2(1H)-Pyridinone,4-(hydroxymethyl)-(9CI)
- Product Name
- 2(1H)-Pyridinone,4-(hydroxymethyl)-(9CI)
- CAS No.
- 127838-58-8
- Chemical Name
- 2(1H)-Pyridinone,4-(hydroxymethyl)-(9CI)
- Synonyms
- 4-(Hydroxymethyl)-2(1H)-p...;2-Hydroxypyridine-4-methanol;4-(Hydroxymethyl)pyridin-2-ol;2-Hydroxy-4-(methanol)pyridine;4-(Hydroxymethyl)pyridin-2(1H)-one;4-(HydroxyMethyl)-2(1H)-pyridinone;4-(hydroxymethyl)-1H-pyridin-2-one;2(1H)-Pyridinone, 4-(hydroxymethyl)-;2(1H)-Pyridinone,4-(hydroxymethyl)-(9CI);4-(hydroxymethyl)-1,2-dihydropyridin-2-one
- CBNumber
- CB21302015
- Molecular Formula
- C6H7NO2
- Formula Weight
- 125.13
- MOL File
- 127838-58-8.mol
2(1H)-Pyridinone,4-(hydroxymethyl)-(9CI) Property
- Melting point:
- 144-145 °C
- Boiling point:
- 428.0±27.0 °C(Predicted)
- Density
- 1.225±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 11.67±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- H973020
- Product name
- 4-(Hydroxymethyl)-2(1H)-pyridinone
- Packaging
- 500mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- CS-0033712
- Product name
- 4-(Hydroxymethyl)pyridin-2(1H)-one
- Purity
- >97.0%
- Packaging
- 250mg
- Price
- $66
- Updated
- 2021/12/16
- Product number
- 4H56-1-MN
- Product name
- 4-(Hydroxymethyl)-2(1H)-pyridinone
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 068720
- Product name
- 4-(Hydroxymethyl)-2(1H)-pyridinone
- Purity
- >95%
- Packaging
- 250mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 068720
- Product name
- 4-(Hydroxymethyl)-2(1H)-pyridinone
- Purity
- >95%
- Packaging
- 500mg
- Price
- $146
- Updated
- 2021/12/16
2(1H)-Pyridinone,4-(hydroxymethyl)-(9CI) Chemical Properties,Usage,Production
Synthesis
89937-77-9
127838-58-8
General procedure for the synthesis of 4-(hydroxymethyl)pyridin-2(1H)-one from methyl 2-hydroxypyridine-4-carboxylate: to an anhydrous tetrahydrofuran (23 mL) suspension of methyl 2-methoxy-1,2-dihydro-4-pyridinecarboxylate (1.37 g, 8.98 mmol) was added slowly and dropwise 2 M lithium borohydride/tetrahydrofuran solution (22.5 mL, 45 mmol). The reaction mixture was heated to 55 °C and maintained for 3.5 h under nitrogen protection. Upon completion of the reaction, methanol (15 mL) and water (3 mL) were carefully added, followed by stirring for 30 min at room temperature. The mixture was concentrated and methanol (10 mL) was again carefully added. After continued stirring for 30 min, the mixture was adsorbed onto silica gel and purified by silica gel column chromatography using a 0 to 30% methanol-dichloromethane gradient elution to afford the target product, 4-(hydroxymethyl)pyridin-2(1H)-one, as an off-white solid (0.99 g, 88% yield). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 11.29 (br s, 1H), 7.23 (d, J = 6.7 Hz, 1H), 6.21 (s, 1H), 6.03 (dd, J = 6.7, 1.3 Hz, 1H), 5.27 (t, J = 5.9 Hz, 1H), 4.28 (d, J = 5.9 Hz, 2H).
References
[1] Patent: WO2009/76387, 2009, A1. Location in patent: Page/Page column 30
[2] Patent: WO2014/31936, 2014, A2. Location in patent: Paragraph 0344; 0345
[3] Chemical and Pharmaceutical Bulletin, 1990, vol. 38, # 1, p. 288 - 290
[4] Patent: US2003/220241, 2003, A1
2(1H)-Pyridinone,4-(hydroxymethyl)-(9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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