5-Methoxybenzofuran-2-carboxylic acid
- Product Name
- 5-Methoxybenzofuran-2-carboxylic acid
- CAS No.
- 10242-08-7
- Chemical Name
- 5-Methoxybenzofuran-2-carboxylic acid
- Synonyms
- AKOS BBS-00007942;TIMTEC-BB SBB010862;ASINEX-REAG BAS 03293533;5-METHOXYBENZOFURAN-2-CARBOXYLIC ACID;5-Methoxy-2-Benzofurancarboxylic Acid;2-Benzofurancarboxylic acid, 5-methoxy-;5-METHOXY-1-BENZOFURAN-2-CARBOXYLIC ACID
- CBNumber
- CB2137319
- Molecular Formula
- C10H8O4
- Formula Weight
- 192.17
- MOL File
- 10242-08-7.mol
5-Methoxybenzofuran-2-carboxylic acid Property
- Melting point:
- 212 °C
- Boiling point:
- 352.4±22.0 °C(Predicted)
- Density
- 1.345±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- solid
- pka
- 3.06±0.30(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C10H8O4/c1-13-7-2-3-8-6(4-7)5-9(14-8)10(11)12/h2-5H,1H3,(H,11,12)
- InChIKey
- XZELWEMGWISCTP-UHFFFAOYSA-N
- SMILES
- O1C2=CC=C(OC)C=C2C=C1C(O)=O
- CAS DataBase Reference
- 10242-08-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-36
- Safety Statements
- 26-36/37/39
- HazardClass
- IRRITANT
- HS Code
- 2932990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- M265708
- Product name
- 5-Methoxybenzofuran-2-carboxylicAcid
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CS-0061982
- Product name
- 5-Methoxy-1-benzofuran-2-carboxylicacid
- Packaging
- 1g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- 2H21-1-04
- Product name
- 5-Methoxybenzofuran-2-carboxylicacid
- Purity
- 98%
- Packaging
- 1g
- Price
- $97
- Updated
- 2021/12/16
- Product number
- OR941323
- Product name
- 5-Methoxybenzofuran-2-carboxylicacid
- Purity
- 95%
- Packaging
- 1g
- Price
- $105
- Updated
- 2021/12/16
- Product number
- 003013
- Product name
- 5-Methoxybenzofuran-2-carboxylic acid
- Purity
- 98%
- Packaging
- 5g
- Price
- $145
- Updated
- 2021/12/16
5-Methoxybenzofuran-2-carboxylic acid Chemical Properties,Usage,Production
Synthesis
50551-56-9
10242-08-7
The general procedure for the synthesis of 5-methoxybenzofuran-2-carboxylic acid from ethyl 5-methoxybenzofuran-2-carboxylate is as follows: 1. 2-Hydroxy-5-methoxybenzaldehyde (3.0 g, 20 mmol) and anhydrous K2CO3 (3.3 g, 23.4 mmol) were dissolved in DMF (50 ml) under the cooling condition in an ice bath, and ethyl bromoacetate (3.3 g, 20 mmol) was added slowly dropwise. After the dropwise addition was completed, the reaction was stirred at 0 °C for 30 min, and then transferred to a 60 °C oil bath and stirred for 12 hours. 2. The reaction solution was poured into ice water and the solid was collected by filtration. The solid was dissolved in chloroform, dried with anhydrous Na2SO4, filtered and purified by silica gel column chromatography, and the solvent was removed by rotary evaporation to give 3.24 g of yellow solid (75% yield). 3. The above product was dissolved in dioxane (30 ml), 1N sodium hydroxide solution (15 ml) was added and stirred at room temperature for 2 hours. The dioxane was removed by evaporation and the residue was poured into ice water, washed sequentially with diethyl ether and dichloromethane and the pH was adjusted to 2. The solid was collected by filtration to give 2.68 g of product (92% yield). 4. The resulting solid was dissolved in methylene dioxane (50 ml), DIC (1.51 g, 11.98 mmol) was added, and after stirring at room temperature for 1 h, DMAP (0.24 g, 1.96 mmol) and dimethyl hydroxyethyl phosphonate (1.84 g, 10.95 mmol) were added. After heating and refluxing for 6 hours, the reaction solution was washed by adding water and saturated brine, dried with anhydrous magnesium sulfate, filtered and evaporated to dryness, and recrystallized by an ethyl acetate-petroleum ether system to give (dimethoxyphosphono)ethyl 5-methoxybenzofuran-2-carboxylate 3.67 g (77% yield). 5. The above ester was dissolved in dichloromethane (50 ml), trimethylmethylsilyl bromide (9.85 g, 64.8 mmol) was added, and stirred at room temperature for 3 hours. After completion of the reaction, the reaction was quenched with methanol and the solvent was removed by evaporation to give a final ethyl phosphine 5-methoxybenzofuran-2-carboxylate 2.38 g (74% yield).
References
[1] Patent: CN103130705, 2016, B. Location in patent: Paragraph 0201-0203
[2] Journal of Medicinal Chemistry, 1984, vol. 27, # 5, p. 570 - 576
[3] Journal of Materials Chemistry, 2001, vol. 11, # 11, p. 2759 - 2772
[4] Patent: US2009/29976, 2009, A1. Location in patent: Page/Page column 18
5-Methoxybenzofuran-2-carboxylic acid Preparation Products And Raw materials
Raw materials
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View Lastest Price from 5-Methoxybenzofuran-2-carboxylic acid manufacturers
- Product
- 5-Methoxybenzofuran-2-carboxylic acid 10242-08-7
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2018-12-23