ChemicalBook > CAS DataBase List > Eflornithine hydrochloride hydrate

Eflornithine hydrochloride hydrate

Product Name: Eflornithine hydrochloride hydrate
CAS No.: 96020-91-6
Chemical Name: Eflornithine hydrochloride hydrate
Synonyms: Vaniqa;Unii-4nh22ndw9h;DFMO EFLORNITHINE;Eflornithine HCl API;Eflornithine HCl hydrate;DMFO HCl/Eflornithine HCl;Eflornithine HCl Monohydrate;Eflornithine HCl hydrate (DFMO;MDL-71782 hydrochloride hydrate;RMI-71782 hydrochloride hydrate
CBNumber: CB21261062
Molecular Formula: C6H15ClF2N2O3
Formula Weight: 236.64
MOL File: 96020-91-6.mol

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Eflornithine hydrochloride hydrate Property

Melting point:: >210°C (dec.)
storage temp.: Inert atmosphere,2-8°C
solubility: Soluble in Water (up to 25 mg/ml).
form: White powder
color: White
Water Solubility: water: 1mg/mL
methanol: 25mg/mL
Merck: 14,3522
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
InChI: InChI=1S/C6H12F2N2O2.ClH.H2O/c7-4(8)6(10,5(11)12)2-1-3-9;;/h4H,1-3,9-10H2,(H,11,12);1H;1H2
InChIKey: FJPAMFNRCFEGSD-UHFFFAOYSA-N
SMILES: C(N)(C(=O)O)(C(F)F)CCCN.Cl.O
CAS DataBase Reference: 96020-91-6

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Safety

RTECS: RM2981900
HS Code: 2922493800

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1234249
Product name: Eflornithine hydrochloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 150MG
Price: $455
Updated: 2025/07/31

TCI Chemical

Product number: E0947
Product name: Eflornithine Hydrochloride Monohydrate
Purity: >98.0%(T)
Packaging: 200mg
Price: $222
Updated: 2025/07/31

Cayman Chemical

Product number: 16889
Product name: DL-α-Difluoromethylornithine (hydrochloride hydrate)
Purity: ≥98%
Packaging: 25mg
Price: $25
Updated: 2024/03/01

Cayman Chemical

Product number: 16889
Product name: DL-α-Difluoromethylornithine (hydrochloride hydrate)
Purity: ≥98%
Packaging: 50mg
Price: $45
Updated: 2024/03/01

Cayman Chemical

Product number: 16889
Product name: DL-α-Difluoromethylornithine (hydrochloride hydrate)
Purity: ≥98%
Packaging: 100mg
Price: $75
Updated: 2024/03/01

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Eflornithine hydrochloride hydrate Chemical Properties,Usage,Production

Description

Difluoromethylornithine HCl (96020-91-6) is a selective inhibitor of ornithine decarboxylase.1?Induces apoptosis in a variety of cells.2?Difluoromethylornithine HCl displays cancer chemopreventive activity.3?Cell permeable. Active in vivo.

Chemical Properties

White Solid

Uses

Eflornithine hydrochloride hydrate is irreversible inhibitor of ornithine decarboxylase, an enzyme involved in polyamine biosynthesis. Antineoplastic; antipneumocystic; antiprotozoal (Trypanosoma). Used in the treatment of hirsutism.

Definition

ChEBI: Eflornithine hydrochloride monohydrate is the hydrochloride and hydrate of the trypanocidal drug eflornithine. It is a hydrochloride and a hydrate. It contains an eflornithine.

brand name

Ornidyl (Sanofi Aventis); Vaniqa (Skinmedica).

General Description

A cell-permeable, anticancer agent that acts as a specific and irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Inhibits B16 melanoma-induced angiogenesis in ovo and proliferation of vascular endothelial cells in vitro.

Biochem/physiol Actions

Primary TargetODC

References

[1] VERMA A K. Inhibition of tumor promotion by DL-alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase.[J]. Basic life sciences, 1990, 52: 195-204. DOI:10.1007/978-1-4615-9561-8\_16
[2] Y TAKAHASHI K N M Mai. alpha-difluoromethylornithine induces apoptosis as well as anti-angiogenesis in the inhibition of tumor growth and metastasis in a human gastric cancer model.[J]. International Journal of Cancer, 2000, 85 2: 243-247.
[3] F L MEYSKENS E W G. Development of difluoromethylornithine (DFMO) as a chemoprevention agent.[J]. Clinical Cancer Research, 1999, 5 5: 945-951.

Eflornithine hydrochloride hydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Eflornithine hydrochloride hydrate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Eflornithine hydrochloride hydrate 96020-91-6
Price: US $1.00/g
Min. Order: 10g
Purity: 98.0%～ 102.0%
Supply Ability: 200kg/month
Release date: 2021-06-10

Henan Aochuang Chemical Co.,Ltd.

Product: Eflornithine hydrochloride hydrate 96020-91-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-16

Zhuozhou Wenxi import and Export Co., Ltd

Product: Eflornithine hydrochloride hydrate 96020-91-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

96020-91-6, Eflornithine hydrochloride hydrateRelated Search:

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DFMO EFLORNITHINE

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eflornithine,Eflornithinehydrochloridehydrate

Eflornithine hydrochloride hydrate

Eflornithine hydrochloride monohydrate

Unii-4nh22ndw9h

Vaniqa

Eflornithine HCl API

DFMO · HCl · H2O, Eflornithine · HCl · H2O, a-DifluoroMethylornithine · HCl · H2O

H-a-Difluoro-Me-DL-Orn-OH · HCl · H2O

Eflornithine HCl Monohydrate

DL-α-Difluoromethylornithine Hydrochloride Monohydrate

Eflornithine HCl hydrate

MDL-71782 hydrochloride hydrate

RMI-71782 hydrochloride hydrate

α-difluoromethylornithine hydrochloride hydrate

Ornithine,2-(difluoromethyl)-, hydrochloride, hydrate (1:1:1)

DL-α-Difluoromethylornithine, Hydrochloride - CAS 96020-91-6 - Calbiochem

EflornithineHydrochlorideMonohydrate&gt

DL-α-Difluoromethylornithine (hydrochloride hydrate)

DL-α-DifluoromethylornithineHydrochlorideMonohydrate

Eflornithine hydrochloride salt

Eflornithine hydrochloride 1-hydrate

H-α-Difluoro-Me-DL-Orn-OH · HCl · H?O

Eflornithine HCl hydrate (DFMO

Eflornithine Hydrochloride (1234249)

2-(difluoromethyl)-Ornithine hydrochloride hydrate (1:1:1)

Eflornithine (DFMO) hydrochloride hydrate

Yifluoroornithine hydrochloride monohydrate

2-(Difluoromethyl)-ornithine HCl hydrate (1:1:1)

96020-91-6

C6H12F2N2O2HClH2O

C6H15ClF2N2O3

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