GS 283
- Product Name
- GS 283
- CAS No.
- 149440-36-8
- Chemical Name
- GS 283
- Synonyms
- GS 283;6,7-Isoquinolinediol, 3,4-dihydro-1-[(4-methoxyphenyl)methyl]-
- CBNumber
- CB21308299
- Molecular Formula
- C17H17NO3
- Formula Weight
- 283.32
- MOL File
- 149440-36-8.mol
GS 283 Chemical Properties,Usage,Production
Description
GS 283 is a Ca(2+) antagonist and a weak histamine & muscarinic receptor blocker in rat & guinea pig tracheal smooth muscles. Its mode of action is inhibition of calcium influx from plasma membrane & also release from sarcoplasmic reticulum.
Uses
GS 283 is a compound with calcium antagonist and weak histamine and muscarinic receptor blocking activity, with activity in modulating contraction of guinea pig and rat tracheal smooth muscle. GS 283 inhibits contractions induced by carbachol, histamine (guinea pig only), and high H+ in guinea pig and rat tracheal smooth muscle, inhibits Ca2+-induced contractions in guinea pig tracheal smooth muscle, and at high concentrations completely abolishes contractions induced by carbachol in Ca2+-free medium.
References
[1] Pharmacological characterization of effects of verapamil and GS 283 on isolated guinea pig and rat trachealis DOI:10.1016/0014-2999(93)90226-8
GS 283 Preparation Products And Raw materials
Raw materials
Preparation Products
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