4-(3,4-DICHLORO-PHENYL)-2,4-DIOXO-BUTYRIC ACID METHYL ESTER

Product Name: 4-(3,4-DICHLORO-PHENYL)-2,4-DIOXO-BUTYRIC ACID METHYL ESTER
CAS No.: 374679-63-7
Chemical Name: 4-(3,4-DICHLORO-PHENYL)-2,4-DIOXO-BUTYRIC ACID METHYL ESTER
Synonyms: AKOS B016273;ART-CHEM-BB B016273;SALOR-INT L100021-1EA;Methyl 3,4-dichloro-α,γ-dioxobenzenebutanoate;Methyl 3,4-dichloro-α,γ-dioxobenzenebutanoate;Methyl 3,4-dichloro-a,g-dioxo-benzenebutanoate;METHYL 4-(3,4-DICHLOROPHENYL)-2,4-DIOXOBUTANOATE;Benzenebutanoic acid, 3,4-dichloro-α,γ-dioxo-, methyl ester;4-(3,4-DICHLORO-PHENYL)-2,4-DIOXO-BUTYRIC ACID METHYL ESTER
CBNumber: CB2133270
Molecular Formula: C11H8Cl2O4
Formula Weight: 275.08
MOL File: Mol file

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4-(3,4-DICHLORO-PHENYL)-2,4-DIOXO-BUTYRIC ACID METHYL ESTER Property

Melting point:: 127-129°C
Boiling point:: 423.0±40.0 °C(Predicted)
Density: 1.410±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 5.72±0.48(Predicted)
Appearance: Off-white to light yellow Solid

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Safety

HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: L100021
Product name: METHYL 4-(3,4-DICHLOROPHENYL)-2,4-DIOXOBUTANOATE
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $30.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: L100021
Product name: METHYL 4-(3,4-DICHLOROPHENYL)-2,4-DIOXOBUTANOATE
Purity: AldrichCPR
Packaging: 10MG
Price: $29.8
Updated: 2024/03/01

TRC

Product number: T806505
Product name: Methyl4-(3,4-Dichlorophenyl)-2,4-dioxobutanoate
Packaging: 100mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: 4786AB
Product name: Methyl4-(3,4-dichlorophenyl)-2,4-dioxobutanoate
Packaging: 1g
Price: $65
Updated: 2021/12/16

Matrix Scientific

Product number: 044520
Product name: Methyl 4-(3,4-dichlorophenyl)-2,4-dioxobutanoate
Purity: >95%
Packaging: 5g
Price: $150
Updated: 2021/12/16

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4-(3,4-DICHLORO-PHENYL)-2,4-DIOXO-BUTYRIC ACID METHYL ESTER Chemical Properties,Usage,Production

Synthesis

553-90-2

2642-63-9

374679-63-7

General procedure for the synthesis of methyl 4-(3,4-dichlorophenyl)-2,4-dicarbonylbutyrate from dimethyl oxalate and 3,4-dichloroacetophenone: dimethyl oxalate (5.9 g, 50 mmol) was slowly added to a suspension of freshly prepared sodium methanolate (3.24 g, 60 mmol) in anhydrous toluene at 8-10 °C. Subsequently, 3,4-dichloroacetophenone (6.7 g, 50 mmol) was added dropwise over 30 min. The reaction mixture was stirred overnight at 8-10 °C and under nitrogen protection. After completion of the reaction, the yellow precipitate was obtained by filtration and washed with toluene (2 x 20 ml), then the precipitate was dissolved in water (20 mL) and acidified by adding 25 ml of 6N HCl. The organic layer was extracted with diisopropyl ether, followed by washing the organic layer with brine, drying with anhydrous sodium sulfate, and finally evaporating the solvent to give pure methyl 4-(3,4-dichlorophenyl)-2,4-dicarbonylbutyrate (8a-e) as a yellow solid in good yield.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 8, p. 2077 - 2083
[2] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 1, p. 273 - 280

4-(3,4-DICHLORO-PHENYL)-2,4-DIOXO-BUTYRIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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374679-63-7, 4-(3,4-DICHLORO-PHENYL)-2,4-DIOXO-BUTYRIC ACID METHYL ESTERRelated Search:

AKOS B016273

4-(3,4-DICHLORO-PHENYL)-2,4-DIOXO-BUTYRIC ACID METHYL ESTER

METHYL 4-(3,4-DICHLOROPHENYL)-2,4-DIOXOBUTANOATE

ART-CHEM-BB B016273

SALOR-INT L100021-1EA

Methyl 3,4-dichloro-a,g-dioxo-benzenebutanoate

Benzenebutanoic acid, 3,4-dichloro-α,γ-dioxo-, methyl ester

Methyl 3,4-dichloro-α,γ-dioxobenzenebutanoate

374679-63-7

C11H8Cl2O4