2-[[2-(4-hydroxyphenyl)acetyl]amino]acetic acid
- Product Name
- 2-[[2-(4-hydroxyphenyl)acetyl]amino]acetic acid
- CAS No.
- 28116-23-6
- Chemical Name
- 2-[[2-(4-hydroxyphenyl)acetyl]amino]acetic acid
- Synonyms
- Hydroxyphenylacetylglycine;CPPDWYIPKSSNNM-UHFFFAOYSA-N;p-Hydroxyphenylacetylglycine;4-Hydroxyphenylacetyl glycine;N-[2-(4-Hydroxyphenyl)acetyl]glycine;Glycine, N-[2-(4-hydroxyphenyl)acetyl]-;Hydroxyphenylacetylglycine, 10 mM in DMSO;N-[2-(4-Hydroxyphenyl)acetyl]glycine;2-[2-(4-hydroxyphenyl)acetamido]acetic acid;2-[[2-(4-hydroxyphenyl)acetyl]amino]acetic acid
- CBNumber
- CB21236013
- Molecular Formula
- C10H11NO4
- Formula Weight
- 209.2
- MOL File
- 28116-23-6.mol
2-[[2-(4-hydroxyphenyl)acetyl]amino]acetic acid Property
- Melting point:
- >144°C (dec.)
- Boiling point:
- 563.0±40.0 °C(Predicted)
- Density
- 1.356±0.06 g/cm3(Predicted)
- storage temp.
- Hygroscopic, Refrigerator, under inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 3.52±0.10(Predicted)
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
- Major Application
- clinical testing
- InChI
- 1S/C10H11NO4/c12-8-3-1-7(2-4-8)5-9(13)11-6-10(14)15/h1-4,12H,5-6H2,(H,11,13)(H,14,15)
- InChIKey
- CPPDWYIPKSSNNM-UHFFFAOYSA-N
- SMILES
- OC(CNC(CC1=CC=C(O)C=C1)=O)=O
Safety
- WGK Germany
- WGK 3
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Eye Irrit. 2
Skin Irrit. 2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 461862
- Product name
- p-Hydroxyphenylacetylglycine
- Packaging
- 250mg
- Price
- $460
- Updated
- 2021/12/16
- Product number
- H950980
- Product name
- p-Hydroxyphenylacetylglycine
- Packaging
- 2.5g
- Price
- $1390
- Updated
- 2021/12/16
- Product number
- CHM0107745
- Product name
- 2-[2-(4-HYDROXYPHENYL)ACETAMIDO]ACETIC ACID
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $1473.14
- Updated
- 2021/12/16
- Product number
- 2757CC
- Product name
- 4-Hydroxyphenylacetylglycine
- Packaging
- 5g
- Price
- $1829
- Updated
- 2021/12/16
- Product number
- CHM0107745
- Product name
- 2-[2-(4-HYDROXYPHENYL)ACETAMIDO]ACETIC ACID
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1928.08
- Updated
- 2021/12/16
2-[[2-(4-hydroxyphenyl)acetyl]amino]acetic acid Chemical Properties,Usage,Production
Uses
p-Hydroxyphenylacetylglycine is derived from the metabolism of L-DOPA (D533751), a dopamine precursor that induces dyskinesia in Parkinson’s disease patients. p-Hydroxyphenylacetylglycine is also used as a reagent to synthesize novel piperazine salts that have antimicrobial activity against Escherichia coli and Bacillus subtilis.
Definition
ChEBI: Phenylacetylglycine hydroxylated at the phenyl C-4 position.
Biological Activity
Hydroxyphenylacetylglycine is an acylglycine. Acylglycines are normally minor metabolites of fatty acids. However, the excretion of certain acylglycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme th at catalyzes the chemical reaction: acyl-CoA + glycine ↔ CoA + N-acylglycine. Hydroxyphenylacetylglycine is an endogenous human metabolite. It can be originated from the metabolism of tyramine, itself is a monoamine compound derived from the amino acid tyrosine. Hydroxyphenylacetylglycine can also be derived from the metabolism of 3,4-dihydroxyphenylalanine (L-DOPA). In the metabolism of tyrosine, this compound is involved in the reaction Hydroxyphenylacetyl-CoA + Glycine ↔ Hydroxyphenylacetylglycine + CoA, catalyzed by acyltransferase enzymes (EC 2.3.1.-). Hydroxyphenylacetylglycine has been identified in human biofluids.
IC 50
Human Endogenous Metabolite
2-[[2-(4-hydroxyphenyl)acetyl]amino]acetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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