixture was subsequently heated to reflux for 2 hours. The reaction process was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was cooled to room temperature (25 °C) and filtered through a Celite pad. The filtrate was diluted with ethyl acetate (100 mL), washed sequentially with water and brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by column chromatography on silica gel (100-200 mesh), and the eluent was a hexane solution of 10% ethyl acetate, and 2.6 g of the target product, 5-methoxy-3-pyridinopinacol borate, was finally obtained. The product was analyzed by LC-MS and the molecular weight was 236 (M+H).
References
[1] Patent: WO2009/74812, 2009, A1. Location in patent: Page/Page column 68
[2] Patent: WO2014/186035, 2014, A1. Location in patent: Page/Page column 156
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 23, p. 10479 - 10497
[4] Patent: CN106674200, 2017, A. Location in patent: Paragraph 0112; 0113
3-Methoxypyridine-5-boronic acid pinacol ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Methoxypyridine-5-boronic acid pinacol ester manufacturers
- Product
- 3-Methoxypyridine-5-boronic acid pinacol ester 445264-60-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-12
- Product
- 3-Methoxypyridine-5-boronic acid pinacol ester 445264-60-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97-99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-19