(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one
- Product Name
- (3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one
- CAS No.
- 187523-35-9
- Chemical Name
- (3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one
- Synonyms
- MaxiPost;FLINDOKALNER;BMS-204352 (BMS 204352;Flindokalner BMS-204352;Flindokalner, 10 mM in DMSO;(S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-6-(trifluoromethyl)indolin-2-one;(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one;(3S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-Indol-2-one;2H-Indol-2-one, 3-(5-chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-, (3S)-;inhibit,KcsA,Flindokalner,neuronal,ventricular,effects,BMS204352,anxiolytic,subtype,Potassium Channel,Inhibitor,BMS 204352,myocytes,current
- CBNumber
- CB21253977
- Molecular Formula
- C16H10ClF4NO2
- Formula Weight
- 359.7
- MOL File
- 187523-35-9.mol
(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one Property
- Boiling point:
- 436.9±45.0 °C(Predicted)
- Density
- 1.50±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble to 100 mM in DMSO and to 100 mM in ethanol
- form
- Powder
- pka
- 10.43±0.40(Predicted)
- color
- White to off-white
- InChI
- InChI=1S/C16H10ClF4NO2/c1-24-13-5-3-9(17)7-11(13)15(18)10-4-2-8(16(19,20)21)6-12(10)22-14(15)23/h2-7H,1H3,(H,22,23)/t15-/m0/s1
- InChIKey
- ULYONBAOIMCNEH-HNNXBMFYSA-N
- SMILES
- N1C2=C(C=CC(C(F)(F)F)=C2)[C@@](C2=CC(Cl)=CC=C2OC)(F)C1=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1313
- Product name
- BMS 204352
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $150
- Updated
- 2025/07/31
- Product number
- SML1313
- Product name
- BMS 204352
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $742
- Updated
- 2025/07/31
- Product number
- 29378
- Product name
- BMS 204352
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 29378
- Product name
- BMS 204352
- Packaging
- 10mg
- Price
- $266
- Updated
- 2024/03/01
- Product number
- 29378
- Product name
- BMS 204352
- Packaging
- 5mg
- Price
- $142
- Updated
- 2024/03/01
(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one Chemical Properties,Usage,Production
Uses
Neuroprotectant (opener of large conductance, calcium-activated (maxi-K) K+channels.
Biological Activity
BMS 204352 (MaxiPost [(3S)-(+)-(5-chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-2H-indole-2-one)] is used to tre at ischemic stroke. It also acts as an activator of KNCQ4 (KQT-like subfamily, member 4) and KCNQ5 (KQT-like subfamily, member 5) with equal potency.', 'BMS 204352 is a potassium channel modulator. Originally developed as a potent opener of large-conductance, calcium-activated (Maxi-K, KCa1.1, BK) potassium channels, BMS 204352 also acts as a positive modulator at Kv7 (KCNQ) channels.
in vivo
Flindokalner (BMS-204352) (3-30 mg/kg; i.p.) induces a dose-dependent anxiolytic effect[1].
In shock-based conditioned model of anxiety in male Wistar rats, Flindokalner (3-60 mg/kg; i.p.) engenderes an anxiolytic profile[1].
| Animal Model: | Female NMRI or male C57 mice (20-25 g) (Anxiolytic Models)[1] |
| Dosage: | i.p. |
| Administration: | 3, 10, 30 mg/kg |
| Result: | Significantly and dose dependently increased time spent in the open areas, reduced latency to enter an open area, and increased the number of entries in to the open areas in Zero Maze. |
storage
Store at +4°C
(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
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