apogossypol
- Product Name
- apogossypol
- CAS No.
- 66389-74-0
- Chemical Name
- apogossypol
- Synonyms
- NSC736630;apogossypol;(+)-APOGOSSYPOL;APOGOSSYPOL;NSC736630;(+)Apogossypol,(+) Apogossypol;(+)-3,3'-Dimethyl-5,5'-bis(1-methylethyl)-2,2'-binaphthalene-1,1',6,6',7,7'-hexol;[2,2'-Binaphthalene]-1,1',6,6',7,7'-hexol, 3,3'-dimethyl-5,5'-bis(1-methylethyl)-, (2S)-;3-methyl-5-propan-2-yl-2-(1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)naphthalene-1,6,7-triol
- CBNumber
- CB21268526
- Molecular Formula
- C28H30O6
- Formula Weight
- 462.53
- MOL File
- 66389-74-0.mol
apogossypol Property
- Melting point:
- 118-123 °C
- Boiling point:
- 673.3±50.0 °C(Predicted)
- Density
- 1.335±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- >16.2mg/mL in DMSO with gentle warming
- form
- Powder
- pka
- 8.03±0.50(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B4902
- Product name
- (+)-Apogossypol
- Packaging
- 5mg
- Price
- $333
- Updated
- 2021/12/16
- Product number
- B4902
- Product name
- (+)-Apogossypol
- Packaging
- 10mg
- Price
- $475
- Updated
- 2021/12/16
- Product number
- B4902
- Product name
- (+)-Apogossypol
- Packaging
- 10mM(in 1mL DMSO)
- Price
- $490
- Updated
- 2021/12/16
- Product number
- CSN18376
- Product name
- (+)-Apogossypol
- Packaging
- 5mg
- Price
- $336
- Updated
- 2021/12/16
- Product number
- CD31001130
- Product name
- (+)-Apogossypol
- Purity
- 98+%
- Packaging
- 10mg
- Price
- $350
- Updated
- 2021/12/16
apogossypol Chemical Properties,Usage,Production
Biological Activity
(+)-Apogossypol is a pan-BCL-2 antagonist that binds to Mcl-1, Bcl-2 and Bcl-xL with EC50 of 2.6, 2.8 and 3.69 μM, respectively.
in vitro
In agreement with NMR binding and fluorescence polarization assays (FPAs) data, (+)-Apogossypol displays potent binding affinity to Bcl-xL with K d values of 1.7 μM.
in vivo
Due to its modified structure, (+)-Apogossypol is expected to exhibit lower toxicity while maintaining the significant anti-growth and anti-tumor activities in vitro, similar to those of Gossypol.
target
| Mcl-1 < span> 2.6 μM (EC 50 ) | Bcl-2 2.8 μM (EC 50 ) | Bcl-xL 3.69 μM (EC 50 ) |
apogossypol Preparation Products And Raw materials
Raw materials
Preparation Products
apogossypol Suppliers
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View Lastest Price from apogossypol manufacturers
- Product
- apogossypol 66389-74-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-22