8-(1,3,4-OXADIAZOL-2-YL)-2,4-BIS(TRIFLUOROMETHYL)IMIDAZO[1,2-A][1,8]NAPHTHYRIDINE
- Product Name
- 8-(1,3,4-OXADIAZOL-2-YL)-2,4-BIS(TRIFLUOROMETHYL)IMIDAZO[1,2-A][1,8]NAPHTHYRIDINE
- CAS No.
- 691868-88-9
- Chemical Name
- 8-(1,3,4-OXADIAZOL-2-YL)-2,4-BIS(TRIFLUOROMETHYL)IMIDAZO[1,2-A][1,8]NAPHTHYRIDINE
- Synonyms
- RO8191;CDM-3008;RO4948191;2-[2,4-Bis(trifluoromethyl)imidazo[1,2-a]1,8-naphthyridin-8-yl]-1,3,4-oxadiazole;8-(1,3,4-OXADIAZOL-2-YL)-2,4-BIS(TRIFLUOROMETHYL)IMIDAZO[1,2-A][1,8]NAPHTHYRIDINE;Imidazo[1,2-a][1,8]naphthyridine, 8-(1,3,4-oxadiazol-2-yl)-2,4-bis(trifluoromethyl)-;HCV,Inhibitor,JAK,Hepatitis C virus,Interferon-alpha/beta receptor,CDM3008,Janus kinase,EMCV,CDM 3008,Tyk2,RO-4948191,RO 4948191,HBV,RO8191,interferon,orally,IFNAR,ISGs,cccDNA,IFNAR1,STAT,inhibit,JAK1,RO-8191,RO 8191,Hepatitis B virus,IFNAR2,imidazonaphthyridine,Interferon-α/β receptor,replicon
- CBNumber
- CB2134747
- Molecular Formula
- C14H5F6N5O
- Formula Weight
- 373.21
- MOL File
- Mol file
8-(1,3,4-OXADIAZOL-2-YL)-2,4-BIS(TRIFLUOROMETHYL)IMIDAZO[1,2-A][1,8]NAPHTHYRIDINE Property
- storage temp.
- Store at 2-8°C
- solubility
- ≤0.1mg/ml in DMSO;0.5mg/ml in dimethyl formamide
- form
- crystalline solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 20449
- Product name
- RO8191
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 20449
- Product name
- RO8191
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 20449
- Product name
- RO8191
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $153
- Updated
- 2024/03/01
- Product number
- 20449
- Product name
- RO8191
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $343
- Updated
- 2024/03/01
- Product number
- C4533
- Product name
- RO8191
- Packaging
- 25mg
- Price
- $435
- Updated
- 2021/12/16
8-(1,3,4-OXADIAZOL-2-YL)-2,4-BIS(TRIFLUOROMETHYL)IMIDAZO[1,2-A][1,8]NAPHTHYRIDINE Chemical Properties,Usage,Production
Biological Activity
ec50: 0.2 μm for anti-hcv activityro8191 is an ifn-α receptor 2 agonist.most acute hepatitis c virus (hcv) infections become chronic and some progress to liver cirrhosis or hepatocellular carcinoma, with thes tandard therapy involving an interferon (ifn)-α-based regimen.
in vitro
previous study found that ro8191had remarkable anti-hcv activity. more importantly, ro8191 exerted its antiviral activity by directly interacting with the type i ifn receptor to drive ifn-stimulated genes (isg) expression, which then induced the antiviral response of innate immune system. previous researchers conducted a systematic structure activity relationship (sar) study on ro8191, and although more than 100 analogues were synthesized, none of the analogues displayed improved anti-hcv activity, suggesting that ro8191 displayed a relative narrow window of sar [1].
in vivo
a previous study evaluated the effects of ro8191 on ifn signaling in mice. results showd that the antiviral genes were significantly induced in the livers of mice treated with ro8191. in addition, genes that had previously been reported to be induced by ifn-b in mouse liver were also induced in the livers of ro8191-treated mice. this study also measured inflammatory cytokine and chemokine expressions, and ro8191 did not significantly induce the expression of these genes. to evaluate the in-vivo anti-hcv activity of ro8191, ro8191 was orally administered to hcv-infected humanized liver mice, and the results showed that ro8191 was able to reduce hcv titer in vivo [2].