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N-Butyl-1-deoxygalactonojirimycin

Product Name
N-Butyl-1-deoxygalactonojirimycin
CAS No.
141206-42-0
Chemical Name
N-Butyl-1-deoxygalactonojirimycin
Synonyms
OGT-923);ACT-434964;Lucerastat;N-Butyl-1-deoxygalactonojirimycin;Migalastat Impurity 1 (Lucerastat);Lucerastat (N-Butyldeoxygalactonojirimycin;(2R,3S,4R,5S)-1-Butyl-2-(hydroxyMethyl)-3,4,5-piperidinetriol;3,4,5-Piperidinetriol, 1-butyl-2-(hydroxymethyl)-, (2R,3S,4R,5S)-;(2R,3S,4R,5S)-1-(But-1-yl)-2-(hydroxymethyl)piperidine-3,4,5-triol;N-(But-1-yl)deoxygalactonojirimycin, (2R,3S,4R,5S)-1-(But-1-yl)-2-(hydroxymethyl)-3,4,5-trihydroxypiperidine
CBNumber
CB21232075
Molecular Formula
C10H21NO4
Formula Weight
219.28
MOL File
141206-42-0.mol
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N-Butyl-1-deoxygalactonojirimycin Property

Melting point:
123-124°C
Boiling point:
394.7±42.0 °C(Predicted)
Density 
1.234±0.06 g/cm3(Predicted)
storage temp. 
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility 
DMF: 20 mg/mL; DMSO: 30 mg/mL; Ethanol: 5 mg/mL; PBS (pH 7.2): 10 mg/mL
form 
A crystalline solid
pka
13.72±0.70(Predicted)
color 
White to yellow
Stability:
Hygroscopic
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19520
Product name
N-(n-Butyl)deoxygalactonojirimycin
Purity
≥95%
Packaging
500μg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
19520
Product name
N-(n-Butyl)deoxygalactonojirimycin
Purity
≥95%
Packaging
1mg
Price
$78
Updated
2024/03/01
Cayman Chemical
Product number
19520
Product name
N-(n-Butyl)deoxygalactonojirimycin
Purity
≥95%
Packaging
5mg
Price
$193
Updated
2024/03/01
TRC
Product number
B690500
Product name
N-(n-Butyl)deoxygalactonojirimycin
Packaging
25mg
Price
$725
Updated
2021/12/16
Biosynth Carbosynth
Product number
MB04497
Product name
N-Butyldeoxygalactonojirimycin
Packaging
25mg
Price
$1100
Updated
2021/12/16
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N-Butyl-1-deoxygalactonojirimycin Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid

Uses

An extremely potent and selective a-D-galactosidase inhibitor. A selective inhibitior of GlcCer synthesis.

in vivo

Lucerastat (1200 mg/kg/day food admix), a GCS inhibitor, reduces Gb3 in the absence of residual-GalA activity[2].

Animal Model:Fabry mice (Gla-/0 and Gla-/-, n = 5 or 6 for each gender)[2].
Dosage:1200 mg/kg/day food admix.
Administration:Food admix for 20 weeks.
Result:Reduced lipid storage in two major organs affected by FD: mean Gb3 in the kidneys (-33%, p<0.01). and α-galactose- terminated glycosphingolipids in the dorsal root ganglia (-48%, p<0.05). In the liver of the Fabry mice, mean glucosylceramide (GlcCer (24:0)) was reduced (-59%, p<0.001) in addition to Gb3 (24:1) (-37%, p<0.05) demonstrating substrate reduction through GCS inhibition.

N-Butyl-1-deoxygalactonojirimycin Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Butyl-1-deoxygalactonojirimycin Suppliers

Canada 1 China 36 India 1 United Kingdom 3 United States 8 Global 49
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
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inquiry@bocsci.com
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United States
ProdList
19552
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58
TargetMol Chemicals Inc.
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+17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
19961
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58
Aladdin Scientific
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Email
tp@aladdinsci.com
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United States
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52923
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58
TargetMol Chemicals Inc.
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+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
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58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
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65
Cayman Chemical Company
Tel
--
Fax
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Email
cayman@caymanchem.com
Country
United States
ProdList
6213
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MedChemExpress
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sales@medchemexpress.com
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United States
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SynQuest Laboratories, Inc.
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Email
info@synquestlabs.com
Country
United States
ProdList
6871
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141206-42-0, N-Butyl-1-deoxygalactonojirimycinRelated Search:

Nucleoside N-Butyl-1-deoxygalactonojirimycin trans-3,4-Dihydroxypiperidine (S)-3-ISOPROPYLAMINO-1,2-PROPANEDIOL (R)-3-Hydroxypiperidine hydrocloride cis-3,4-Dihydroxypiperidine N-(n-Nonyl)deoxygalactonojirimycin 2,2'-(Butylimino)diethanol

  • N-Butyl-1-deoxygalactonojirimycin
  • (2R,3S,4R,5S)-1-(But-1-yl)-2-(hydroxymethyl)piperidine-3,4,5-triol
  • N-(But-1-yl)deoxygalactonojirimycin, (2R,3S,4R,5S)-1-(But-1-yl)-2-(hydroxymethyl)-3,4,5-trihydroxypiperidine
  • (2R,3S,4R,5S)-1-Butyl-2-(hydroxyMethyl)-3,4,5-piperidinetriol
  • Lucerastat
  • ACT-434964
  • Lucerastat (N-Butyldeoxygalactonojirimycin
  • OGT-923)
  • 3,4,5-Piperidinetriol, 1-butyl-2-(hydroxymethyl)-, (2R,3S,4R,5S)-
  • Migalastat Impurity 1 (Lucerastat)
  • 141206-42-0
  • Glycosidase Inhibitors
  • Inhibitors