1H-Benzimidazole-2-carboxamide(9CI)
Uses- Product Name
- 1H-Benzimidazole-2-carboxamide(9CI)
- CAS No.
- 5805-52-7
- Chemical Name
- 1H-Benzimidazole-2-carboxamide(9CI)
- Synonyms
- 2-Benzimidazolecarboxamide;1H-BenziMidazole-2-carboxaMide;1H-1,3-benzodiazole-2-carboxamide;1H-benzo[d]iMidazole-2-carboxaMide;1H-Benzimidazole-2-carboxamide(9CI)
- CBNumber
- CB21275896
- Molecular Formula
- C8H7N3O
- Formula Weight
- 161.16
- MOL File
- 5805-52-7.mol
1H-Benzimidazole-2-carboxamide(9CI) Property
- Melting point:
- >300 °C
- Boiling point:
- 417.6±28.0 °C(Predicted)
- Density
- 1.416±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 10.59±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- FB141355
- Product name
- 1H-Benzo[d]imidazole-2-carboxamide
- Packaging
- 50mg
- Price
- $82
- Updated
- 2021/12/16
- Product number
- Z4905
- Product name
- 1H-Benzo[d]imidazole-2-carboxamide
- Packaging
- 100mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- Z4905
- Product name
- 1H-Benzo[d]imidazole-2-carboxamide
- Packaging
- 250mg
- Price
- $122
- Updated
- 2021/12/16
- Product number
- FB141355
- Product name
- 1H-Benzo[d]imidazole-2-carboxamide
- Packaging
- 100mg
- Price
- $142
- Updated
- 2021/12/16
- Product number
- 119751
- Product name
- 1H-Benzo[d]imidazole-2-carboxamide
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $269
- Updated
- 2021/12/16
1H-Benzimidazole-2-carboxamide(9CI) Chemical Properties,Usage,Production
Uses
1H-benzimidazole-2-carboxamide is a pharmaceutical intermediate that can be used to prepare the Pin1 inhibitor 1,2-disubstituted benzimidazole derivative 2-[1-[3-oxo-(3-anilino)propyl]-1H-benzimidazole-2-yl]thiazolyl-4-carboxylic acid.
Synthesis
2849-93-6
5805-52-7
General procedure for the synthesis of 1H-benzimidazole-2-carboxylic acid from 1H-benzimidazole-2-carboxylic acid: 3.0 g (18.6 mmol) of 1H-benzimidazole-2-carboxylic acid was dissolved in 100 ml of solvent at room temperature, 30 ml of thionyl chloride was added, and the reaction was carried out by refluxing the reaction for 4 hours at 79°C. After completion of the reaction, the solvent was removed by distillation under reduced pressure. To the residue was added 30 ml of ammonia and the reaction was carried out at 70 °C for 5 hours. The reaction solution was cooled and filtered to give a yellow solid product, which was dried to give the target compound. The yield was 55.0%.
References
[1] Patent: CN106905241, 2017, A. Location in patent: Paragraph 0133-0135
[2] Patent: CN107118249, 2017, A. Location in patent: Paragraph 0132; 0133; 0134
[3] Biochemische Zeitschrift, 1956, vol. 327, p. 422,447
1H-Benzimidazole-2-carboxamide(9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1H-Benzimidazole-2-carboxamide(9CI) manufacturers
- Product
- 1H-Benzimidazole-2-carboxamide(9CI) 5805-52-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-14