alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol
- Product Name
- alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol
- CAS No.
- 105565-56-8
- Chemical Name
- alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol
- Synonyms
- BMY-14802 >=97% (HPLC);BMY-14802, 10 mM in DMSO;1-Piperazinebutanol, α-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-;alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol;1-(4-Fluorophenyl)-4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)butan-1-ol
- CBNumber
- CB21320709
- Molecular Formula
- C18H22F2N4O
- Formula Weight
- 348.39
- MOL File
- 105565-56-8.mol
alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol Property
- Boiling point:
- 520.8±60.0 °C(Predicted)
- Density
- 1.256±0.06 g/cm3(Predicted)
- pka
- 14.28±0.20(Predicted)
- form
- Solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- API0015051
- Product name
- ALPHA-(4-FLUOROPHENYL)-4-(5-FLUORO-2-PYRIMIDINYL)-1-PIPERAZINE BUTANOL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.76
- Updated
- 2021/12/16
alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol Chemical Properties,Usage,Production
Uses
BMY 14802 is a sigma-1 receptor (σ1R) antagonist, as well as an agonist at serotonin (5-HT) 1A and adrenergic alpha-1 receptors. BMY 14802 inhibits abnormal involuntary movement (AIM) in rat Parkinson's disease (PD) model, with down-regulating the expression of AIM[1][2].
Definition
ChEBI: 1-(4-fluorophenyl)-4-[4-(5-fluoro-2-pyrimidinyl)-1-piperazinyl]-1-butanol is a N-arylpiperazine.
in vivo
BMY 14802 (15 mg/kg; i.p.; single dose) significantly inhibits AIM and decreases dyskinesias, especially in the first hour in rat PD model[1][2].
IC 50
Sigma 1 Receptor; 5-HT1A Receptor; α1-adrenergic receptor
References
[1] Paquette MA, et al. The sigma-1 antagonist BMY-14802 inhibits L-DOPA-induced abnormal involuntary movements by a WAY-100635-sensitive mechanism. Psychopharmacology (Berl). 2009 Jul;204(4):743-54. DOI:10.1007/s00213-009-1505-8
[2] Paquette MA, et al. Sigma ligands, but not N-methyl-D-aspartate antagonists, reduce levodopa-induced dyskinesias. Neuroreport. 2008 Jan 8;19(1):111-5. DOI:10.1097/WNR.0b013e3282f3b0d1
alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol Preparation Products And Raw materials
Raw materials
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