ChemicalBook > CAS DataBase List > hamaudol

hamaudol

Product Name: hamaudol
CAS No.: 735-46-6
Chemical Name: hamaudol
Synonyms: hamaudol;Inhibitor,COX,Hamaudol,Cyclooxygenase,inhibit;(S)-3,5-Dihydroxy-2,2,8-trimethyl-3,4-dihydro-2H,6H-pyrano[3,2-g]chromen-6-one;(S)-3,4-Dihydro-3β,5-dihydroxy-2,2,8-trimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one;2H,6H-Benzo[1,2-b:5,4-b']dipyran-6-one, 3,4-dihydro-3,5-dihydroxy-2,2,8-trimethyl-, (3S)-
CBNumber: CB21363984
Molecular Formula: C15H16O5
Formula Weight: 276.28
MOL File: 735-46-6.mol

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hamaudol Property

Melting point:: 197.0-197.5 °C
Boiling point:: 464.7±45.0 °C(Predicted)
Density: 1.336±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
pka: 6.77±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0100499
Product name: Hamaudol
Packaging: 5mg
Price: $336
Updated: 2021/12/16

ChemScene

Product number: CS-0100499
Product name: Hamaudol
Packaging: 10mg
Price: $571
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb594459
Product name: Hamaudol
Packaging: 20mg
Price: $591.6
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb594459
Product name: Hamaudol
Packaging: 100mg
Price: $1757.8
Updated: 2021/12/16

AK Scientific

Product number: 1210CB
Product name: Hamaudol
Packaging: 500mg
Price: $4775
Updated: 2021/12/16

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hamaudol Chemical Properties,Usage,Production

Uses

Hamaudol is a chromone isolated from Saposhnikovia divaricata. Hamaudol shows significant inhibitory activity on cyclooxygenase (COX)-1 and COX-2 activities with IC50 values of 0.30, 0.57 mM, respectively, and has potent analgesia and anti-inflammary effects[1][2].

Definition

ChEBI: Hamaudol is a member of chromenes.

Biological Activity

Hamaudol is a chromone isolated from Saposhnikovia divaricata. It has obvious inhibitory ability on the activities of cyclooxygenase (COX)-1 and COX-2 with IC50 values of 0.30 and 0.57 mM, respectively, and has potent analgesic and anti-inflammatory effects.

in vivo

Hamaudol (Compound 7) increases the potency to exhibit a potent analgesia at doses of 1, 5 and 10 mg/kg in mice, although it do not show clear dose dependency.

< b>

target

COX-1

< span> 0.3 mM (IC ₅₀ )

COX-2

0.57 mM (IC ₅₀ )

IC 50

COX-1: 0.3 mM (IC₅₀); COX-2: 0.57 mM (IC₅₀)

References

[1] Okuyama E, et al. Analgesic components of saposhnikovia root (Saposhnikovia divaricata). Chem Pharm Bull (Tokyo). 2001 Feb;49(2):154-60. DOI:10.1248/cpb.49.154
[2] Mingshan Zheng, et al. The Constituents Isolated from Peucedanum japonicum Thunb. and their Cyclooxygenase (COX) Inhibitory Activity. Korean Journal of Medicinal Crop Science, 2005, 13(2).

hamaudol Preparation Products And Raw materials

Raw materials

Preparation Products

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735-46-6, hamaudolRelated Search:

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hamaudol

(S)-3,4-Dihydro-3β,5-dihydroxy-2,2,8-trimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one

2H,6H-Benzo[1,2-b:5,4-b']dipyran-6-one, 3,4-dihydro-3,5-dihydroxy-2,2,8-trimethyl-, (3S)-

Inhibitor,COX,Hamaudol,Cyclooxygenase,inhibit

(S)-3,5-Dihydroxy-2,2,8-trimethyl-3,4-dihydro-2H,6H-pyrano[3,2-g]chromen-6-one

735-46-6