4,5-DEHYDRO DHA Property

solubility 

0.1 M Na2CO3: 1.7 mg/ml; DMF: >100 mg/ml; DMSO: >100 mg/ml; Ethanol: Miscible

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

4,5-DEHYDRO DHA Chemical Properties,Usage,Production

Description

Docosahexaenoic acid (DHA; 22:6ω3) is one of the essential dietary ω-3 unsaturated fatty acids and the preferred n-3 fatty acid for development of the brain and retina.¹ 4,5-dehydro DHA is a novel analog of DHA in which the double bond closest to the carboxyl group has been converted into an acetylene. 4,5-dehydro DHA is a novel compound that has not been studied in biological systems. However, the corresponding acetylene in the C-20 fatty acid series (5,6-dehydro arachidonic acid) is a well known inhibitor of 5-lipoxygenase.²

Definition

ChEBI: 4,5-dehydro Docosahexaenoic Acid is a very long-chain fatty acid.

References

1. Anderson, G.J., Connor, W.E., and Corliss, J.D. Docosahexaenoic acid is the preferred dietary n-3 fatty acid for the development of the brain and retina Pediatr. Res. 27,89-97(1990).
2. Sok, D.E., Han, C.Q., Pai, J.K., et al. Inhibition of leukotriene biosynthesis by acetylenic analogs Biochem. Biophys. Res. Commun. 107,101-108(1982).