4-[(2R,5S,6E)-2-hydroxy-5,7-dimethyl-4-oxo-nona-6,8-dienyl]piperidine- 2,6-dione
- Product Name
- 4-[(2R,5S,6E)-2-hydroxy-5,7-dimethyl-4-oxo-nona-6,8-dienyl]piperidine- 2,6-dione
- CAS No.
- 738-72-7
- Chemical Name
- 4-[(2R,5S,6E)-2-hydroxy-5,7-dimethyl-4-oxo-nona-6,8-dienyl]piperidine- 2,6-dione
- Synonyms
- S-632A1;Protomycin;Streptimidon;streptimidone;Streptoimidone;4-[(2R,5S,6E)-2-Hydroxy-5,7-dimethyl-4-oxo-6,8-nonadienyl]-2,6-piperidinedione;4-[(2R,5S,6E)-2-hydroxy-5,7-dimethyl-4-oxo-nona-6,8-dienyl]piperidine- 2,6-dione;2,6-Piperidinedione,4-[(2R,5S,6E)-2-hydroxy- 5,7-dimethyl-4-oxo-6,8-nonadienyl]-;2,6-Piperidinedione, 4-[(2R,5S,6E)-2-hydroxy-5,7-dimethyl-4-oxo-6,8-nonadien-1-yl]-
- CBNumber
- CB21257854
- Molecular Formula
- C16H23NO4
- Formula Weight
- 293.36
- MOL File
- 738-72-7.mol
4-[(2R,5S,6E)-2-hydroxy-5,7-dimethyl-4-oxo-nona-6,8-dienyl]piperidine- 2,6-dione Property
- storage temp.
- Store at -20°C, protect from light
- solubility
- Soluble in DMSO
N-Bromosuccinimide Price
- Product number
- 29984
- Product name
- Streptimidone
- Packaging
- 500μg
- Price
- $189
- Updated
- 2024/03/01
- Product number
- 29984
- Product name
- Streptimidone
- Packaging
- 5mg
- Price
- $946
- Updated
- 2023/06/20
4-[(2R,5S,6E)-2-hydroxy-5,7-dimethyl-4-oxo-nona-6,8-dienyl]piperidine- 2,6-dione Chemical Properties,Usage,Production
Definition
ChEBI: Streptimidone is a tetrahydropyridine.
Biological Activity
Streptimidone is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities.1,2,3 It inhibits protein synthesis in a cell-free assay when used at a concentration of 50 μg/ml.2 Streptimidone (20 and 100 μg/disc) inhibits the growth of S. cerevisiae and the plant pathogenic fungus C. miyabeanus in a disc diffusion assay.1 It reduces tumor growth in H.S. No. 1 human sarcoma and H.Ep. No. 3 human epidermoid carcinoma rat xenograft models when administered at doses of 12.5 and 25 mg/kg per day.3
References
|1. Kondo, H., Oritani, T., and Kiyota, H. Synthesis and antifungal activity of the four stereoisomers of streptimidone, a glutarimide antibiotic from Streptomyces rimosus forma paromomycinus. Eur. J. Org. Chem. (20), 3459-3462 (2000).|2. Bennett, L.L., Ward, V.L., and Brockman, R.W. Inhibition of protein synthesis in vitro by cycloheximide and related glutarimide antibiotics. Biochim. Biophys. Acta. 103(3), 478-485 (1965).|3. Teller, M.N. Antibiotics in experimental cancer chemotherapy. Trans. N. Y. Acad. Sc. 24, 158-166 (1961).
4-[(2R,5S,6E)-2-hydroxy-5,7-dimethyl-4-oxo-nona-6,8-dienyl]piperidine- 2,6-dione Preparation Products And Raw materials
Raw materials
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