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Eflornithine hydrochloride hydrate

Product Name
Eflornithine hydrochloride hydrate
CAS No.
96020-91-6
Chemical Name
Eflornithine hydrochloride hydrate
Synonyms
Vaniqa;Unii-4nh22ndw9h;DFMO EFLORNITHINE;Eflornithine HCl API;Eflornithine HCl hydrate;DMFO HCl/Eflornithine HCl;Eflornithine HCl Monohydrate;Eflornithine HCl hydrate (DFMO;MDL-71782 hydrochloride hydrate;RMI-71782 hydrochloride hydrate
CBNumber
CB21261062
Molecular Formula
C6H15ClF2N2O3
Formula Weight
236.64
MOL File
96020-91-6.mol
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Eflornithine hydrochloride hydrate Property

Melting point:
>210°C (dec.)
storage temp. 
Inert atmosphere,2-8°C
solubility 
Soluble in Water (up to 25 mg/ml).
form 
White powder
color 
White
Merck 
14,3522
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
CAS DataBase Reference
96020-91-6
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Safety

RTECS 
RM2981900
HS Code 
2922493800
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1234249
Product name
Eflornithine hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
150MG
Price
$436
Updated
2024/03/01
TCI Chemical
Product number
E0947
Product name
Eflornithine Hydrochloride Monohydrate
Purity
>98.0%(T)
Packaging
200mg
Price
$247
Updated
2024/03/01
Cayman Chemical
Product number
16889
Product name
DL-α-Difluoromethylornithine (hydrochloride hydrate)
Purity
≥98%
Packaging
25mg
Price
$25
Updated
2024/03/01
Cayman Chemical
Product number
16889
Product name
DL-α-Difluoromethylornithine (hydrochloride hydrate)
Purity
≥98%
Packaging
50mg
Price
$45
Updated
2024/03/01
Cayman Chemical
Product number
16889
Product name
DL-α-Difluoromethylornithine (hydrochloride hydrate)
Purity
≥98%
Packaging
100mg
Price
$75
Updated
2024/03/01
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Eflornithine hydrochloride hydrate Chemical Properties,Usage,Production

Description

Difluoromethylornithine HCl (96020-91-6) is a selective inhibitor of ornithine decarboxylase.1?Induces apoptosis in a variety of cells.2?Difluoromethylornithine HCl displays cancer chemopreventive activity.3?Cell permeable. Active in vivo.

Chemical Properties

White Solid

Uses

Eflornithine hydrochloride hydrate is irreversible inhibitor of ornithine decarboxylase, an enzyme involved in polyamine biosynthesis. Antineoplastic; antipneumocystic; antiprotozoal (Trypanosoma). Used in the treatment of hirsutism.

Definition

ChEBI: Eflornithine hydrochloride monohydrate is the hydrochloride and hydrate of the trypanocidal drug eflornithine. It is a hydrochloride and a hydrate. It contains an eflornithine.

brand name

Ornidyl (Sanofi Aventis); Vaniqa (Skinmedica).

General Description

A cell-permeable, anticancer agent that acts as a specific and irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Inhibits B16 melanoma-induced angiogenesis in ovo and proliferation of vascular endothelial cells in vitro.

Biochem/physiol Actions

Primary TargetODC

References

1) Verma et al. (1990), Inhibition of tumor promotion by DL-alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase; Basic Life Sci., 52 195 2) Takahashi et al. (2000), Alpha-difluoromethylornithine induces apoptosis as well as anti-angiogenesis in the inhibition of tumor growth and metastasis in a human gastric cancer model; Int. J. Cancer, 85 243 3) Meyskens et al. (1999), Development of difluoromethylornithine (DFMO) as a chemoprevention agent; Clin. Cancer Res., 5 945

Eflornithine hydrochloride hydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Eflornithine hydrochloride hydrate Suppliers

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View Lastest Price from Eflornithine hydrochloride hydrate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Eflornithine hydrochloride hydrate 96020-91-6
Price
US $1.00/g
Min. Order
10g
Purity
98.0%～ 102.0%
Supply Ability
200kg/month
Release date
2021-06-10
Henan Aochuang Chemical Co.,Ltd.
Product
Eflornithine hydrochloride hydrate 96020-91-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-16
Zhuozhou Wenxi import and Export Co., Ltd
Product
Eflornithine hydrochloride hydrate 96020-91-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-26

96020-91-6, Eflornithine hydrochloride hydrateRelated Search:

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