carbazomycin B

carbazomycin B Property

storage temp. 

-20°C

solubility 

DMSO: Soluble
Methanol: Soluble

form 

A solid

CAS DataBase Reference

75139-38-7

Hazard and Precautionary Statements (GHS)

carbazomycin B Chemical Properties,Usage,Production

Occurrence

An antibiotic alkaloid isolated from the cultures of an unclassified species of Streptomyces, carbazomycin B has been isolated and characterized as the acetate which forms colourless needles with m.p. 192-195°C.

Uses

Carbazomycin B is a bacterial metabolite and can be isolated from Streptomyces. Carbazomycin B is an antifungal and antibacterial agent. Carbazomycin B inhibits 5-lipoxygenase (5-LO) activity in extract from RBL-1 cell with the IC50 Of 1.5 μM[1]sup>[2]sup>[3]sup>[4].

References

[1] Yamasaki K, Kaneda M, Watanabe K, et al. New antibiotics, carbazomycins A and B. III. Taxonomy and biosynthesis. J Antibiot (Tokyo). 1983;36(5):552-558. DOI:10.7164/antibiotics.36.552
[2] Sakano K, et al. New antibiotics, carbazomycins A and B. I. Fermentation, extraction, purification and physico-chemical and biological properties. J Antibiot (Tokyo). 1980;33(7):683-689. DOI:10.7164/antibiotics.33.683
[3] Naid T, et al. Carbazomycins C, D, E and F, minor components of the carbazomycin complex. J Antibiot (Tokyo). 1987;40(2):157-164. DOI:10.7164/antibiotics.40.157
[4] Hook DJ, et al. Identification of the inhibitory activity of carbazomycins B and C against 5-lipoxygenase, a new activity for these compounds. J Antibiot (Tokyo). 1990 Oct;43(10):1347-8. DOI:10.7164/antibiotics.43.1347
[5] CHAKAPONG INTARAUDOM. Antimalarial and antituberculosis substances from Streptomyces sp. BCC26924[J]. Tetrahedron, 2011, 67 39: Pages 7593-7597. DOI: 10.1016/j.tet.2011.07.053