(3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol

ChemicalBook > CAS DataBase List > (3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol

(3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol

Product Name: (3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol
CAS No.: 156722-18-8
Chemical Name: (3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol
Synonyms: CS-906;PST2238;17-triol;AC1L4BGU;Rostafuroxin;CHEMBL2068971;SureCN1716210;UNII-P848LCX62B;PST 2238, >=98%;PST2238,Rostafuroxin
CBNumber: CB21253997
Molecular Formula: C23H34O4
Formula Weight: 374.51
MOL File: 156722-18-8.mol

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(3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol Property

Boiling point:: 451.3±45.0 °C(Predicted)
Density: 1.226±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥12.05 mg/mL in DMSO
form: solid
pka: 14.02±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21282
Product name: Rostafuroxin
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 21282
Product name: Rostafuroxin
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 21282
Product name: Rostafuroxin
Purity: ≥98%
Packaging: 10mg
Price: $169
Updated: 2024/03/01

Cayman Chemical

Product number: 21282
Product name: Rostafuroxin
Purity: ≥98%
Packaging: 25mg
Price: $381
Updated: 2024/03/01

Tocris

Product number: 5315
Product name: Rostafuroxin
Purity: ≥98%(HPLC)
Packaging: 10
Price: $210
Updated: 2021/12/16

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(3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol Chemical Properties,Usage,Production

Description

Rostafuroxin potently inhibits binding of endogenous ouabain to the Na⁺/K⁺ ATPase (IC₅₀ = 1.7 μM) through the Src-epidermal growth factor receptor (EGFR)-dependent signaling pathway. This blocks the ouabain-dependent increase in Na⁺/K⁺ ATPase activity. In cultured renal cells where the Na⁺/K⁺ ATPase is upregulated or has increased activity, rostafuroxin normalizes mRNA levels and Na⁺/K⁺ ATPase activity. At very low doses (1 and 10 μg/kg for 5-6 weeks) in Milan-hypertensive rats, it decreased the development of hypertension. In a Phase II clinical study, rostafuroxin did not reduce blood pressure in human patients at doses of 0.05-5.0 mg/d.

Uses

(3β,5β,14β)-21,23-Epoxy-24-Norchola-20,22-diene-3,14,17-triol is used as a receptor blocker in the treatment of hypertension.

in vitro

at molecular level, in the kidney, rostafuroxin antagonizes eo by triggering of the src-epidermal growth factor receptor (egfr)-dependent signaling pathway leading to renal na+-k+ pump, and erk tyrosine phosphorylation and activation. in the vasculature, it normalizes the increased myogenic tone caused by nanomolar ouabain [1].

in vivo

rostafuroxin reduces blood pressure without affecting heart rate, and restores the normal activity of the renal na+-k+-atpase in mhs rats when orally treated at doses from 1 to 100 μg/kg/day. similarly, nua rats have their blood pressure normalized by rostafuroxin [1].

IC 50

2 μm for na+-k+-atpase

storage

Store at +4°C

References

[1] ferrari p, ferrandi m, valentini g, bianchi g. rostafuroxin: an ouabain antagonist that corrects renal and vascular na+-k+-atpase alterations in ouabain and adducin-dependent hypertension. am j physiol regul integr comp physiol. 2006 mar;290(3):r529-35.

(3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol Preparation Products And Raw materials

Raw materials

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View Lastest Price from (3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Rostafuroxin 156722-18-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Rostafuroxin 156722-18-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

156722-18-8, (3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triolRelated Search:

(3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol

Rostafuroxin

PST2238

(3β,5β,14β)-21,23-Epoxy-24-Norchola-20,22-diene-3,14,17-triol

Rostafuroxin (PST-2238)

(3beta,5beta,14beta)-21,23-Epoxy-24-norchola-20,22-diene-3,14,17-triol

Rostafuroxin PST2284

(3beta,5beta,14beta)-21,23-Epoxy-24-norchola-20,22-diene-3,14,17-triol Rostafuroxin (PST 2238)

CS-906

17-β-(3-furyl)-5-β-androstane-3-β, 14-β, 17-α-triol

17-(3-Furyl)-5beta-androstane-3

17-triol

AC1L4BGU

CHEMBL2068971

PST 2238; PST-2238; AC1L4BGU; SURECN1716210; UNII-P848LCX62B; 17-(3-FURYL)-5BETA-ANDROSTANE-3;14;17-TRIOL; CHEMBL2068971; 156722-18-8

SureCN1716210

UNII-P848LCX62B

Rostafuroxin (3beta,5beta,14beta)-21,23-Epoxy-24-norchola-20,22-diene-3,14,17-triol

PST 2238, >=98%

PST2238,Rostafuroxin

24-Norchola-20,22-diene-3,14,17-triol, 21,23-epoxy-, (3β,5β,14β)-

24-Norchola-20,22-diene-3,14,17-triol,21,23-epoxy-, (3b,5b,14b)-

Rostafuroxin,ATP1A1,RSV,PST-2238,Respiratory syncytial virus,Na+/K+ ATPase,phosphorylation,inhibit,PST2238,Tyr845,Sodium potassium pump,EGFR,antihypertensive,RSV-GFP,Inhibitor,digitoxigenin,Ouabain

(3β,5β,14β)-21,23-Epoxy-24-Norchola-20,22-diene-3,14,17-triol

(3S,5R,8R,9S,10S,13S,14S,17S)-17-(Furan-3-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol

(1S,3aS,3bR,5aR,7S,9aS,9bS,11aS)-1-(furan-3-yl)-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthrene-1,3a,7-triol

156722-18-8

Inhibitors