phenacid
- Product Name
- phenacid
- CAS No.
- 10477-72-2
- Chemical Name
- phenacid
- Synonyms
- CB-1331;phenacid;NSC-71964;4-(Bis-phenylacetic acid;Phenylacetic acid mustard;Phenylacetic acid Mustard-d8;p-[Bis(2-chloroethyl)amino]phenylacetic acid;4-[Bis(2-chloroethyl)amino]benzeneacetic acid;Benzeneacetic acid, 4-[bis(2-chloroethyl)amino]-;2-[4-[bis(2-chloroethyl)amino]phenyl]acetic acid
- CBNumber
- CB21366556
- Molecular Formula
- C12H15Cl2NO2
- Formula Weight
- 276.16
- MOL File
- 10477-72-2.mol
phenacid Property
- Melting point:
- 105 °C(Solv: benzene (71-43-2); pentane (109-66-0))
- Boiling point:
- 125°C (rough estimate)
- Density
- 1.2884 (rough estimate)
- refractive index
- 1.6070 (estimate)
- pka
- 3.86±0.10(Predicted)
Safety
- HS Code
- 2916340000
- Toxicity
- sln-dmg-par 3 mmol/L GENRA81,173,60
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P319190
- Product name
- PhenylaceticMustard
- Packaging
- 25mg
- Price
- $1470
- Updated
- 2021/12/16
- Product number
- HCH0002607
- Product name
- 2-(4-[DI(2-CHLOROETHYL)AMINO]PHENYL)ACETIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.18
- Updated
- 2021/12/16
phenacid Chemical Properties,Usage,Production
Uses
Phenylacetic Mustard is a nitrogen mustard analog and the active metabolite of Chlorambucil (C325050). It is used as a chemotherapeutic agent and aside from having clastogenic activity, it can also induce chromosome delay.
Safety Profile
Poison by intraperitoneal route. Experimental reproductive effects. Mutation data reported. Whenheated to decomposition it emits toxic fumes of Clí and NOx.
in vivo
Phenylacetic acid mustard (intraperitonealinjection; 0-20 mg/kg; 15 days) shows consistently 1.8-1.9 times greater antitumour potency than CHL, it exhibits an ED15 value of 8.0 mg/kg[2].Phenylacetic acid mustard (intraperitonealinjection; 0-20 mg/kg; single dose) cause 50% lethality at the dose 15.9 mg/kg[2].
| Animal Model: | Inbred male C3H/He mice[1] |
| Dosage: | 0 mg/kg; 5 mg/kg; 10 mg/kg; 20 mg/kg |
| Administration: | Intraperitonealinjection; 15 days |
| Result: | Exhibited anti-tumor activities in vivo. |
phenacid Preparation Products And Raw materials
Raw materials
Preparation Products
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