A 10

Product Name: A 10
CAS No.: 91531-30-5
Chemical Name: A 10
Synonyms: A 10;NSC-648539;Antineoplaston A10(b);Antineoplaston A10 NSC 620261;Antineoplaston A10, 10 mM in DMSO;N-(2,6-Dioxopiperidin-3-yl)benzeneacetamide;(S)-N-(2,6-Dioxopiperidin-3-yl)-2-phenylacetamide;Benzeneacetamide, N-[(3S)-2,6-dioxo-3-piperidinyl]-;Inhibitor,Antineoplaston A10,inhibit,Ras,Endogenous Metabolite,Antineoplaston A-10,Antineoplaston A 10,Apoptosis
CBNumber: CB21244340
Molecular Formula: C13H14N2O3
Formula Weight: 246.26
MOL File: 91531-30-5.mol

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A 10 Property

Boiling point:: 571.2±49.0 °C(Predicted)
Density: 1.27±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO: 250 mg/mL (1015.19 mM)
pka: 10.79±0.40(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0095862
Product name: AntineoplastonA10
Purity: 98.58%
Packaging: 5mg
Price: $135
Updated: 2021/12/16

ChemScene

Product number: CS-0095862
Product name: AntineoplastonA10
Purity: 98.58%
Packaging: 10mg
Price: $225
Updated: 2021/12/16

ChemScene

Product number: CS-0095862
Product name: AntineoplastonA10
Purity: 98.58%
Packaging: 50mg
Price: $765
Updated: 2021/12/16

ChemScene

Product number: CS-0095862
Product name: AntineoplastonA10
Purity: 98.58%
Packaging: 100mg
Price: $1350
Updated: 2021/12/16

Ambeed

Product number: A1149313
Product name: AntineoplastonA10
Purity: 98%
Packaging: 5mg
Price: $147
Updated: 2021/12/16

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A 10 Chemical Properties,Usage,Production

Uses

Antineoplaston A10 is an antineoplaston that inhibits the growth of human hepatoma cells by inducing apoptosis. Antineoplaston A10 can be used in the study of liver cancer and breast cancer[1][2].

in vivo

Antineoplaston A10 (0-600 mg/kg; p.o.; 6 days per week for 5 weeks) dose-dependently inhibits the growth of HepG2 and HLE cells in mice and dose-dependently increases the incidence of apoptotic cells in xenograft mice^[1].

Animal Model:	Balb/c athymic (nu+/nu+) female mice with hepatocellular carcinoma xenografts^[1].
Dosage:	0, 150, 300 and 600 mg/kg
Administration:	Oral gavage (p.o.) 6 days per week for 5 weeks
Result:	Reduced the expression of bcl-2 in the cytoplasm, and the bcl-2 positive cell rates decreased to 82.9, 69.4 and 56.3%, respectively. Increased the expression of p53 in the nucleus, and the p53 positive cell rates increased to 20.6%, 36.2 and 60.5%, respectively.

References

[1] Qu XJ, et al. Induction of apoptosis in human hepatocellular carcinoma cells by synthetic antineoplaston A10. Anticancer Res. 2007 Jul-Aug;27(4B):2427-31. PMID:17695534
[2] Tsuda, et al. "Inhibitory effect of antineoplaston A-10 on breast cancer transplanted to athymic mice and human hepatocellular carcinoma cell lines." The Kurume Medical Journal 37.2 (1990): 97-104. DOI:10.2739/kurumemedj.37.97

A 10 Preparation Products And Raw materials

Raw materials

Preparation Products

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A 10 Suppliers

China 52 United States 5 Global 57

AdooQ Bioscience CHINA

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Fax: QQ:3008007432
Email: 3008007409@qq.com
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Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
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Beijing Solarbio Science & Tecnology Co., Ltd.

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Email: psaitong@jm-bio.com
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Fan De(Beijing) Biotechnology Co., Ltd.

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Jiangsu aikang biomedical research and development co., LTD

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Email: qzhang@aikonchem.com
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Henan Alpha Chemical Co., Ltd.

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InvivoChem

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Career Henan Chemica Co

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91531-30-5, A 10Related Search:

SW 837 NA SUPB15 NA Nb2-11 NA SF126 NA KOPN-8 4-Morpholineethanesulfonic acid H-ARG-LEU-OH ACETATE SALT NA NA HOP-62 human lung cancer cells NA NCI-H660 human small cell carcinoma of the prostate OCI-AML2 Human Acute Myeloid Leukemia Cells NA

A 10

N-(2,6-Dioxopiperidin-3-yl)benzeneacetamide

Antineoplaston A10 NSC 620261

NSC-648539

Antineoplaston A10(b)

Benzeneacetamide, N-[(3S)-2,6-dioxo-3-piperidinyl]-

(S)-N-(2,6-Dioxopiperidin-3-yl)-2-phenylacetamide

Inhibitor,Antineoplaston A10,inhibit,Ras,Endogenous Metabolite,Antineoplaston A-10,Antineoplaston A 10,Apoptosis

Antineoplaston A10, 10 mM in DMSO

91531-30-5