SM 5887

Product Name: SM 5887
CAS No.: 110311-30-3
Chemical Name: SM 5887
Synonyms: Calsed;SM 5887;AMR hydrochloride;Amrubicin hydrochloride;BHMLHEQFWVQAJS-IERVSNJOSA-N;(1S,3S)-3-Acetyl-3-amino-5,12-dihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-1-tetracenyl2-deoxy-β-D-erythro-pentopyranosidehydrochloride(1:1);(7S,9S)-9-Acetyl-9-amino-7-(2-deoxy-β-D-erythro-pentopyranosyloxy)-6,11-dihydroxy-5,7,8,9,10,12-hexahydro-5,12-naphthacenedione·hydrochloride
CBNumber: CB21374151
Molecular Formula: C25H25NO9.ClH
Formula Weight: 519.931
MOL File: 110311-30-3.mol

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SM 5887 Property

Melting point:: 145-151°

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Safety

Toxicity: LD50 i.v. in mice: 32-50 mg/kg (Morisada)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0004795
Product name: SM 5887
Purity: 95.00%
Packaging: 1MG
Price: $329.7
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0004795
Product name: SM 5887
Purity: 95.00%
Packaging: 5MG
Price: $504.74
Updated: 2021/12/16

Crysdot

Product number: CD31004574
Product name: Amrubicinhydrochloride
Purity: 98+%
Packaging: 5mg
Price: $290
Updated: 2021/12/16

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SM 5887 Chemical Properties,Usage,Production

Description

small and small-cell lung cancers. Amrubicin, a completely synthetic anthracycline derivative, mediates its growth inhibitory action via topoisomerase II inhibition. It is activated in viva by the formation of its 13-OH metabolite, amrubicinol, via reaction with carbonyl reductase. In contrast to doxorubicin and daunorubicin whose metabolites are inactive in the blood, amrubicinol is 10-100 fold more cytotoxic than amrubicin. In phase II clinical trials, amrubicin showed antitumor activity against non-small-cell lung cancers (response rate exceeding 20%) and against untreated extensive stage small-cell-lung cancers (response rate 78.8%). Amrubicin demonstrated a smaller distribution-volume, a shorter half-life in mice and also less chronic cardiotoxicity in preclinical studies compared to doxorubicin. Amrubicin was generally well tolerated with major adverse events being anaemia, leucopenia, thrombocytopenia and neutropenia.

Originator

Sumitomo (Japan)

Uses

Amrubicin (SM-5887) hydrochloride is a DNA topoisomerase II inhibitor, used for the research of cancer.

brand name

Calsed

in vivo

Amrubicin (SM-5887) (25 mg/kg, i.v.) exhibits significant antitumor activities against both SCLC tumors, Lu-24 and Lu-134, with T/C-values (comparing the mean tumor growth rates of the treated group with those of the control group for each day that the tumors are measured) at day 14 of 17% and 9%, respectively. Amrubicin (SM-5887) (25 mg/kg, i.v.) in combination with cisplatin and irinotecan significantly inhibits the growth of tumors compared to amrubicin alone in mice bearing LX-1 tumor cells. Amrubicin (SM-5887) alone or combined with tegafur and uracil also suppresses tumor growth in human cancer xenograft models^[2].

IC 50

Topoisomerase II

References

[1] Hayashi S, et al. Enhancement of radiosensitivity by topoisomerase II inhibitor, amrubicin and amrubicinol, in human lung adenocarcinoma A549 cells and kinetics of apoptosis and necrosis induction. Int J Mol Med. 2006 Nov;18(5):909-15. PMID:17016621
[2] Hanada M, et al. Amrubicin, a novel 9-aminoanthracycline, enhances the antitumor activity of chemotherapeutic agents against human cancer cells in vitro and in vivo. Cancer Sci. 2007 Mar;98(3):447-54. DOI:10.1111/j.1349-7006.2007.00404.x
[3] Hanada M, et al. Amrubicin induces apoptosis in human tumor cells mediated by the activation of caspase-3/7 preceding a loss of mitochondrial membrane potential. Cancer Sci. 2006 Dec;97(12):1396-403. Epub 2006 Sep 21. DOI:10.1111/j.1349-7006.2006.00318.x

SM 5887 Preparation Products And Raw materials

Raw materials

Preparation Products

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SM 5887 Suppliers

Canada 1 China 10 South Korea 1 United States 4 Global 16

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

Shenzhen Botel Biotechnology Co. Ltd.

Tel: 13316949107 13316968096
Email: 1979313431@qq.com
Country: China
ProdList: 9564
Advantage: 58

Beijing xinyanhui pharmaceutical research and development co., LTD

Tel: 13969155946
Email: 1461866103@qq.com
Country: China
ProdList: 16111
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 18438616290
Email: lanwu@univ-bio.com
Country: China
ProdList: 24731
Advantage: 58

Hubei Xinyang Medical Technology Co., Ltd

Tel: 15347293736
Fax: QQ：2853117752
Email: 2853117764@yongstandards.com
Country: China
ProdList: 9996
Advantage: 58

Hubei wei shi reagent group ltd., company

Tel: 027-59102966 18717199209
Fax: 027-59379337
Email: 2853877583@qq.com
Country: China
ProdList: 2715
Advantage: 58

Nantong QuanYi Biotechnology Co., Ltd

Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 5929
Advantage: 58

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View Lastest Price from SM 5887 manufacturers

R&D Scientific Inc.

Product: Amrubicin hydrochloride 110311-30-3
Price: US $4500.00/g
Min. Order: 1g
Purity: 99 %
Supply Ability: 500 Kg
Release date: 2025-04-07

110311-30-3, SM 5887Related Search:

SM 5887

(7S,9S)-9-Acetyl-9-amino-7-(2-deoxy-β-D-erythro-pentopyranosyloxy)-6,11-dihydroxy-5,7,8,9,10,12-hexahydro-5,12-naphthacenedione·hydrochloride

Amrubicin hydrochloride

Calsed

BHMLHEQFWVQAJS-IERVSNJOSA-N

AMR hydrochloride

(1S,3S)-3-Acetyl-3-amino-5,12-dihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-1-tetracenyl2-deoxy-β-D-erythro-pentopyranosidehydrochloride(1:1)

110311-30-3