1-methyl-6-oxo-pyridine-3-carboxamide
- Product Name
- 1-methyl-6-oxo-pyridine-3-carboxamide
- CAS No.
- 701-44-0
- Chemical Name
- 1-methyl-6-oxo-pyridine-3-carboxamide
- Synonyms
- 2-Py;Nudifloramide;N-methyl-6-pyridone-3-carboxamide;N'-methyl-2-pyridone-5-carboxamide;N1-Methyl-2-pyridone-5-carboxamide;1-methyl-6-oxo-pyridine-3-carboxamide;1-Methyl-6-oxo-1,6-dihydronicotinamide;Nicotinamide Impurity 6（Nedifloramide）;N-Methyl-2-pyridone-5-carboxamide;1-Methyl 6-oxo-1,6-dihydro-3-pyridinecarboxamide
- CBNumber
- CB21236109
- Molecular Formula
- C7H8N2O2
- Formula Weight
- 152.15
- MOL File
- 701-44-0.mol
1-methyl-6-oxo-pyridine-3-carboxamide Property
- Melting point:
- 202-207°C (dec.)
- Boiling point:
- 396.7±42.0 °C(Predicted)
- Density
- 1.300±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated)
- form
- Solid
- pka
- 14.46±0.20(Predicted)
- color
- White to Light Brown
- InChI
- 1S/C7H8N2O2/c1-9-4-5(7(8)11)2-3-6(9)10/h2-4H,1H3,(H2,8,11)
- InChIKey
- JLQSXXWTCJPCBC-UHFFFAOYSA-N
- SMILES
- [n]1([c](ccc(c1)C(=O)N)=O)C
Safety
- WGK Germany
- WGK 3
- Storage Class
- 11 - Combustible Solids
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SMB01345
- Product name
- N-Methyl-2-pyridone-5-carboxamide
- Packaging
- 50MG
- Price
- $66.3
- Updated
- 2026/03/19
- Product number
- SMB01345
- Product name
- N-Methyl-2-pyridone-5-carboxamide
- Packaging
- 250MG
- Price
- $238
- Updated
- 2026/03/19
- Product number
- M3731
- Product name
- Nudifloramide
- Packaging
- 50MG
- Price
- $75
- Updated
- 2026/03/19
- Product number
- 20507
- Product name
- Nudifloramide
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 20507
- Product name
- Nudifloramide
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $161
- Updated
- 2024/03/01
1-methyl-6-oxo-pyridine-3-carboxamide Chemical Properties,Usage,Production
Description
Nudifloramide, known more commonly as N-methyl-2-pyridone-5-carboxamide (2-Py), is a metabolite of niacin via nicotinamide. It can be measured in serum and urine as part of metabolomic studies of niacin or nicotinamide intake and usage. Circulating levels of nudifloramide can be elevated and associated with toxic effects in patients receiving supplemental nicotinamide.
Chemical Properties
Light Brown Solid
Uses
Nudifloramide is a metabolite of Niacin (or Nicorinic acid).
Definition
ChEBI: A pyridone that is 2-pyridone substituted with a carboxamide group at C-5 and a methyl group at N-1.
Synthesis
10561-91-8
701-44-0
The general procedure for the synthesis of 1-methyl-6-oxo-pyridine-3-carboxamide from ethyl 1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate was as follows: ethyl 1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate (0.2 g, 1.01 mmol) was dissolved in methanol-ammonia solution (10.0 mL), and the reaction was stirred for 16 hours at 70 °C. The reaction process was monitored by thin layer chromatography (TLC) [Expanding agent: 5% methanol-dichloromethane (v/v)]. After completion of the reaction, the reaction mixture was concentrated under reduced pressure to give the crude product. The crude product was ground with ether (10.0 mL) and filtered through a Büchner funnel and dried under vacuum to afford 1-methyl-6-oxopyridine-3-carboxamide as a white solid (15.0 g, 82% yield). The structure of the product was confirmed by 1H NMR (DMSO-d6, 400 MHz) and mass spectrometry (ESI): 1H NMR δ 3.44 (s, 3H), 6.35 (d, J = 9.2 Hz, 1H), 7.18 (bs, 1H), 7.65 (bs, 1H), 7.82 (dd, J = 2.4 Hz, J = 9.6 Hz, 1H), 8.66 (dd, J = 2.4 Hz, 1H); MS (ESI) m/z 153.0 (M + H)+; HPLC purity (254 nm) was 99%.
IC 50
Human Endogenous Metabolite
References
[1] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 5, p. 922 - 925
[2] Biochemical Journal, 1948, vol. 43, p. 423,425
1-methyl-6-oxo-pyridine-3-carboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
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