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apogossypol

Product Name
apogossypol
CAS No.
66389-74-0
Chemical Name
apogossypol
Synonyms
NSC736630;apogossypol;(+)-APOGOSSYPOL;APOGOSSYPOL;NSC736630;(+)Apogossypol,(+) Apogossypol;(+)-3,3'-Dimethyl-5,5'-bis(1-methylethyl)-2,2'-binaphthalene-1,1',6,6',7,7'-hexol;[2,2'-Binaphthalene]-1,1',6,6',7,7'-hexol, 3,3'-dimethyl-5,5'-bis(1-methylethyl)-, (2S)-;3-methyl-5-propan-2-yl-2-(1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)naphthalene-1,6,7-triol
CBNumber
CB21268526
Molecular Formula
C28H30O6
Formula Weight
462.53
MOL File
66389-74-0.mol
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apogossypol Property

Melting point:
118-123 °C
Boiling point:
673.3±50.0 °C(Predicted)
Density 
1.335±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
>16.2mg/mL in DMSO with gentle warming
form 
Powder
pka
8.03±0.50(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ApexBio Technology
Product number
B4902
Product name
(+)-Apogossypol
Packaging
5mg
Price
$333
Updated
2021/12/16
ApexBio Technology
Product number
B4902
Product name
(+)-Apogossypol
Packaging
10mg
Price
$475
Updated
2021/12/16
ApexBio Technology
Product number
B4902
Product name
(+)-Apogossypol
Packaging
10mM(in 1mL DMSO)
Price
$490
Updated
2021/12/16
CSNpharm
Product number
CSN18376
Product name
(+)-Apogossypol
Packaging
5mg
Price
$336
Updated
2021/12/16
Crysdot
Product number
CD31001130
Product name
(+)-Apogossypol
Purity
98+%
Packaging
10mg
Price
$350
Updated
2021/12/16
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apogossypol Chemical Properties,Usage,Production

Biological Activity

(+)-Apogossypol is a pan-BCL-2 antagonist that binds to Mcl-1, Bcl-2 and Bcl-xL with EC50 of 2.6, 2.8 and 3.69 μM, respectively.

in vitro

In agreement with NMR binding and fluorescence polarization assays (FPAs) data, (+)-Apogossypol displays potent binding affinity to Bcl-xL with K d values of 1.7 μM.

in vivo

Due to its modified structure, (+)-Apogossypol is expected to exhibit lower toxicity while maintaining the significant anti-growth and anti-tumor activities in vitro, similar to those of Gossypol.

target

Mcl-1

< span> 2.6 μM (EC 50 )

Bcl-2

2.8 μM (EC 50 )

Bcl-xL

3.69 μM (EC 50 )

apogossypol Preparation Products And Raw materials

Raw materials

Preparation Products

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apogossypol Suppliers

China 14 United States 7 Global 21
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
TargetMol Chemicals Inc.
Tel
+8613564774135
Email
zijue.cai@tsbiochem.com
Country
United States
ProdList
19885
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
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View Lastest Price from apogossypol manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
apogossypol 66389-74-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-22

66389-74-0, apogossypolRelated Search:


  • apogossypol
  • (+)-3,3'-Dimethyl-5,5'-bis(1-methylethyl)-2,2'-binaphthalene-1,1',6,6',7,7'-hexol
  • NSC736630
  • APOGOSSYPOL;NSC736630
  • 3-methyl-5-propan-2-yl-2-(1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)naphthalene-1,6,7-triol
  • (+)-APOGOSSYPOL
  • [2,2'-Binaphthalene]-1,1',6,6',7,7'-hexol, 3,3'-dimethyl-5,5'-bis(1-methylethyl)-, (2S)-
  • (+)Apogossypol,(+) Apogossypol
  • 66389-74-0