N(4)-methylcytidine

Product Name: N(4)-methylcytidine
CAS No.: 10578-79-7
Chemical Name: N(4)-methylcytidine
Synonyms: N4-Me-rC;Nsc518744;N4-Methyl-Cr;4-Methylcytidine;Cytidine, N-Methyl-;N(4)-methylcytidine;N4-Methylcytidine, RNA modified nucleoside m4C;1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(methylamino)pyrimidin-2-one
CBNumber: CB21366945
Molecular Formula: C10H15N3O5
Formula Weight: 257.24
MOL File: 10578-79-7.mol

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N(4)-methylcytidine Property

Melting point:: 202-203 °C(Solv: ethanol (64-17-5))
Boiling point:: 504.2±60.0 °C(Predicted)
Density: 1.69±0.1 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Slightly)
pka: 13.48±0.70(Predicted)
form: Solid
color: Off-White to Beige
Stability:: Hygroscopic
InChI: InChI=1S/C10H15N3O5/c1-11-6-2-3-13(10(17)12-6)9-8(16)7(15)5(4-14)18-9/h2-3,5,7-9,14-16H,4H2,1H3,(H,11,12,17)/t5-,7-,8-,9-/m1/s1
InChIKey: LZCNWAXLJWBRJE-ZOQUXTDFSA-N
SMILES: OC[C@H]1O[C@@H](N2C=CC(NC)=NC2=O)[C@H](O)[C@@H]1O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H304May be fatal if swallowed and enters airways

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P331Do NOT induce vomiting.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B426568
Product name: N4-Methylcytidine
Packaging: 5mg
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NM76577
Product name: N4-Methylcytidine
Packaging: 25mg
Price: $140
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NM76577
Product name: N4-Methylcytidine
Packaging: 50mg
Price: $225
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NM76577
Product name: N4-Methylcytidine
Packaging: 100mg
Price: $350
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: NUC0005217
Product name: N4-METHYLCYTIDINE
Purity: 95.00%
Packaging: 100MG
Price: $407.4
Updated: 2021/12/16

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N(4)-methylcytidine Chemical Properties,Usage,Production

Description

N4-Methylcytidine is a nucleoside analogue that inhibits synthesis of human mitochondrial DNA by inhibiting bacterial enzyme uridine-cytidine kinase, which converts uridine to cytidine in the mitochondria. N4-Methylcytidine has been shown to be potent against viruses such as HIV and herpes simplex virus type 1 (HSV-1) in cell culture studies. This antiviral effect is due to the interference with viral dna replication and protein synthesis by preventing incorporation of uracil into dna and ribosomal RNA.

Uses

N4-Methylcytidine (Nsc518744) is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1].

Definition

ChEBI: N4-Methylcytidine is a pyrimidine nucleoside.

References

[1] Gowher H, et al. Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy. Cancer Biol Ther. 2004 Nov;3(11):1062-8. DOI:10.4161/cbt.3.11.1308

N(4)-methylcytidine Preparation Products And Raw materials

Raw materials

Preparation Products

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N(4)-methylcytidine Suppliers

China 59 South Korea 1 Switzerland 1 United Kingdom 1 United States 5 Global 67

Zhengzhou Granlen Sciences, ltd.

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View Lastest Price from N(4)-methylcytidine manufacturers

Career Henan Chemical Co

Product: N(4)-methylcytidine 10578-79-7
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: JD 555
Release date: 2019-09-01

10578-79-7, N(4)-methylcytidineRelated Search:

N(4)-methylcytidine

Nsc518744

Cytidine, N-Methyl-

4-Methylcytidine

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(methylamino)pyrimidin-2-one

N4-Methyl-Cr

N4-Methylcytidine, RNA modified nucleoside m4C

N4-Me-rC

10578-79-7

10587-79-7

10578-79-9