LY 223982

Product Name: LY 223982
CAS No.: 117423-74-2
Chemical Name: LY 223982
Synonyms: CGS23131;LY 223982;SKF107324);LY223982,LY-223982;LY223982 Exclusive;SYZSSLLFRVDRHL-QPJJXVBHSA-N;LY223982 (Synonyms: CGS23131;5-(3-Carboxybenzoyl)-2-[(E)-6-(4-methoxyphenyl)-5-hexenyloxy]benzenepropanoic acid;Benzenepropanoic acid, 5-(3-carboxybenzoyl)-2-[[(5E)-6-(4-methoxyphenyl)-5-hexen-1-yl]oxy]-
CBNumber: CB21341434
Molecular Formula: C30H30O7
Formula Weight: 502.55
MOL File: 117423-74-2.mol

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LY 223982 Property

Melting point:: 151-152 °C
Boiling point:: 753.8±60.0 °C(Predicted)
Density: 1.235±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: Chloroform (Slightly, Heated, Sonicated), DMSO (Very Slightly)
form: A crystalline solid
pka: 3.81±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10010024
Product name: LY223982
Purity: ≥98%
Packaging: 1mg
Price: $28
Updated: 2024/03/01

Cayman Chemical

Product number: 10010024
Product name: LY223982
Purity: ≥98%
Packaging: 5mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 10010024
Product name: LY223982
Purity: ≥98%
Packaging: 10mg
Price: $207
Updated: 2024/03/01

Cayman Chemical

Product number: 10010024
Product name: LY223982
Purity: ≥98%
Packaging: 25mg
Price: $448
Updated: 2024/03/01

TRC

Product number: L503108
Product name: LY223982
Packaging: 1mg
Price: $40
Updated: 2021/12/16

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LY 223982 Chemical Properties,Usage,Production

Description

Leukotriene B₄ (LTB₄) is a dihydroxy fatty acid derived from the 5-lipoxygenase pathway of arachidonic acid metabolism and is an important mediator of the inflammatory process. The benzophenone dicarboxylic acid derivative LY223982 is a potent BLT₁ receptor antagonist. It inhibits the specific binding of radiolabeled-LTB₄ to isolated human neutrophils with an IC₅₀ value of 13.2 nM. LY223982 inhibits the leukotriene B₄ (LTB₄)-induced aggregation of guinea pig and human neutrophils with IC₅₀ values of 74 and 100 nM, respectively. However, concentrations of LY223982 up to 10 μM do not inhibit binding of LTB₄ to human BLT₁ or BLT₂ expressed in CHO cells.

Uses

LY223982 is a potent P2Y7 (BLT1) receptor antagonist.

LY 223982 Preparation Products And Raw materials

Raw materials

Preparation Products

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117423-74-2, LY 223982Related Search:

LY 223982 3-(3-FORMYLPHENYL)PROPANOIC ACID METHOXYPHENONE 4-METHOXY-3'-METHYLBENZOPHENONE 3-(2-METHOXYPHENYL)PROPIONIC ACID

LY 223982

5-(3-Carboxybenzoyl)-2-[(E)-6-(4-methoxyphenyl)-5-hexenyloxy]benzenepropanoic acid

SYZSSLLFRVDRHL-QPJJXVBHSA-N

LY223982 Exclusive

LY223982 (Synonyms: CGS23131

SKF107324)

CGS23131

Benzenepropanoic acid, 5-(3-carboxybenzoyl)-2-[[(5E)-6-(4-methoxyphenyl)-5-hexen-1-yl]oxy]-

LY223982,LY-223982

117423-74-2