BI-2493

Product Name: BI-2493
CAS No.: 2937344-16-4
Chemical Name: BI-2493
Synonyms: bi-2493;(S)-2-Amino-3'-(2-((S)-2-methylpiperazin-1-yl)pyrimidin-4-yl)-5',6,6',7-tetrahydro-4'H,5H-spiro[benzo[b]thiophene-4,7'-benzo[d]isoxazole]-3-carbonitrile;(S)-2-Amino-3'-[2-[(S)-2-methyl-1-piperazinyl]-4-pyrimidinyl]-5',6,6',7-tetrahydro-4'H,5H-spiro[benzo[b]thiophene-4,7'-benzo[d]isoxazole]-3-carbonitrile;(S)-2-Amino-3'-(2-((S)-2-methylpiperazin-1-yl)pyrimidin-4-yl)-5',6,6',7-tetrahydro-4'H,5H-spiro[benzo[b]thiophene-4,7'-benzo[d]isoxazole]-3-carbonitrile;Spiro[1,2-benzisoxazole-7(4H),4′(5′H)-benzo[b]thiophene]-3′-carbonitrile, 2′-amino-5,6,6′,7′-tetrahydro-3-[2-[(2S)-2-methyl-1-piperazinyl]-4-pyrimidinyl]-, (4′S)-
CBNumber: CB213613341
Molecular Formula: C24H27N7OS
Formula Weight: 461.58
MOL File: 2937344-16-4.mol

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BI-2493 Property

Boiling point:: 774.2±70.0 °C(Predicted)
Density: 1.41±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
pka: 8.62±0.40(Predicted)
form: Solid
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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BI-2493 Chemical Properties,Usage,Production

Uses

BI-2493 is a structural analog of BI-2865 and a highly selective pan-KRAS inhibitor. This compound can attenuate tumor growth and can also be used for cancer disease research.

in vivo

BI-2493 (90 mg/kg, p.o., twice daily for 21 days) exhibits tumor-suppressive activity in LS513/GP2d/HPAC/SW620/MIAPACA2-derived xenograft NMRI mice models^[1].

Animal Model:	LS513/GP2d/HPAC/SW620/MIAPACA2-derived xenograft NMRI mice models
Dosage:	90 mg/kg
Administration:	Oral gavage (p.o.), twice daily for 21 days
Result:	Reduced tumor growth in mice carrying KRAS G12C, G12D, G12V, and A146V mutation models, without causing significant toxicity to the mice.

IC 50

K-Ras WT

BI-2493 Preparation Products And Raw materials

Raw materials

Preparation Products

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BI-2493 Suppliers

China 30 United States 2 Global 32

Shanghai Tachizaki Biomedical Research Center

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View Lastest Price from BI-2493 manufacturers

Hubei Chuchang Biotech Co., Ltd.

Product: BI-2493 2937344-16-4
Price: US $0.00-0.00/mg
Min. Order: 5mg
Purity: 98%+ HPLC HNMR
Supply Ability: 10g
Release date: 2024-03-29

Shaanxi Dideu New Materials Co. Ltd

Product: BI-2493 2937344-16-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-08

2937344-16-4, BI-2493Related Search:

BI-2852 RMC-9805 RMC-7977 2-Propen-1-one, 1-[(3S)-4-[(7R)-7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]- MRTX1133 BI-2865 BI-3406 Adagrasib

Spiro[1,2-benzisoxazole-7(4H),4′(5′H)-benzo[b]thiophene]-3′-carbonitrile, 2′-amino-5,6,6′,7′-tetrahydro-3-[2-[(2S)-2-methyl-1-piperazinyl]-4-pyrimidinyl]-, (4′S)-

bi-2493

(S)-2-Amino-3'-(2-((S)-2-methylpiperazin-1-yl)pyrimidin-4-yl)-5',6,6',7-tetrahydro-4'H,5H-spiro[benzo[b]thiophene-4,7'-benzo[d]isoxazole]-3-carbonitrile

(S)-2-Amino-3'-[2-[(S)-2-methyl-1-piperazinyl]-4-pyrimidinyl]-5',6,6',7-tetrahydro-4'H,5H-spiro[benzo[b]thiophene-4,7'-benzo[d]isoxazole]-3-carbonitrile

(S)-2-Amino-3'-(2-((S)-2-methylpiperazin-1-yl)pyrimidin-4-yl)-5',6,6',7-tetrahydro-4'H,5H-spiro[benzo[b]thiophene-4,7'-benzo[d]isoxazole]-3-carbonitrile

2937344-16-4