2,2,3-tribromopropanal
- Product Name
- 2,2,3-tribromopropanal
- CAS No.
- 26944-17-2
- Chemical Name
- 2,2,3-tribromopropanal
- Synonyms
- Propanal, 2,2,3-tribromo-;2,2,3-Tribromopropionaldehyde;2,2,3-trisbromopropionaldehyde
- CBNumber
- CB21256105
- Molecular Formula
- C3H3Br3O
- Formula Weight
- 294.77
- MOL File
- 26944-17-2.mol
2,2,3-tribromopropanal Property
- Boiling point:
- 214℃
- Density
- 2.563
- Flash point:
- 85℃
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- EPA Substance Registry System
- Propanal, 2,2,3-tribromo- (26944-17-2)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- T772700
- Product name
- 2,2,3-Tribromopropanal
- Packaging
- 1g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- 098289
- Product name
- 2,2,3-Tribromopropanal
- Purity
- 95+%
- Packaging
- 1g
- Price
- $153
- Updated
- 2021/12/16
- Product number
- 2470AB
- Product name
- 2,2,3-Tribromopropanal
- Packaging
- 10g
- Price
- $164
- Updated
- 2021/12/16
- Product number
- 239010
- Product name
- 2,2,3-Tribromopropanal
- Purity
- 95%
- Packaging
- 250mg
- Price
- $19
- Updated
- 2021/12/16
- Product number
- 2470AB
- Product name
- 2,2,3-Tribromopropanal
- Packaging
- 1g
- Price
- $71
- Updated
- 2021/12/16
2,2,3-tribromopropanal Chemical Properties,Usage,Production
Uses
2,2,3-Tribromopropanal is a versatile reagent that was used for the first time in the 1950s. It is used as a reagent in the Skraup-type synthesis of 3-bromoquinolin-6-ols. 2,2,3-Tribromopropanal is also used in the preparation of quinolinyloxyacetamides, a novel class of tubulin polymerization inhibitors with fungicidal activity.
Synthesis
107-02-8
26944-17-2
Example 4 Preparation of 2,2,3-tribromopropionaldehyde: Bromine (1.79 mol) was slowly added dropwise to a solution of acrolein (100.0 g, 1.78 mol) dissolved in dichloromethane (150 ml) over a period of 3 hours. The reaction temperature needs to be controlled to be maintained between 40°C and 50°C during the dropwise addition. Subsequently, the reaction mixture was heated to 70 °C and bromine (285.8 g, 1.78 mol) was added slowly dropwise over a period of 4 hours. It was necessary to ensure that the temperature of the solution was maintained between 70 °C and 80 °C during the dropwise addition. Upon completion of the reaction, the mixture was cooled to room temperature and the volatile components were removed by evaporation to afford 2,2,3-tribromopropanal in 99.4% yield.
References
[1] Patent: US4489098, 1984, A
[2] Synlett, 2014, vol. 25, # 6, p. 858 - 862
[3] ChemMedChem, 2018, vol. 13, # 12, p. 1160 - 1164
2,2,3-tribromopropanal Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,2,3-tribromopropanal manufacturers
- Product
- 2,2,3-Tribromopropanal 26944-17-2
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 95%-99%
- Supply Ability
- 1kg; 100kg; 1000kg
- Release date
- 2019-12-24