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N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine

Product Name
N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine
CAS No.
515880-75-8
Chemical Name
N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine
Synonyms
DMH-4;DMH4,DMH-4;N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine;6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]-3-phenylpyrazolo[1,5-a]pyriMidine;4-[2-[4-(3-phenylpyrazolo[1,5-a]pyrimidin-6-yl)phenoxy]ethyl]morpholine;Pyrazolo[1,5-a]pyrimidine, 6-[4-[2-(4-morpholinyl)ethoxy]phenyl]-3-phenyl-
CBNumber
CB21337701
Molecular Formula
C24H24N4O2
Formula Weight
400.47
MOL File
515880-75-8.mol
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N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine Property

Density 
1.25±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble20mg/mL
pka
6.28±0.10(Predicted)
form 
powder
color 
off-white to brown
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D8696
Product name
DMH4
Purity
>99.0% (HPLC)
Packaging
5mg
Price
$154
Updated
2022/05/15
Cayman Chemical
Product number
27653
Product name
DMH4
Packaging
1mg
Price
$45
Updated
2024/03/01
Cayman Chemical
Product number
27653
Product name
DMH4
Packaging
25mg
Price
$437
Updated
2024/03/01
Cayman Chemical
Product number
27653
Product name
DMH4
Packaging
5mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
27653
Product name
DMH4
Packaging
10mg
Price
$198
Updated
2024/03/01
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N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine Chemical Properties,Usage,Production

Description

DMH4 is an inhibitor of VEGF receptor 2 (VEGFR2; IC50 = 0.16 μM in a cell-free assay) and a derivative of dorsomorphin . It selectively inhibits VEGFR2 over activin receptor-like kinase 2 (ALK2), ALK5, and AMPK (IC50s = 3.5, >30, and 8 μM, respectively, in a cell-free assay). DMH4 inhibits growth of H460 and A549 human lung cancer cells (GI50s = 13.3 and 2.8 μM, respectively) and reduces VEGF-induced tubule formation in human umbilical vein endothelial cells (HUVECs; IC50 = 1 μM).

Uses

DMH 4 is a selective VEGFR-2 inhibitor. DMH 4 displays antiangiogenic activity in vitro and in vivo.

N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine Preparation Products And Raw materials

Raw materials

Preparation Products

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N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine Suppliers

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515880-75-8, N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazineRelated Search:


  • 4-[2-[4-(3-phenylpyrazolo[1,5-a]pyrimidin-6-yl)phenoxy]ethyl]morpholine
  • N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine
  • DMH-4
  • 6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]-3-phenylpyrazolo[1,5-a]pyriMidine
  • Pyrazolo[1,5-a]pyrimidine, 6-[4-[2-(4-morpholinyl)ethoxy]phenyl]-3-phenyl-
  • DMH4,DMH-4
  • 515880-75-8
  • Aromatics
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals