6,7-dichloroquinoline-5,8-dione
- Product Name
- 6,7-dichloroquinoline-5,8-dione
- CAS No.
- 6541-19-1
- Chemical Name
- 6,7-dichloroquinoline-5,8-dione
- Synonyms
- 6，7-dichloro9uinoline-5,8-dione;6,7-dichloroquinoline-5,8-dione;5,8-Quinolinedione, 6,7-dichloro-
- CBNumber
- CB21335666
- Molecular Formula
- C9H3Cl2NO2
- Formula Weight
- 228.03
- MOL File
- 6541-19-1.mol
6,7-dichloroquinoline-5,8-dione Property
- Melting point:
- 220-222 °C
- Boiling point:
- 331.1±42.0 °C(Predicted)
- Density
- 1.63±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Slightly)
- form
- Solid
- pka
- -3.44±0.20(Predicted)
- color
- Pale Yellow to Orange
- InChI
- 1S/C9H3Cl2NO2/c10-5-6(11)9(14)7-4(8(5)13)2-1-3-12-7/h1-3H
- InChIKey
- TUWOPVCIIBKUQS-UHFFFAOYSA-N
- SMILES
- O=C(C(Cl)=C(Cl)C1=O)C2=C1N=CC=C2
Safety
- WGK Germany
- WGK 3
- Storage Class
- 11 - Combustible Solids
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- TMT00350
- Product name
- 6,7-Dichloroquinoline-5,8-dione
- Packaging
- 1 g
- Price
- $550
- Updated
- 2025/07/31
- Product number
- D439940
- Product name
- 6,7-Dichloroquinoline-5,8-dione
- Packaging
- 25g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- A657071
- Product name
- 6,7-Dichloroquinoline-5,8-dione
- Purity
- 98%
- Packaging
- 100mg
- Price
- $62
- Updated
- 2021/12/16
- Product number
- A657071
- Product name
- 6,7-Dichloroquinoline-5,8-dione
- Purity
- 98%
- Packaging
- 250mg
- Price
- $118
- Updated
- 2021/12/16
- Product number
- A657071
- Product name
- 6,7-Dichloroquinoline-5,8-dione
- Purity
- 98%
- Packaging
- 1g
- Price
- $297
- Updated
- 2021/12/16
6,7-dichloroquinoline-5,8-dione Chemical Properties,Usage,Production
Uses
6,7-Dichloroquinoline-5,8-dione is a reagent used in the synthesis of pharmaceuticals, such as a platinum(II) complex with antitumor activity.
Synthesis
148-24-3
6541-19-1
General procedure for the synthesis of 6,7-dichloroquinoline-5,8-dione from 8-hydroxyquinoline: sodium chlorate (0.50 mol) was slowly added to a solution of 8-hydroxyquinoline (0.10 mol) dissolved in concentrated hydrochloric acid (600 mL) over a period of 1 hour. The reaction mixture was stirred continuously at 40°C for 2 hours. Subsequently, the reaction solution was diluted with water to a total volume of 2 L. The resulting white precipitate was removed by filtration and discarded. The filtrate was extracted several times with dichloromethane (6 x 250 mL), all organic phases were combined, washed with water and concentrated under reduced pressure to give a yellow solid product. The solid product was recrystallized in methanol to give the final 6,7-dichloroquinoline-5,8-dione (compound 7) as bright yellow crystals. The characterization data of compound 7 was in agreement with that reported in literature [32].
References
[1] RSC Advances, 2015, vol. 5, # 78, p. 63330 - 63337
[2] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 8, p. 4617 - 4625
[3] Journal of Medicinal Chemistry, 1986, vol. 29, # 8, p. 1329 - 1340
[4] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 9, p. 3238 - 3251
[5] European Journal of Medicinal Chemistry, 2018, vol. 157, p. 423 - 436
6,7-dichloroquinoline-5,8-dione Preparation Products And Raw materials
Raw materials
Preparation Products
6,7-dichloroquinoline-5,8-dione Suppliers
- Tel
- 0731-88827538 15873153880
- Fax
- 0731-88827238
- luxingbc@126.com
- Country
- China
- ProdList
- 1996
- Advantage
- 65
- Tel
- 18696571988
- Fax
- +86 (23) 6777-0220
- amy.lei@chemieliva.com
- Country
- China
- ProdList
- 1556
- Advantage
- 60
- Tel
- 0711-3617768 13308685235
- Fax
- 0711-3616558
- lihongcai4360@sina.com
- Country
- China
- ProdList
- 1538
- Advantage
- 55
- Tel
- 025-58859352 18068836627
- Fax
- 02557626880
- sales01@aikonchem.com
- Country
- China
- ProdList
- 16027
- Advantage
- 58
- Tel
- 021-58581007 18019463053
- Fax
- 021-50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 9732
- Advantage
- 58
- Tel
- 010-82387566 18001021521;
- Fax
- 82387566-801
- sales@mreda.com.cn
- Country
- China
- ProdList
- 10083
- Advantage
- 58
- Tel
- +86-13776644403
- robert@focuspharma.cc
- Country
- China
- ProdList
- 2465
- Advantage
- 58
- Tel
- +8613776644403
- sales02@kingboomtech.com
- Country
- China
- ProdList
- 1804
- Advantage
- 58
- Tel
- 0086-19817745290; +8619817745290
- bd@blocksynth.com
- Country
- China
- ProdList
- 5661
- Advantage
- 58
- Tel
- 0371-53732842 13383863444
- 3838551451@qq.com
- Country
- China
- ProdList
- 9998
- Advantage
- 58