5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDE
- Product Name
- 5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDE
- CAS No.
- 184241-44-9
- Chemical Name
- 5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDE
- Synonyms
- NBI27914HCl;NBI 27914 hydrochlor;NBI 27914 >=98% (HPLC);NBI 27914 HYDROCHLORIDE;4,6-Pyrimidinediamine, 5-chloro-N4-(cyclopropylmethyl)-2-methyl-N4-propyl-N6-(2,4,6-trichlorophenyl)-;5-Chloro-N-(cyclopropylmethyl)-2-methyl-N-propyl-N'-(2,4,6-trichlorophenyl)-4,6-pyrimidinediaminehydrochloride;5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDE
- CBNumber
- CB2130693
- Molecular Formula
- C18H20Cl4N4
- Formula Weight
- 434.19
- MOL File
- 184241-44-9.mol
5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDE Property
- Boiling point:
- 483.7±45.0 °C(Predicted)
- Density
- 1.417±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 16 mg/mL at 60 °C, soluble
- form
- solid
- pka
- 3.58±0.50(Predicted)
- color
- white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- N3911
- Product name
- NBI 27914
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $112.2
- Updated
- 2024/03/01
- Product number
- N3911
- Product name
- NBI 27914
- Purity
- ≥98% (HPLC)
- Packaging
- 50mg
- Price
- $691
- Updated
- 2022/05/15
- Product number
- 1591
- Product name
- NBI27914hydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $173
- Updated
- 2021/12/16
- Product number
- 1591
- Product name
- NBI27914hydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $724
- Updated
- 2021/12/16
- Product number
- 255950
- Product name
- NBI 27914 hydrochloride
- Packaging
- 10mg
- Price
- $423
- Updated
- 2021/12/16
5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDE Chemical Properties,Usage,Production
Uses
NBI 27914 has been used as acorticotropin-releasing hormone receptor (CRHR1) antagonist:
- to study its effects on steroidogenic gene expression in GD15 mouse testis
- to study its effects on amyloid β production
- to study its effects on neurogenic activity of neural stem cells in the adult hippocampus
Definition
ChEBI: 5-chloro-N4-(cyclopropylmethyl)-2-methyl-N4-propyl-N6-(2,4,6-trichlorophenyl)pyrimidine-4,6-diamine is a dialkylarylamine and a tertiary amino compound.
Biological Activity
Selective, non-peptide corticotropin-releasing factor 1 (CRF 1 ) receptor antagonist (K i = 1.7 nM); has no activity at CRF 2 receptors. Blocks behavioral seizures in vivo .
Biochem/physiol Actions
NBI 27914 is a CRF1 corticotropin-releasing factor receptor antagonist.
5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDE Suppliers
- Tel
- --
- Fax
- --
- sales@chemos-group.com
- Country
- Germany
- ProdList
- 6350
- Advantage
- 71
- Tel
- --
- Fax
- --
- info@biotrend.ch
- Country
- Germany
- ProdList
- 1250
- Advantage
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