ChemicalBook > CAS DataBase List > (3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one

(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one

Product Name
(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one
CAS No.
187523-35-9
Chemical Name
(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one
Synonyms
MaxiPost;FLINDOKALNER;BMS-204352 (BMS 204352;Flindokalner BMS-204352;Flindokalner, 10 mM in DMSO;(S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-6-(trifluoromethyl)indolin-2-one;(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one;(3S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-Indol-2-one;2H-Indol-2-one, 3-(5-chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-, (3S)-;inhibit,KcsA,Flindokalner,neuronal,ventricular,effects,BMS204352,anxiolytic,subtype,Potassium Channel,Inhibitor,BMS 204352,myocytes,current
CBNumber
CB21253977
Molecular Formula
C16H10ClF4NO2
Formula Weight
359.7
MOL File
187523-35-9.mol
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(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one Property

Boiling point:
436.9±45.0 °C(Predicted)
Density 
1.50±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble to 100 mM in DMSO and to 100 mM in ethanol
form 
Powder
pka
10.43±0.40(Predicted)
color 
White to off-white
InChI
InChI=1S/C16H10ClF4NO2/c1-24-13-5-3-9(17)7-11(13)15(18)10-4-2-8(16(19,20)21)6-12(10)22-14(15)23/h2-7H,1H3,(H,22,23)/t15-/m0/s1
InChIKey
ULYONBAOIMCNEH-HNNXBMFYSA-N
SMILES
N1C2=C(C=CC(C(F)(F)F)=C2)[C@@](C2=CC(Cl)=CC=C2OC)(F)C1=O
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1313
Product name
BMS 204352
Purity
≥98% (HPLC)
Packaging
5mg
Price
$150
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1313
Product name
BMS 204352
Purity
≥98% (HPLC)
Packaging
25mg
Price
$742
Updated
2025/07/31
Cayman Chemical
Product number
29378
Product name
BMS 204352
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
29378
Product name
BMS 204352
Packaging
10mg
Price
$266
Updated
2024/03/01
Cayman Chemical
Product number
29378
Product name
BMS 204352
Packaging
5mg
Price
$142
Updated
2024/03/01
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(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one Chemical Properties,Usage,Production

Uses

Neuroprotectant (opener of large conductance, calcium-activated (maxi-K) K+channels.

Biological Activity

BMS 204352 (MaxiPost [(3S)-(+)-(5-chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-2H-indole-2-one)] is used to tre at ischemic stroke. It also acts as an activator of KNCQ4 (KQT-like subfamily, member 4) and KCNQ5 (KQT-like subfamily, member 5) with equal potency.', 'BMS 204352 is a potassium channel modulator. Originally developed as a potent opener of large-conductance, calcium-activated (Maxi-K, KCa1.1, BK) potassium channels, BMS 204352 also acts as a positive modulator at Kv7 (KCNQ) channels.

in vivo

Flindokalner (BMS-204352) (3-30 mg/kg; i.p.) induces a dose-dependent anxiolytic effect[1].
In shock-based conditioned model of anxiety in male Wistar rats, Flindokalner (3-60 mg/kg; i.p.) engenderes an anxiolytic profile[1].

Animal Model:Female NMRI or male C57 mice (20-25 g) (Anxiolytic Models)[1]
Dosage:i.p.
Administration:3, 10, 30 mg/kg
Result:Significantly and dose dependently increased time spent in the open areas, reduced latency to enter an open area, and increased the number of entries in to the open areas in Zero Maze.

storage

Store at +4°C

(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

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(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one Suppliers

China 35 The Netherlands 1 United Kingdom 1 United States 7 Global 44
Axon Medchem BV
Tel
--
Fax
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Email
info@axonmedchem.com
Country
The Netherlands
ProdList
477
Advantage
30

187523-35-9, (3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-oneRelated Search:


  • (3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one
  • FLINDOKALNER
  • MaxiPost
  • (3S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-Indol-2-one
  • BMS-204352 (BMS 204352
  • 2H-Indol-2-one, 3-(5-chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-, (3S)-
  • Flindokalner BMS-204352
  • inhibit,KcsA,Flindokalner,neuronal,ventricular,effects,BMS204352,anxiolytic,subtype,Potassium Channel,Inhibitor,BMS 204352,myocytes,current
  • (S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-6-(trifluoromethyl)indolin-2-one
  • Flindokalner, 10 mM in DMSO
  • 187523-35-9
  • C16H10ClF4NO2