methyl 3-hydroxy-5-nitro-benzoate
- Product Name
- methyl 3-hydroxy-5-nitro-benzoate
- CAS No.
- 55076-32-9
- Chemical Name
- methyl 3-hydroxy-5-nitro-benzoate
- Synonyms
- methyl 3-hydroxy-5-nitro-benzoate;3-hydroxy-5-nitrobenzoic acid, methyl ester;Benzoic acid, 3-hydroxy-5-nitro-, methyl ester
- CBNumber
- CB21259737
- Molecular Formula
- C8H7NO5
- Formula Weight
- 197.14
- MOL File
- 55076-32-9.mol
methyl 3-hydroxy-5-nitro-benzoate Property
- Melting point:
- 154-156 °C
- Boiling point:
- 377.2±27.0 °C(Predicted)
- Density
- 1.432±0.06 g/cm3(Predicted)
- pka
- 7.52±0.10(Predicted)
- form
- powder
- color
- Light yellow
Safety
- HS Code
- 2918290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M320115
- Product name
- Methyl3-Hydroxy-5-nitrobenzoate
- Packaging
- 250mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- M320115
- Product name
- Methyl3-Hydroxy-5-nitrobenzoate
- Packaging
- 500mg
- Price
- $195
- Updated
- 2021/12/16
- Product number
- CHM0152041
- Product name
- METHYL 3-HYDROXY-5-NITROBENZOATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.98
- Updated
- 2021/12/16
- Product number
- 8016AB
- Product name
- Methyl3-hydroxy-5-nitrobenzoate
- Packaging
- 10g
- Price
- $844
- Updated
- 2021/12/16
- Product number
- CD12061944
- Product name
- Methyl3-hydroxy-5-nitrobenzoate
- Purity
- 95+%
- Packaging
- 10g
- Price
- $660
- Updated
- 2021/12/16
methyl 3-hydroxy-5-nitro-benzoate Chemical Properties,Usage,Production
Uses
Methyl 3-hydroxy-5-nitrobenzoate is a derivative of benzoic acid (B203900). Methyl 3-hydroxy-5-nitrobenzoate is used in synthetic preparations.
Synthesis
67-56-1
78238-14-9
55076-32-9
1. 3-Hydroxy-5-nitrobenzoic acid (3.7 g, 20.00 mmol) was dissolved in methanol (70.0 mL) at 0 °C. 2. Thionyl chloride (12.0 mL) was slowly added to the above solution. 3. The temperature of the reaction mixture was raised to 6 °C and stirred continuously for 3 hours. 4. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. 5. Water was added to the residue and subsequently extracted with ethyl acetate. 6. The organic phases were combined, washed with saturated brine and dried over anhydrous sodium sulfate. 7. After filtration, the organic phase was concentrated under reduced pressure to afford the crude product methyl 3-hydroxy-5-nitrobenzoate (3.9 g) as an off-white solid which did not require further purification. 8. The structure of the product was determined by 1H-1H-beta-hydroxy-5-nitrobenzoic acid. 8. The structure of the product was confirmed by 1H-NMR (300 MHz, DMSO-d6): δ 10.96 (s, 1H), 8.08 (m, 1H), 7.78 (m, 1H), 7.70 (m, 1H), 3.90 (s, 3H).
References
[1] Journal of Medicinal Chemistry, 2016, vol. 59, # 10, p. 4812 - 4830
[2] Patent: US2014/350007, 2014, A1. Location in patent: Paragraph 0076; 0077; 0078
[3] Journal of Medicinal Chemistry, 1984, vol. 27, # 12, p. 1549 - 1559
[4] Patent: US2010/69431, 2010, A1. Location in patent: Page/Page column 110-111
[5] Patent: WO2014/196793, 2014, A1. Location in patent: Page/Page column 74