ChemicalBook > CAS DataBase List > saikogenin A
saikogenin A
- Product Name
- saikogenin A
- CAS No.
- 5092-09-1
- Chemical Name
- saikogenin A
- Synonyms
- Clinopodiside A1;Saikogenin A, 10 mM in DMSO;Oleana-11,13(18)-diene-3,16,23,28-tetrol, (3β,4α,16β)-;Saikogenin A,inhibit,Inhibitor,DPP,1166100,Dipeptidyl Peptidase;(3S,4R,6aR,6bS,8S,8aS,14aR,14bS)-4,8a-Bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,14a,14b-octadecahydropicene-3,8-diol
- CBNumber
- CB21340129
- Molecular Formula
- C30H48O4
- Formula Weight
- 472.7
- MOL File
- 5092-09-1.mol
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saikogenin A Property
- Melting point:
- 287-293 °C
- Boiling point:
- 607.4±55.0 °C(Predicted)
- Density
- 1.16±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 14.47±0.70(Predicted)
- color
- White to off-white
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0034285
- Product name
- SaikogeninA
- Purity
- 98.31%
- Packaging
- 5mg
- Price
- $750
- Updated
- 2021/12/16
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saikogenin A Chemical Properties,Usage,Production
Biological Activity
Saikogenin A, extracted from the traditional Chinese medicine Bupleurum, is a dipeptidyl peptidase IV (DPP-IV) inhibitor.
Biochem/physiol Actions
Saikogenin A is a naturally occurring plant extract that has been shown to have a variety of biological activities. saikogenin A has anti-inflammatory and tumour cell growth inhibiting effects. Its anti-inflammatory effect is due to an increase in corticosterone caused by the release of ACTH and has a direct effect on the inflammatory process. It also inhibits the absorption of ultraviolet light by human skin cells and erythromycin-induced UvB damage.
in vitro
Saikogenin A has certain inhibitory effect on the enzyme DPP-IV. At a concentration of 20 μg/mL DPP-IV inhibition is 47.6%. DPP-IV is a non-classical serine aminopeptidase from its amino terminus of polypeptides and proteins (N-terminus) removing Xaa-Pro dipeptide.
in vivo
Saikogenin A, an anti-inflammatory drug, is present in the crude extract of a Chinese herbal plant called Tsai-Fu. It is less effective in adrenalectomized rats than in normal rats in reducing the carrageenin-induced edema . The anti-inflammatory action of it are due to an increase in corticosterone caused by the release of arenocorticotropic hormone (ACTH) and a direct effect on the process of inflammation.
target
DPP-IV
saikogenin A Preparation Products And Raw materials
Raw materials
Preparation Products
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