N(4)-hydroxycytidine

ChemicalBook > CAS DataBase List > N(4)-hydroxycytidine

N(4)-hydroxycytidine

Product Name: N(4)-hydroxycytidine
CAS No.: 3258-02-4
Chemical Name: N(4)-hydroxycytidine
Synonyms: EIDD-1931;N-Hydroxycytidine;0/4/58;EIDD-193;Engagliflozin;Uridine, 4-oxime;Monovir impurity A;EIDD 2801-metabolit;EIDD2801-metabolite;N(4)-hydroxycytidine
CBNumber: CB21312265
Molecular Formula: C9H13N3O6
Formula Weight: 259.22
MOL File: 3258-02-4.mol

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N(4)-hydroxycytidine Property

Melting point:: 169-172 °C(Solv: methanol (67-56-1))
Density: 1.93±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Soluble in DMSO (up to 25 mg/ml) or in Water (up to 15 mg/ml with warming).
pka: 8.19±0.20(Predicted)
form: solid
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2872
Product name: EIDD-1931
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $94.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2872
Product name: EIDD-1931
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $381
Updated: 2024/03/01

Cayman Chemical

Product number: 9002958
Product name: EIDD-1931
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 9002958
Product name: EIDD-1931
Packaging: 5mg
Price: $87
Updated: 2024/03/01

Cayman Chemical

Product number: 9002958
Product name: EIDD-1931
Packaging: 10mg
Price: $155
Updated: 2024/03/01

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N(4)-hydroxycytidine Chemical Properties,Usage,Production

Description

EIDD-1931 is a ribonucleoside analog with antiviral activity. It inhibits replication of severe acute respiratory syndrome coronavirus (SARS-CoV) in Vero 76 cells, Middle East respiratory syndrome coronavirus (MERS-CoV) in Calu-3 2B4 cells, and SARS-CoV-2 in Vero cells (IC₅₀s =0.1, 0.15 and 0.3 μM, respectively). It also reduces viral titers of Venezuelan equine encephalitis virus (VEEV) TC-83 in infected Vero cells (EC₅₀ = 0.426 μM) and wild-type and remdesivir-resistant strains of the model CoV mouse hepatitis virus (MHV) in infected DBT cells. EIDD-1931 (100 and 400 mg/kg twice per day) reduces lung viral titers in mouse models of respiratory syncytial virus (RSV) and H1N1 influenza A virus infection.

Uses

EIDD 1931 is an orally bioavailable broad-spectrum antiviral that inhibits SARS-CoV-2 and other multiple endemic, epidemic and bat coronavirus and has the potential for seasonal and pandemic influenza treatment. A broad-spectrum ribonucleoside analog inhibitor of influenza and respiratory syncytial viruses.

Definition

ChEBI: N(4)-hydroxycytidine is a nucleoside analogue that is cytidine which carries a hydroxy group at the N(4)-positon. It has broad-spectrum antiviral activity against influenza, SARS-CoV , SARS-CoV-2 and MERS-CoV. It has a role as a drug metabolite, a human xenobiotic metabolite, an anticoronaviral agent and an antiviral agent. It is a nucleoside analogue and a ketoxime. It is functionally related to a cytidine.

storage

Store at -20°C

References

1) Janion and Glickman (1980),?N4-hydroxycytidine: a mutagen specific for AT to GC transitions;?Mutat. Res.,?72?43 2) Stuyver?et al.?(2003),?Ribonucleotide analogue that blocks replication of bovine viral diarrhea and hepatitis C viruses in culture; Antimicrob. Agents Chemother.,?47?244 3) Costantini?et al.?(2012),?Antiviral activity of nucleoside analogues against norovirus; Antivir. Ther.,?17?981 4) Reynard?et al.?(2015),?Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication; Viruses,?7?6233 5) Ehteshami?et al.?(2017),?Characterization of ?-D-N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus; Antimicrob. Agents Chemother.,?61?e02395-16 6) Yoon?et al.?(2018),?Orally efficacious broad-spectrum ribonucleoside analog inhibitor of influenza and respiratory syncytial viruses; Antimicrob. Agents Chemother.,?62?e00766-18 7) Barnard?et al.?(2004),?Inhibition of severe acute respiratory syndrome-associated coronavirus (SARSCoV) by calpain inhibitors and beta-D-N4-hydroxycytidine; Antivir. Chem. Chemother., 15 15 8) Pyrc et al. (2006),?Inhibition of human coronavirus NL63 infection at early stages of the replication cycle; Antimicrob. Agents Chemother.,?50?2000 9) Toots et al. (2019),?Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia; Sci. Transl. Med.,?11?eaax5866

N(4)-hydroxycytidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N(4)-hydroxycytidine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: N(4)-hydroxycytidine 3258-02-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20T
Release date: 2024-07-11

Shanghai Biolang Biotechnology Co., Ltd.

Product: N(4)-hydroxycytidine 3258-02-4
Price: US $9.90-8.80/g
Min. Order: 10g
Purity: 99.99%HPLC.USP42
Supply Ability: 1000kgs
Release date: 2022-02-10

3258-02-4, N(4)-hydroxycytidineRelated Search:

Molnupiravir PF-01367338 RESINIFERATOXIN N-Eicosanoyl Serotonin Imiquimod ((2R,3S,4R)-3,4,5-trihydroxytetrahydrofuran-2-yl)methyl isobutyrate Uridine, 5'-(2-methylpropanoate) (9CI) Cytidine, 2',3'-O-(1-methylethylidene)-, 5'-(2-methylpropanoate) ((3aR,4R,6R,6aR)-6-((E)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl isobutyrate Uridine, 4-oxime, 5'-(2-methylpropanoate), (4E)- 2,4(1H,3H)-Pyrimidinedione, 1-β-L-ribofuranosyl-, 4-oxime (9CI) 6-HYDROXYLAMINOURACIL 2',3'-O-isopropylidene cytidine 1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one Molnupiravir Impurity 5

N(4)-hydroxycytidine

1-[(2R)-3α,4α-Dihydroxy-5β-(hydroxymethyl)oxolane-2β-yl]-4-(hydroxyamino)pyrimidine-2(1H)-one

3,4-Dihydro-1-β-D-ribofuranosyl-4-(hydroxyimino)pyrimidin-2(1H)-one

N-Hydroxycytidine

β-D-N4-Hydroxycytidine

Beta-d-N4-hydroxycytidine

EIDD-1931

Beta-d-N4-hydroxycytidine (NHC)

Uridine, 4-oxime

EIDD2801 ,β-D-N4-hydroxycytidine

EIDD-193

Molnupiravir Impurity 1

Molnupiravir Impurity A/N-hydroxycytidine

0/4/58

EIDD-1931 (Beta-d-N4-hydroxycytidine

1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-oneQ: What is 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-one Q: What is the CAS Number of 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-one Q: What is the storage condition of 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-one

N-Hydroxycytidine (EIDD-1931) for cell culture, 98%, Endotoxin (BET) 0.05EU/mg

Chikungunya,equine,Enterovirus,HEV,EIDD 1931,HRV,Hepatitis C virus,Inhibitor,EIDD1931,CHIKV,Topoisomerase,Enterovirus,VEEV,HEVs,NHC,Rhinovirus,HCV,encephalitis,SARS-CoV,EIDD-1931,inhibit,venezuelan,HRVs,SARS coronavirus

1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Oxolan-2-Yl]-4-(Hydroxyamino)Pyrimidin-2-One

1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-one (Molnupiravir Impurity)

Monovir impurity A

N4-Hydroxycytidine (NHC)

EIDD 2801-metabolit

EIDD-2801-metabolite

EIDD2801-metabolite

13C,15N3]-2'-Deoxycytidine

Engagliflozin

Monabiravir impurity 1

3258-02-4

328-02-4