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ochnaflavone

Product Name
ochnaflavone
CAS No.
50276-96-5
Chemical Name
ochnaflavone
Synonyms
ochnaflavone;Ochinaflavone;Similar to pyriloxanone -7-O- -d - glucopyranoside;2-[4-[5-(5,7-dihydroxy-4-oxochromen-2-yl)-2-hydroxyphenoxy]phenyl]-5,7-dihydroxychromen-4-one;2-[4-[5-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenoxy]phenyl]-5,7-dihydroxy-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 2-[4-[5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenoxy]phenyl]-5,7-dihydroxy-
CBNumber
CB21387317
Molecular Formula
C30H18O10
Formula Weight
538.46
MOL File
50276-96-5.mol
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ochnaflavone Property

Boiling point:
832.1±65.0 °C(Predicted)
Density 
1.622
storage temp. 
2-8°C
pka
6.49±0.40(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
PXT0003631
Product name
OCHNAFLAVONE
Purity
95.00%
Packaging
5MG
Price
$499.11
Updated
2021/12/16
Biorbyt Ltd
Product number
orb105521
Product name
Ochnaflavone
Purity
>98%
Packaging
20mg
Price
$569.5
Updated
2021/12/16
Matrix Scientific
Product number
100419
Product name
Ochnaflavone
Purity
95+%
Packaging
250mg
Price
$742
Updated
2021/12/16
AK Scientific
Product number
6882AB
Product name
Ochnaflavone
Packaging
250mg
Price
$1051
Updated
2021/12/16
Matrix Scientific
Product number
100419
Product name
Ochnaflavone
Purity
95+%
Packaging
1g
Price
$1647
Updated
2021/12/16
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ochnaflavone Chemical Properties,Usage,Production

Uses

Ochnaflavone is an inhibitor of IIA-type secretory phospholipase A2 (sPLA2-IIA) with an IC50 of 3.45 μM. Ochnaflavone exhibits significant anti-inflammatory and liver-protective effects, capable of inhibiting the degradation of phosphatidylethanolamine (PE) and lipid peroxidation induced by carbon tetrachloride (CCl4) in rat liver, with an IC50 of 7.16 μM for lipid peroxidation. Ochnaflavone can be used in research on liver damage and inflammatory diseases[1].

Definition

ChEBI: Ochnaflavone is a biflavonoid with an ether linkage between the B-rings of the apigenin and luteolin subunits. It has been isolated from several members of the Ochnaceae plant family. It has a role as a plant metabolite, an antibacterial agent, a leukotriene antagonist, an anti-inflammatory agent, an EC 3.1.1.4 (phospholipase A2) inhibitor and an antiatherogenic agent. It is a biflavonoid, an aromatic ether and a hydroxyflavone. It is functionally related to a luteolin and an apigenin.

IC 50

sPLA2: 3.45 μM (IC50)

References

[1] Moon TC, et al. Ochnaflavone, naturally occurring biflavonoid, inhibits phospholipase A2 dependent phosphatidylethanolamine degradation in a CCl4-induced rat liver microsome. Biol Pharm Bull. 2006 Dec;29(12):2359-61. DOI:10.1248/bpb.29.2359

ochnaflavone Preparation Products And Raw materials

Raw materials

Preparation Products

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ochnaflavone Suppliers

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50276-96-5, ochnaflavoneRelated Search:

Glabridin

  • ochnaflavone
  • 2-[4-[5-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenoxy]phenyl]-5,7-dihydroxy-4H-1-benzopyran-4-one
  • Ochinaflavone
  • 2-[4-[5-(5,7-dihydroxy-4-oxochromen-2-yl)-2-hydroxyphenoxy]phenyl]-5,7-dihydroxychromen-4-one
  • Similar to pyriloxanone -7-O- -d - glucopyranoside
  • 4H-1-Benzopyran-4-one, 2-[4-[5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenoxy]phenyl]-5,7-dihydroxy-
  • 50276-96-5